c-RET
Los inhibidores de c-RET se dirigen al protooncogén RET (Rearranged during Transfection), que codifica una tirosina quinasa receptora involucrada en el crecimiento, diferenciación y supervivencia celular. La activación anormal de la señalización de RET puede llevar a una proliferación celular descontrolada y resistencia a la apoptosis, contribuyendo al desarrollo de cánceres como el carcinoma medular de tiroides y el cáncer de pulmón de células no pequeñas. Inhibir c-RET puede inducir apoptosis en células cancerosas y es un enfoque prometedor en la terapia contra el cáncer dirigida. En CymitQuimica, ofrecemos una variedad de inhibidores de c-RET de alta calidad para apoyar su investigación en oncología, transducción de señales y apoptosis.
Se han encontrado 51 productos de "c-RET"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Selpercatinib
CAS:<p>"Selpercatinib (LOXO-292) is a RET tyrosine kinase inhibitor with IC50s of 14.0, 24.1, 530.7 nM for different RET mutations."</p>Fórmula:C29H31N7O3Pureza:99.89% - >99.99%Forma y color:SolidPeso molecular:525.6Pyrazoloadenine
CAS:<p>Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) is the inhibitor of human xanthine oxidase.</p>Fórmula:C5H5N5Pureza:99.02%Forma y color:Beige PowderPeso molecular:135.13BBT594
CAS:<p>BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.</p>Fórmula:C28H30F3N7O3Pureza:99.57%Forma y color:SolidPeso molecular:569.58SPP-86
CAS:<p>SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.</p>Fórmula:C16H15N5Pureza:99.53%Forma y color:SolidPeso molecular:277.32RET V804M-IN-1
CAS:<p>RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).</p>Fórmula:C19H16N6OPureza:97.94% - 99.62%Forma y color:SolidPeso molecular:344.37WHI-P180 hydrochloride
CAS:<p>WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor.</p>Fórmula:C16H16ClN3O3Forma y color:SolidPeso molecular:333.77RET-IN-22
CAS:<p>RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-</p>Fórmula:C29H31F3N6O4Forma y color:SolidPeso molecular:584.59RET-IN-15
CAS:<p>RET-IN-15 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.</p>Fórmula:C27H28N8O2Forma y color:SolidPeso molecular:496.56RET-IN-6
CAS:<p>RET-IN-6 is a potent inhibitor of RET (IC50: 4.57 nM).</p>Fórmula:C30H29N7Forma y color:SolidPeso molecular:487.6DUN73423
CAS:<p>DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.</p>Fórmula:C19H16N6OPureza:98.09%Forma y color:SolidPeso molecular:344.37RET-IN-8
CAS:<p>RET-IN-8 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.</p>Fórmula:C27H30N6O3Forma y color:SolidPeso molecular:486.57TRK II-IN-1
CAS:<p>TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.</p>Fórmula:C29H31F3N8OPureza:98%Forma y color:SolidPeso molecular:564.6RET-IN-16
CAS:<p>RET-IN-16: Selective RET inhibitor, IC50s 3.98-15.05 nM for various RET mutations; anticancer properties.</p>Fórmula:C31H29F3N8O2Forma y color:SolidPeso molecular:602.61RET-IN-12
CAS:<p>RET-IN-12 is a RET inhibitor capable of acting on RET(WT) (IC50: 0.3 nM) and RET(V804M) (IC50: 1 nM).</p>Fórmula:C30H30F3N5O4Forma y color:SolidPeso molecular:581.59RET-IN-23
CAS:<p>RET-IN-23 is an orally available and highly potent RET inhibitor with significant antitumor activity for the study of non-small cell lung cancer.</p>Fórmula:C28H28FN11Pureza:97.46%Forma y color:SolidPeso molecular:537.59RET-IN-3
CAS:<p>RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.</p>Fórmula:C18H21N5O2Pureza:99.52%Forma y color:SolidPeso molecular:339.39RET-IN-25
CAS:<p>RET-IN-25 (compound 6b) is an anticancer RET kinase inhibitor that demonstrates efficacy against medullary thyroid carcinoma (MTC), exhibiting half-maximal</p>Fórmula:C22H17N3O5SForma y color:SolidPeso molecular:435.45RET-IN-17
CAS:<p>RET-IN-17 inhibits RET kinase; may help in IBS pain and RET-activated cancers.</p>Fórmula:C27H28F4N4O4Forma y color:SolidPeso molecular:548.53Vepafestinib
CAS:<p>Vepafestinib is a RET inhibitor with potential antineoplastic activity[1].</p>Fórmula:C26H30N6O3Pureza:98.56%Forma y color:SolidPeso molecular:474.55RET-IN-24
CAS:<p>RET-IN-24 (Compound 26) is a selective inhibitor of RET tyrosine kinase, demonstrating antitumor activity [1].</p>Fórmula:C27H26F2N8OForma y color:SolidPeso molecular:516.55
