IGF-1R
Los inhibidores de IGF-1R son compuestos que se dirigen específicamente al receptor de factor de crecimiento similar a la insulina tipo 1 (IGF-1R), una tirosina quinasa receptora involucrada en el crecimiento, desarrollo y supervivencia celular. La señalización de IGF-1R juega un papel significativo en la progresión del cáncer, lo que hace que estos inhibidores sean valiosos en la investigación oncológica. En CymitQuimica, ofrecemos inhibidores de IGF-1R para apoyar su investigación en biología del cáncer, endocrinología y desarrollo de terapias dirigidas.
Se han encontrado 86 productos de "IGF-1R"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ALK inhibitor 1
CAS:<p>ALK inhibitor 1 is a selective ALK kinase inhibitor.</p>Fórmula:C23H28BrN7O3SPureza:98.27%Forma y color:SolidPeso molecular:562.48AZ7550 hydrochloride
CAS:<p>AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Fórmula:C27H32ClN7O2Pureza:99.65%Forma y color:SolidPeso molecular:522.04GIP (3-42), human
CAS:<p>Human GIP (3-42) is a peptide antagonist of GIP receptors, affecting insulin regulation and diabetes research.</p>Fórmula:C214H324N58O63SPureza:95.73%Forma y color:SolidPeso molecular:4749.35GIP (human) acetate
<p>GIP (human) acetate boosts insulin, limits gastric acid, affects lipid metabolism, and obesity development.</p>Pureza:98.65%Forma y color:SoildRobatumumab
CAS:<p>Robatumumab (Sch 717454) is a fully humanized anti-IGF-1R monoclonal antibody with antitumor activity and antiproliferative activity.</p>Pureza:96.9% (SDS-PAGE); 98.1% (SEC-HPLC) - 96.9% (SDS-PAGE); 98.1% (SEC-HPLC)Forma y color:LiquidGanitumab
CAS:<p>Ganitumab (AMG 479) is a potent monoclonal antibody targeting IGF1R with 0.22 nM affinity; used in cancer research.</p>Pureza:100% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:145.70 kDaMSDC-0602K
CAS:<p>MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.</p>Fórmula:C19H16KNO5SPureza:99.42%Forma y color:SolidPeso molecular:409.5[Pro3]-GIP (Mouse)
<p>GIP receptor blocker, 2.6μM IC50, hinders insulin release, regulates glucose in ob/ob mice, and enhances glucose tolerance.</p>Fórmula:C225H342N62O64SPureza:98%Forma y color:SolidPeso molecular:4971.62Gastric Inhibitory Peptide (1-42) (porcine) TFA
<p>Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.</p>Fórmula:C225H342N60O66S·XCF3COOHForma y color:SolidPeso molecular:4975.55IGF-I (24-41)
CAS:<p>IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.</p>Fórmula:C88H133N27O28Pureza:98%Forma y color:SolidPeso molecular:2017.16cis-NVP-ADW742
CAS:<p>NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.</p>Fórmula:C28H31N5OForma y color:SolidPeso molecular:453.59GIP, human
CAS:<p>Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.</p>Fórmula:C226H338N60O66SPureza:98%Forma y color:SolidPeso molecular:4983.6AVE1642
<p>AVE1642 is a human IgG monoclonal antibody (mAb) that specifically targets CD221/IGF1R. It has the ability to slow the growth of tumor xenografts and extend the survival of tumor-bearing nude mice. AVE1642 is applicable in the study of advanced solid tumors. Recommended isotype control: HumanIgG1kappa, Isotype Control.</p>Forma y color:Odour LiquidOI338
<p>OI338 is an orally available, ultralong-acting insulin analogue.</p>Fórmula:C260H403N65O84S6Forma y color:SolidPeso molecular:5971.76[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
CAS:<p>Insulin Receptor (1142-1153) binds insulin, is a substrate for its kinase, and has research/medical potential.</p>Fórmula:C72H110N19O33P3Pureza:98%Forma y color:SolidPeso molecular:1862.67[D-Ala2]-GIP (human)
CAS:<p>Potent GIP receptor agonist with 630 pM EC50; enhances cAMP, glucose control, insulin, cognition in diabetic/obese animals; neuroprotective in PD model.</p>Fórmula:C226H338N60O66SPureza:98%Forma y color:SolidPeso molecular:4983.58IGF-1R inhibitor-2
CAS:<p>IGF-1R inhibitor-2 blocks the insulin-like growth factor-1 receptor, potentially reversing tumor cell transformation and increasing apoptosis susceptibility.</p>Fórmula:C24H24FN7O2Forma y color:SolidPeso molecular:461.501GIP (1-30) amide,human
CAS:<p>GIP (1-30) amide (Human) is a glucose-dependent insulinotropic polypeptide that stimulates insulin secretion, reducing postprandial glycemic issues.</p>Fórmula:C162H240N40O47SPureza:98%Forma y color:SolidPeso molecular:3531.94Valanafusp alfa
CAS:<p>Valanafusp alfa (AGT-181) is a fusion protein targeting HIR and IDUA for MPS I research.</p>Forma y color:LiquidWAY-270250
CAS:<p>WAY-270250 is an IGF-1R/SRC inhibitor.</p>Fórmula:C18H16N2O2Pureza:99.77%Forma y color:SoildPeso molecular:292.33ZIGIR
<p>ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.</p>Fórmula:C39H40N6O3Pureza:98.34% - 99.32%Forma y color:SolidPeso molecular:640.77Acetyl Gastric Inhibitory Peptide (human)
CAS:<p>Acetyl Gastric Inhibitory Peptide: improved insulinotropic, antihyperglycemic, for diabetes/obesity research.</p>Fórmula:C228H340N60O67SForma y color:SolidPeso molecular:5025.6Insulin peglispro
CAS:<p>Insulin peglispro (BIL) is a basal insulin with a stable, extended activity and may offer improved blood sugar control.</p>Fórmula:C370H566N104O110S4Forma y color:SolidPeso molecular:8359.32(Pro3) GIP, human
CAS:<p>(Pro3) GIP, human: stable hGIPR full agonist, high affinity (Ki/Kd=0.90nM), for obesity-related diabetes research.</p>Fórmula:C226H338N60O64SForma y color:SolidPeso molecular:4951.53DA-JC4
CAS:<p>DA-JC4: dual GLP-1/GIP agonist, for neurological disease research and insulin pathway studies.</p>Fórmula:C225H346N56O65Forma y color:SolidPeso molecular:4875.49Macupatide
CAS:<p>Macupatide is a gastric inhibitory polypeptide (GIP) receptor agonist, utilized in research related to antidiabetic applications.</p>Forma y color:SolidGIP (1-30) amide, porcine TFA
<p>GIP (1-30) amide, porcine TFA: a full GIP receptor agonist, similar to natural GIP(1-42), stimulates insulin, mildly inhibits gastric acid.</p>Forma y color:LiquidNBI-31772
CAS:<p>NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).</p>Fórmula:C17H11NO7Pureza:99.79%Forma y color:SolidPeso molecular:341.27Teprotumumab
CAS:<p>Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.</p>Pureza:SDS-PAGE:95.2%;SEC-HPLC:99.6%Forma y color:LiquidPeso molecular:145.62 kDaCixutumumab
CAS:<p>Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impeding</p>Pureza:98.5% (SDS-PAGE); 97.5% (SEC-HPLC) - 98.5% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:LiquidInsulin efsitora alfa
CAS:<p>Insulin efsitora alfa(LY-3209590) is an IR agonist and a fusion protein that binds a novel single-chain insulin variant to the structural domain of human IgG Fc</p>Pureza:98.3% (SDS-PAGE); 98.1% (SEC-HPLC) - 98.3% (SDS-PAGE); 98.1% (SEC-HPLC)Forma y color:LiquidLDD39
<p>LDD39, a PROTAC targeting the degradation of RET protein, effectively and persistently degrades total RET (tRET) protein in vivo and inhibits phosphorylated RET (pRET) signaling.</p>Fórmula:C55H59F2N11O6Forma y color:SolidPeso molecular:1008.12TAK-778
CAS:<p>TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.</p>Fórmula:C24H28NO7PSPureza:98%Forma y color:SolidPeso molecular:505.52IGF-I (30-41)
CAS:<p>IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).</p>Fórmula:C51H83N19O19Pureza:98%Forma y color:SolidPeso molecular:1266.34TLK19781
CAS:<p>TLK19781 is an insulin receptor modulator.</p>Fórmula:C33H24Cl2N4O13S4Pureza:98%Forma y color:SolidPeso molecular:883.73Proinsulin C-peptide (human)
CAS:<p>C-peptide, a 31-amino acid, links Proinsulin A & B chains for correct folding and function.</p>Fórmula:C129H211N35O48Pureza:98%Forma y color:SolidPeso molecular:3020.26Insulin α-chain (1-13)
CAS:<p>Insulin alpha-chain peptide, amino acids 1-13, T cell-recognized, posttranslationally modified.</p>Fórmula:C66H118N20O22S3Pureza:98%Forma y color:SolidPeso molecular:1639.96PQ401
CAS:<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Fórmula:C18H16ClN3O2Pureza:99.77%Forma y color:SolidPeso molecular:341.79HNMPA
CAS:<p>HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.</p>Fórmula:C11H11O4PPureza:99.18%Forma y color:SolidPeso molecular:238.18IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
<p>The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis</p>Forma y color:Lyophilized PowderPeso molecular:80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.IGF1R/CD221 Protein, Mouse, Recombinant (His)
<p>IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Pureza:> 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLCForma y color:Lyophilized PowderPeso molecular:80.72+23.0 kDa (predicted); 110-140 kDa and 50-65 kDa, corresponding to the α subunit and β subunit respectively (reducing condition, due to glycosylation)IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
<p>The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis</p>Forma y color:Lyophilized PowderPeso molecular:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result.HNMPA-(AM)3
CAS:<p>HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。 此外，HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM，在蚊子和哺乳动物中分别) 具有抑制作用。</p>Fórmula:C20H23O10PPureza:97.22%Forma y color:SolidPeso molecular:454.36IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
<p>The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis</p>Forma y color:Lyophilized PowderPeso molecular:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.Ceritinib
CAS:<p>Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C28H36ClN5O3SPureza:98.52% - 99.77%Forma y color:SolidPeso molecular:558.14MID-1
CAS:<p>MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.</p>Fórmula:C12H11N3O4SPureza:99.39%Forma y color:SolidPeso molecular:293.3AG1024
CAS:<p>AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).</p>Fórmula:C14H13BrN2OPureza:98% - 99.37%Forma y color:SolidPeso molecular:305.17NVP-AEW541
CAS:<p>NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based</p>Fórmula:C27H29N5OPureza:98.7% - 99.86%Forma y color:SolidPeso molecular:439.55BMS-536924
CAS:<p>BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for</p>Fórmula:C25H26ClN5O3Pureza:99.02%Forma y color:SolidPeso molecular:479.96Picropodophyllin
CAS:<p>Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.</p>Fórmula:C22H22O8Pureza:98.88% - 99.62%Forma y color:SolidPeso molecular:414.41
![[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1259.webp&w=3840&q=75)
