c-RET
Los inhibidores de c-RET se dirigen al protooncogén RET (Rearranged during Transfection), que codifica una tirosina quinasa receptora involucrada en el crecimiento, diferenciación y supervivencia celular. La activación anormal de la señalización de RET puede llevar a una proliferación celular descontrolada y resistencia a la apoptosis, contribuyendo al desarrollo de cánceres como el carcinoma medular de tiroides y el cáncer de pulmón de células no pequeñas. Inhibir c-RET puede inducir apoptosis en células cancerosas y es un enfoque prometedor en la terapia contra el cáncer dirigida. En CymitQuimica, ofrecemos una variedad de inhibidores de c-RET de alta calidad para apoyar su investigación en oncología, transducción de señales y apoptosis.
Se han encontrado 61 productos de "c-RET"
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BBT594
CAS:BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.Fórmula:C28H30F3N7O3Pureza:99.57%Forma y color:SolidPeso molecular:569.58RET V804M-IN-1
CAS:RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).Fórmula:C19H16N6OPureza:97.94% - 99.62%Forma y color:SolidPeso molecular:344.37Ref: TM-T8467
1mg35,00€2mg50,00€5mg74,00€10mg90,00€25mg157,00€50mg236,00€100mg334,00€200mg495,00€1mL*10mM (DMSO)82,00€TPX-0046
CAS:TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.
Fórmula:C21H21FN6O3Pureza:99.95%Forma y color:SolidPeso molecular:424.43Selpercatinib
CAS:"Selpercatinib (LOXO-292) is a RET tyrosine kinase inhibitor with IC50s of 14.0, 24.1, 530.7 nM for different RET mutations."Fórmula:C29H31N7O3Pureza:99.89% - >99.99%Forma y color:SolidPeso molecular:525.6Ref: TM-T8222
2mg34,00€5mg49,00€10mg84,00€25mg166,00€50mg259,00€100mg477,00€200mg692,00€500mg1.035,00€1mL*10mM (DMSO)56,00€Pyrazoloadenine
CAS:Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) is the inhibitor of human xanthine oxidase.Fórmula:C5H5N5Pureza:99.02%Forma y color:Beige PowderPeso molecular:135.13GSK3179106
CAS:GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nMFórmula:C22H21F4N3O4Pureza:99.8% - 99.90%Forma y color:SolidPeso molecular:467.41Treprostinil Sodium
CAS:Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).Fórmula:C23H33NaO5Pureza:99.67% - >99.99%Forma y color:SolidPeso molecular:412.5SPP-86
CAS:SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.Fórmula:C16H15N5Pureza:99.53%Forma y color:SolidPeso molecular:277.32Ref: TM-T16923
1mg46,00€5mg90,00€10mg144,00€25mg281,00€50mg447,00€100mg650,00€500mg1.369,00€1mL*10mM (DMSO)90,00€WHI-P180 hydrochloride
CAS:WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor.Fórmula:C16H16ClN3O3Forma y color:SolidPeso molecular:333.77AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Fórmula:C22H19F4N7OPureza:99.49% - 99.75%Forma y color:SolidPeso molecular:473.43Ref: TM-T4301
1mg44,00€5mg96,00€10mg138,00€25mg268,00€50mg439,00€100mg645,00€500mg1.333,00€1mL*10mM (DMSO)90,00€RET-IN-16
CAS:RET-IN-16: Selective RET inhibitor, IC50s 3.98-15.05 nM for various RET mutations; anticancer properties.Fórmula:C31H29F3N8O2Forma y color:SolidPeso molecular:602.61RET-IN-15
CAS:RET-IN-15 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.Fórmula:C27H28N8O2Forma y color:SolidPeso molecular:496.56RET-IN-8
CAS:RET-IN-8 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.Fórmula:C27H30N6O3Forma y color:SolidPeso molecular:486.57RET-IN-12
CAS:RET-IN-12 is a RET inhibitor capable of acting on RET(WT) (IC50: 0.3 nM) and RET(V804M) (IC50: 1 nM).Fórmula:C30H30F3N5O4Forma y color:SolidPeso molecular:581.59RET-IN-6
CAS:RET-IN-6 is a potent inhibitor of RET (IC50: 4.57 nM).Fórmula:C30H29N7Forma y color:SolidPeso molecular:487.6RET-IN-22
CAS:RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-Fórmula:C29H31F3N6O4Forma y color:SolidPeso molecular:584.59XMD15-44
CAS:XMD15-44, a RET kinase inhibitor, demonstrates potent growth-inhibitory effects on RAT1 cells transformed by RET/C634R and RET/M918T, with IC50 values of 11.5 nM and 8.3 nM, respectively. It effectively inhibits RET kinase activity and signaling in human thyroid cancer cell lines harboring oncogenic RET alleles, thereby reducing cell proliferation.Fórmula:C29H29F3N4OForma y color:SolidPeso molecular:506.56DUN73423
CAS:DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.Fórmula:C19H16N6OPureza:98.09%Forma y color:SolidPeso molecular:344.37TRK II-IN-1
CAS:TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.Fórmula:C29H31F3N8OPureza:98%Forma y color:SolidPeso molecular:564.6RET-IN-3
CAS:RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.Fórmula:C18H21N5O2Pureza:99.52%Forma y color:SolidPeso molecular:339.39Ref: TM-T9673
1mg70,00€5mg149,00€10mg227,00€25mg427,00€50mg675,00€100mg1.035,00€200mg1.395,00€1mL*10mM (DMSO)165,00€
