IGF-1R
Los inhibidores de IGF-1R son compuestos que se dirigen específicamente al receptor de factor de crecimiento similar a la insulina tipo 1 (IGF-1R), una tirosina quinasa receptora involucrada en el crecimiento, desarrollo y supervivencia celular. La señalización de IGF-1R juega un papel significativo en la progresión del cáncer, lo que hace que estos inhibidores sean valiosos en la investigación oncológica. En CymitQuimica, ofrecemos inhibidores de IGF-1R para apoyar su investigación en biología del cáncer, endocrinología y desarrollo de terapias dirigidas.
Se han encontrado 104 productos de "IGF-1R"
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Ganitumab
CAS:Ganitumab (AMG 479) is a potent monoclonal antibody targeting IGF1R with 0.22 nM affinity; used in cancer research.Pureza:100% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:145.70 kDaRobatumumab
CAS:Robatumumab (Sch 717454) is a fully humanized anti-IGF-1R monoclonal antibody with antitumor activity and antiproliferative activity.Pureza:96.9% (SDS-PAGE); 98.1% (SEC-HPLC) - 96.9% (SDS-PAGE); 98.1% (SEC-HPLC)Forma y color:LiquidMSDC-0602K
CAS:MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.Fórmula:C19H16KNO5SPureza:99.42%Forma y color:SolidPeso molecular:409.5AZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Fórmula:C27H32ClN7O2Pureza:99.65%Forma y color:SolidPeso molecular:522.04ALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Fórmula:C23H28BrN7O3SPureza:98.27%Forma y color:SolidPeso molecular:562.48Ref: TM-T10285
1mg52,00€5mg116,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)143,00€GIP (human) acetate
GIP (human) acetate boosts insulin, limits gastric acid, affects lipid metabolism, and obesity development.Pureza:98.65%Forma y color:SoildGIP (3-42), human
CAS:Human GIP (3-42) is a peptide antagonist of GIP receptors, affecting insulin regulation and diabetes research.Fórmula:C214H324N58O63SPureza:95.73%Forma y color:SolidPeso molecular:4749.35Insulin α-chain (1-13)
CAS:<p>Insulin alpha-chain peptide, amino acids 1-13, T cell-recognized, posttranslationally modified.</p>Fórmula:C66H118N20O22S3Pureza:98%Forma y color:SolidPeso molecular:1639.96IGF-I (24-41)
CAS:<p>IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.</p>Fórmula:C88H133N27O28Pureza:98%Forma y color:SolidPeso molecular:2017.16Xenin 8 acetate
Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family.Fórmula:C53H83N15O11Pureza:95.54%Forma y color:SoildPeso molecular:1106.32cis-NVP-ADW742
CAS:NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Fórmula:C28H31N5OForma y color:SolidPeso molecular:453.59Proinsulin C-Peptide (55-89), human
CAS:Proinsulin, insulin's precursor, has A and B chains linked by a 31 amino acid C-peptide. Enzymes cleave it, yielding insulin and C-peptide.Fórmula:C153H259N49O52Pureza:98%Forma y color:SolidPeso molecular:3616.99GIP (3-42), human acetate
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolismPureza:98%Forma y color:LiquidHNMPA
CAS:<p>HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.</p>Fórmula:C11H11O4PPureza:99.18%Forma y color:SolidPeso molecular:238.18Ref: TM-T21761
1mg50,00€2mg65,00€5mg93,00€10mg144,00€25mg301,00€50mg452,00€100mg660,00€500mg1.396,00€INSR agonist 1
INSR agonist 1, an insulin receptor (INSR) agonist, effectively elevates INSR pY1355/1361 levels and exhibits synergistic effects with insulin.Fórmula:C36H47BrN4O6Forma y color:SolidPeso molecular:711.69GIP, human
CAS:<p>Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.</p>Fórmula:C226H338N60O66SPureza:98%Forma y color:SolidPeso molecular:4983.6[Pro3]-GIP (Mouse)
GIP receptor blocker, 2.6μM IC50, hinders insulin release, regulates glucose in ob/ob mice, and enhances glucose tolerance.Fórmula:C225H342N62O64SPureza:98%Forma y color:SolidPeso molecular:4971.62AVE1642
AVE1642 is a human IgG monoclonal antibody (mAb) that specifically targets CD221/IGF1R. It has the ability to slow the growth of tumor xenografts and extend the survival of tumor-bearing nude mice. AVE1642 is applicable in the study of advanced solid tumors. Recommended isotype control: HumanIgG1kappa, Isotype Control.Forma y color:Odour LiquidOI338
OI338 is an orally available, ultralong-acting insulin analogue.Fórmula:C260H403N65O84S6Forma y color:SolidPeso molecular:5971.76[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
CAS:Insulin Receptor (1142-1153) binds insulin, is a substrate for its kinase, and has research/medical potential.Fórmula:C72H110N19O33P3Pureza:98%Forma y color:SolidPeso molecular:1862.67CPF-7
CAS:CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulationFórmula:C118H193N33O32Forma y color:SolidPeso molecular:2586LDD39
LDD39, a PROTAC targeting the degradation of RET protein, effectively and persistently degrades total RET (tRET) protein in vivo and inhibits phosphorylated RET (pRET) signaling.Fórmula:C55H59F2N11O6Forma y color:SolidPeso molecular:1008.12C-Peptide 2, rat
CAS:C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion.Fórmula:C135H222N38O49Forma y color:SolidPeso molecular:3161.478TAK-778
CAS:TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.Fórmula:C24H28NO7PSPureza:98%Forma y color:SolidPeso molecular:505.52IGF-I (30-41)
CAS:IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).Fórmula:C51H83N19O19Pureza:98%Forma y color:SolidPeso molecular:1266.34TLK19781
CAS:TLK19781 is an insulin receptor modulator.Fórmula:C33H24Cl2N4O13S4Pureza:98%Forma y color:SolidPeso molecular:883.73Proinsulin C-peptide (human)
CAS:C-peptide, a 31-amino acid, links Proinsulin A & B chains for correct folding and function.Fórmula:C129H211N35O48Pureza:98%Forma y color:SolidPeso molecular:3020.26Gastric Inhibitory Peptide (1-42) (porcine) TFA
<p>Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.</p>Fórmula:C225H342N60O66S·XCF3COOHForma y color:SolidPeso molecular:4975.55GIP (1-39)
CAS:Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.Fórmula:C210H316N56O61SPureza:98%Forma y color:SolidPeso molecular:4633.21Teprotumumab
CAS:<p>Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.</p>Pureza:SDS-PAGE:95.2%;SEC-HPLC:99.6%Forma y color:LiquidPeso molecular:145.62 kDaCixutumumab
CAS:Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impedingPureza:98.5% (SDS-PAGE); 97.5% (SEC-HPLC) - 98.5% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:LiquidInsulin efsitora alfa
CAS:Insulin efsitora alfa(LY-3209590) is an IR agonist and a fusion protein that binds a novel single-chain insulin variant to the structural domain of human IgG FcPureza:98.3% (SDS-PAGE); 98.1% (SEC-HPLC) - 98.3% (SDS-PAGE); 98.1% (SEC-HPLC)Forma y color:LiquidPeso molecular:32.04 kDaInsulin glulisine
CAS:Insulin glulisine (HMR 1964), a rapid-acting analogue, mimics human insulin; used in diabetes research.Fórmula:C258H384N64O78S6Forma y color:SolidPeso molecular:5822.57[D-Ala2]-GIP (human)
CAS:Potent GIP receptor agonist with 630 pM EC50; enhances cAMP, glucose control, insulin, cognition in diabetic/obese animals; neuroprotective in PD model.Fórmula:C226H338N60O66SPureza:98%Forma y color:SolidPeso molecular:4983.58Xenin-8
CAS:neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effectsFórmula:C51H79N15O9Pureza:98%Forma y color:SolidPeso molecular:1046.27IGF-1R inhibitor-2
CAS:IGF-1R inhibitor-2 blocks the insulin-like growth factor-1 receptor, potentially reversing tumor cell transformation and increasing apoptosis susceptibility.Fórmula:C24H24FN7O2Forma y color:SolidPeso molecular:461.501GIP (1-30) amide,human
CAS:GIP (1-30) amide (Human) is a glucose-dependent insulinotropic polypeptide that stimulates insulin secretion, reducing postprandial glycemic issues.Fórmula:C162H240N40O47SPureza:98%Forma y color:SolidPeso molecular:3531.94Valanafusp alfa
CAS:Valanafusp alfa (AGT-181) is a fusion protein targeting HIR and IDUA for MPS I research.Forma y color:LiquidWAY-270250
CAS:WAY-270250 is an IGF-1R/SRC inhibitor.Fórmula:C18H16N2O2Pureza:99.97%Forma y color:SoildPeso molecular:292.33PQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Fórmula:C18H16ClN3O2Pureza:99.77%Forma y color:SolidPeso molecular:341.79Insulin sensitizer C59
CAS:Insulin sensitizer C59 is an orally available insulin sensitizer that improves glucose uptake and can be used to study insulin-stimulated GLUT4 translocation.Fórmula:C16H18Cl2N2OPureza:99.98%Forma y color:SoildPeso molecular:325.23ZIGIR
ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.Fórmula:C39H40N6O3Pureza:98.34% - 99.32%Forma y color:SolidPeso molecular:640.77Acetyl Gastric Inhibitory Peptide (human)
CAS:Acetyl Gastric Inhibitory Peptide: improved insulinotropic, antihyperglycemic, for diabetes/obesity research.Fórmula:C228H340N60O67SForma y color:SolidPeso molecular:5025.6Insulin peglispro
CAS:Insulin peglispro (BIL) is a basal insulin with a stable, extended activity and may offer improved blood sugar control.Fórmula:C370H566N104O110S4Forma y color:SolidPeso molecular:8359.32(Pro3) GIP, human
CAS:(Pro3) GIP, human: stable hGIPR full agonist, high affinity (Ki/Kd=0.90nM), for obesity-related diabetes research.Fórmula:C226H338N60O64SForma y color:SolidPeso molecular:4951.53DA-JC4
CAS:DA-JC4: dual GLP-1/GIP agonist, for neurological disease research and insulin pathway studies.Fórmula:C225H346N56O65Forma y color:SolidPeso molecular:4875.49Macupatide
CAS:Macupatide is a gastric inhibitory polypeptide (GIP) receptor agonist, utilized in research related to antidiabetic applications.Forma y color:SolidGIP (1-30) amide, porcine TFA
GIP (1-30) amide, porcine TFA: a full GIP receptor agonist, similar to natural GIP(1-42), stimulates insulin, mildly inhibits gastric acid.Forma y color:LiquidNBI-31772
CAS:<p>NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).</p>Fórmula:C17H11NO7Pureza:99.79%Forma y color:SolidPeso molecular:341.27IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisForma y color:Lyophilized PowderPeso molecular:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.IGF1R/CD221 Protein, Mouse, Recombinant (His)
IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:> 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLCForma y color:Lyophilized PowderPeso molecular:80.72+23.0 kDa (predicted); 110-140 kDa and 50-65 kDa, corresponding to the α subunit and β subunit respectively (reducing condition, due to glycosylation)Ref: TM-TMPY-06195
1mg4.479,00€5µg95,00€10µg136,00€20µg215,00€50µg428,00€100µg709,00€200µg1.235,00€500µg2.539,00€IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisForma y color:Lyophilized PowderPeso molecular:80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.HNMPA-(AM)3
CAS:HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。 此外，HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM，在蚊子和哺乳动物中分别) 具有抑制作用。Fórmula:C20H23O10PPureza:97.22%Forma y color:SolidPeso molecular:454.36IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisForma y color:Lyophilized PowderPeso molecular:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result.Ref: TM-TMPK-00456
5µg97,00€10µg157,00€20µg252,00€50µg497,00€100µg823,00€200µg1.488,00€500µg3.185,00€IMP2-IN-1
CAS:IMP2-IN-1 effectively inhibits IMP2 (IC50: 81.3-127.5 μM), reduces IMP2 in SW480 cells, and hinders Huh7 cell activity.Fórmula:C21H14F3NO4Forma y color:SolidPeso molecular:401.34XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Fórmula:C22H31N9OPureza:99.07%Forma y color:SolidPeso molecular:437.54Ref: TM-T17267
1mg56,00€2mg78,00€5mg99,00€10mg149,00€25mg258,00€50mg393,00€100mg582,00€1mL*10mM (DMSO)110,00€NVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Fórmula:C23H25ClN6O3Pureza:98.07% - 98.78%Forma y color:SolidPeso molecular:468.94Ref: TM-T1918
1mg48,00€2mg63,00€5mg101,00€10mg163,00€25mg264,00€50mg378,00€100mg567,00€1mL*10mM (DMSO)101,00€GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Fórmula:C27H29FN8O3Pureza:98.89% - >99.99%Forma y color:SolidPeso molecular:532.57NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFórmula:C27H29N5OPureza:98.7% - 99.86%Forma y color:SolidPeso molecular:439.55NVP-ADW742
CAS:NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-AblFórmula:C28H31N5OPureza:96.14% - 98.70%Forma y color:SolidPeso molecular:453.58NT157
CAS:NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Fórmula:C16H14BrNO5SPureza:99.64%Forma y color:SolidPeso molecular:412.26Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Fórmula:C42H70O12Pureza:98% - 99.65%Forma y color:SolidPeso molecular:767.00Ref: TM-T6S1487
1mg113,00€5mg265,00€10mg426,00€25mg702,00€50mg938,00€100mg1.320,00€1mL*10mM (DMSO)360,00€Insulin(cattle)
CAS:<p>Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.</p>Fórmula:C254H377N65O75S6Pureza:98%Forma y color:SolidPeso molecular:5733.49NBI-31772 hydrate
NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.Fórmula:C17H13NO8Forma y color:SolidPeso molecular:372.82Linsitinib
CAS:<p>OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.</p>Fórmula:C26H23N5OPureza:99.71% - ≥95%Forma y color:SolidPeso molecular:421.49AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Fórmula:C24H25ClN6OPureza:99.13%Forma y color:SolidPeso molecular:448.95AG1024
CAS:AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).Fórmula:C14H13BrN2OPureza:98% - 99.37%Forma y color:SolidPeso molecular:305.17MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Fórmula:C12H11N3O4SPureza:99.39%Forma y color:SolidPeso molecular:293.3Ref: TM-T8773
1mg50,00€5mg97,00€10mg145,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)109,00€BRD7552
CAS:BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.Fórmula:C33H33N3O15Pureza:>99.99% - ≥98%Forma y color:SolidPeso molecular:711.63Sari 59-801
CAS:Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release.Fórmula:C18H23N3O2Pureza:99.92%Forma y color:SolidPeso molecular:313.39Ref: TM-T34532
1mg37,00€5mg113,00€10mg170,00€25mg278,00€50mg386,00€100mg520,00€1mL*10mM (DMSO)114,00€Glymidine
CAS:Glycodiazine, a sulfadiazine derivative, reduces blood sugar by boosting insulin release and sensitivity.Fórmula:C13H15N3O4SForma y color:SolidPeso molecular:309.34GIP (1-30) amide, porcine acetate
GIP (1-30) amide, porcine is a GIP receptor agonist that stimulates insulin and mildly inhibits gastric acid.Fórmula:C164H249N41O49SPureza:98.50%Forma y color:SolidPeso molecular:3611.04Glymidine sodium
CAS:Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion.Fórmula:C13H14N3NaO4SPureza:98.19%Forma y color:SolidPeso molecular:331.32PQ401 hydrochloride (196868-63-0(free base))
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.Fórmula:C18H17Cl2N3O2Pureza:99.86%Forma y color:SolidPeso molecular:378.25Insulin (human)
CAS:Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood.Fórmula:C257H383N65O77S6Pureza:97.32% - 99.99%Forma y color:SolidPeso molecular:5807.57MSDC 0160
CAS:MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.Fórmula:C19H18N2O4SPureza:98.11% - 99.53%Forma y color:SolidPeso molecular:370.42Ref: TM-T2607
1mg35,00€2mg50,00€5mg77,00€10mg99,00€25mg154,00€50mg197,00€100mg350,00€1mL*10mM (DMSO)82,00€MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Fórmula:C21H18N2OPureza:98.53%Forma y color:SolidPeso molecular:314.38AZ7550
CAS:AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Fórmula:C27H31N7O2Pureza:97.07% - 99.75%Forma y color:SolidPeso molecular:485.58Ceritinib dihydrochloride
CAS:<p>Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.</p>Fórmula:C28H38Cl3N5O3SPureza:99.85% - 99.99%Forma y color:SolidPeso molecular:631.06Ceritinib
CAS:Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C28H36ClN5O3SPureza:98.52% - 99.77%Forma y color:SolidPeso molecular:558.14Picropodophyllin
CAS:Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.Fórmula:C22H22O8Pureza:98.38% - 99.83%Forma y color:SolidPeso molecular:414.41Ref: TM-T6943
5mg64,00€10mg88,00€25mg170,00€50mg316,00€100mg535,00€500mg1.121,00€1mL*10mM (DMSO)69,00€BMS-536924
CAS:BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity forFórmula:C25H26ClN5O3Pureza:99.02%Forma y color:SolidPeso molecular:479.96Indirubin Derivative E804
CAS:Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.Fórmula:C20H19N3O4Pureza:98.54%Forma y color:SolidPeso molecular:365.38Ref: TM-T11654
1mg44,00€5mg93,00€10mg131,00€25mg207,00€50mg309,00€100mg459,00€200mg657,00€1mL*10mM (DMSO)87,00€GSK1904529A
CAS:GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .Fórmula:C44H47F2N9O5SPureza:98.2% - 99.76%Forma y color:SolidPeso molecular:851.96Figitumumab
CAS:Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.Pureza:95%Forma y color:LiquidAnti-IGFBP2 Antibody (M14)
Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.Forma y color:Odour LiquidDusigitumab
CAS:<p>Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.</p>Pureza:95% - 95%Forma y color:LiquidVeligrotug
CAS:Veligrotug is an IV anti-IGF-1R antibody for thyroid eye disease, reducing diplopia and orbital inflammation, supporting autoimmune ophthalmopathy research.Pureza:95% - 96.7% (SDS-PAGE); 99.8% (SEC-HPLC)Forma y color:LiquidS961
CAS:S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.Fórmula:C211H297N55O71S2Pureza:98%Forma y color:SolidPeso molecular:4804.13BMS-754807
CAS:BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Fórmula:C23H24FN9OPureza:99.69% - 99.94%Forma y color:SolidPeso molecular:461.49Ref: TM-T2349
1mg49,00€2mg70,00€5mg96,00€10mg166,00€25mg328,00€50mg537,00€100mg772,00€1mL*10mM (DMSO)116,00€AZ12253801
CAS:AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.Fórmula:C21H22N8OPureza:98%Forma y color:SolidPeso molecular:402.45BM-131246
CAS:BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.Fórmula:C22H20N2O4SPureza:>99.99%Forma y color:SolidPeso molecular:408.47KU14R
CAS:KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.Fórmula:C13H14N2OPureza:98%Forma y color:White SolidPeso molecular:214.26IMP2-IN-2
CAS:IMP2-IN-2: potent, selective IMP2 inhibitor; IC50s: 120.9 μM (RNA_A), 236.7 μM (RNA_B); used in cancer research.Fórmula:C22H19F3N2O3SForma y color:SolidPeso molecular:448.46H-1356
CAS:H-1356 is an insulin-like growth factor 1(IGF-I) analog that inhibits autophosphorylation of IGF-I receptor.Fórmula:C55H88N14O15S2Forma y color:SolidPeso molecular:1249.5D-(+)-Sorbose
CAS:D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.Fórmula:C6H12O6Forma y color:SolidPeso molecular:180.16Protonstatin-1
CAS:Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.Fórmula:C8H5NO2S2Pureza:99.77%Forma y color:SolidPeso molecular:211.26Ref: TM-T71812
1mg96,00€5mg227,00€10mg329,00€25mg567,00€50mg753,00€100mg1.035,00€200mg1.406,00€1mL*10mM (DMSO)250,00€NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Fórmula:C16H14BrNO5SPureza:98.06% - 99.72%Forma y color:SolidPeso molecular:412.26I-OMe-Tyrphostin AG 538
CAS:I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.Fórmula:C17H12INO5Pureza:98.8%Forma y color:SolidPeso molecular:437.19Ref: TM-T11593
1mg56,00€5mg119,00€10mg187,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)131,00€BMS-695735
CAS:BMS-695735: benzimidazole, inhibits IGF-1 receptor, broad antitumor effects, affects CYP3A4, low solubility, binds plasma proteins.Fórmula:C26H31ClFN7OForma y color:SolidPeso molecular:512.02NBI-6024
CAS:NBI-6024, an altered peptide ligand (APL), serves as an epitope for interferon-gamma-producing T helper lymphocytes associated with inflammation in patientsFórmula:C66H112N20O21Forma y color:SolidPeso molecular:1521.72Tyrphostin AG 538
CAS:Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.Fórmula:C16H11NO5Pureza:98.75%Forma y color:SoildPeso molecular:297.26IGF-1R inhibitor-4
CAS:IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.Fórmula:C13H15ClN4OForma y color:SolidPeso molecular:278.737AGL-2263
CAS:AGL-2263 is a blocker of insulin receptor (IR)Fórmula:C17H10N2O5Forma y color:SolidPeso molecular:322.27
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