IGF-1R
Los inhibidores de IGF-1R son compuestos que se dirigen específicamente al receptor de factor de crecimiento similar a la insulina tipo 1 (IGF-1R), una tirosina quinasa receptora involucrada en el crecimiento, desarrollo y supervivencia celular. La señalización de IGF-1R juega un papel significativo en la progresión del cáncer, lo que hace que estos inhibidores sean valiosos en la investigación oncológica. En CymitQuimica, ofrecemos inhibidores de IGF-1R para apoyar su investigación en biología del cáncer, endocrinología y desarrollo de terapias dirigidas.
Se han encontrado 103 productos de "IGF-1R"
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GIP (3-42), human
CAS:Human GIP (3-42) is a peptide antagonist of GIP receptors, affecting insulin regulation and diabetes research.Fórmula:C214H324N58O63SPureza:95.73%Forma y color:SolidPeso molecular:4749.35Robatumumab
CAS:Robatumumab (Sch 717454) is a fully humanized anti-IGF-1R monoclonal antibody with antitumor activity and antiproliferative activity.Pureza:96.9% (SDS-PAGE); 98.1% (SEC-HPLC) - 96.9% (SDS-PAGE); 98.1% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.56 kDaGIP (human) acetate
GIP (human) acetate boosts insulin, limits gastric acid, affects lipid metabolism, and obesity development.Pureza:98.65%Forma y color:SoildALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Fórmula:C23H28BrN7O3SPureza:98.27%Forma y color:SolidPeso molecular:562.48Ref: TM-T10285
1mg50,00€5mg110,00€1mL*10mM (DMSO)136,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€Ganitumab
CAS:Ganitumab (AMG 479) is a potent monoclonal antibody targeting IGF1R with 0.22 nM affinity; used in cancer research.Pureza:100% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:145.70 kDaAZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Fórmula:C27H32ClN7O2Pureza:99.65%Forma y color:SolidPeso molecular:522.04MSDC-0602K
CAS:MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.Fórmula:C19H16KNO5SPureza:99.42%Forma y color:SolidPeso molecular:409.5Valanafusp alfa
CAS:Valanafusp alfa (AGT-181) is a fusion protein targeting HIR and IDUA for MPS I research.Forma y color:LiquidXenin-8
CAS:neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effectsFórmula:C51H79N15O9Pureza:98%Forma y color:SolidPeso molecular:1046.27HNMPA
CAS:HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.
Fórmula:C11H11O4PPureza:99.18%Forma y color:SolidPeso molecular:238.18Ref: TM-T21761
1mg50,00€2mg65,00€5mg93,00€10mg144,00€25mg301,00€50mg452,00€100mg660,00€500mg1.396,00€Gastric Inhibitory Peptide (1-42) (porcine) TFA
Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.Fórmula:C225H342N60O66S·XCF3COOHForma y color:SolidPeso molecular:4975.55[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
CAS:Insulin Receptor (1142-1153) binds insulin, is a substrate for its kinase, and has research/medical potential.Fórmula:C72H110N19O33P3Pureza:98%Forma y color:SolidPeso molecular:1862.67[D-Ala2]-GIP (human)
CAS:Potent GIP receptor agonist with 630 pM EC50; enhances cAMP, glucose control, insulin, cognition in diabetic/obese animals; neuroprotective in PD model.Fórmula:C226H338N60O66SPureza:98%Forma y color:SolidPeso molecular:4983.58Insulin efsitora alfa
CAS:Insulin efsitora alfa(LY-3209590) is an IR agonist and a fusion protein that binds a novel single-chain insulin variant to the structural domain of human IgG FcPureza:98.3% (SDS-PAGE); 98.1% (SEC-HPLC) - 98.3% (SDS-PAGE); 98.1% (SEC-HPLC)Forma y color:LiquidPeso molecular:32.04 kDaGIP (1-39)
CAS:Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.Fórmula:C210H316N56O61SPureza:98%Forma y color:SolidPeso molecular:4633.21[Pro3]-GIP (Mouse)
GIP receptor blocker, 2.6μM IC50, hinders insulin release, regulates glucose in ob/ob mice, and enhances glucose tolerance.Fórmula:C225H342N62O64SPureza:98%Forma y color:SolidPeso molecular:4971.62Insulin sensitizer C59
CAS:Insulin sensitizer C59 is an orally available insulin sensitizer that improves glucose uptake and can be used to study insulin-stimulated GLUT4 translocation.Fórmula:C16H18Cl2N2OPureza:99.98%Forma y color:SoildPeso molecular:325.23INSR agonist 1
INSR agonist 1, an insulin receptor (INSR) agonist, effectively elevates INSR pY1355/1361 levels and exhibits synergistic effects with insulin.Fórmula:C36H47BrN4O6Forma y color:SolidPeso molecular:711.69Insulin peglispro
CAS:Insulin peglispro (BIL) is a basal insulin with a stable, extended activity and may offer improved blood sugar control.Fórmula:C370H566N104O110S4Forma y color:SolidPeso molecular:8359.32AVE1642
AVE1642 is a human IgG monoclonal antibody (mAb) that specifically targets CD221/IGF1R. It has the ability to slow the growth of tumor xenografts and extend the survival of tumor-bearing nude mice. AVE1642 is applicable in the study of advanced solid tumors. Recommended isotype control: HumanIgG1kappa, Isotype Control.Forma y color:Odour LiquidGIP (1-30) amide, porcine TFA
GIP (1-30) amide, porcine TFA: a full GIP receptor agonist, similar to natural GIP(1-42), stimulates insulin, mildly inhibits gastric acid.Forma y color:LiquidCPF-7
CAS:CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulationFórmula:C118H193N33O32Forma y color:SolidPeso molecular:2586Teprotumumab
CAS:Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.
Pureza:SDS-PAGE:95.2%;SEC-HPLC:99.6%Forma y color:LiquidPeso molecular:145.62 kDaPQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Fórmula:C18H16ClN3O2Pureza:99.77%Forma y color:SolidPeso molecular:341.79TLK19781
CAS:TLK19781 is an insulin receptor modulator.Fórmula:C33H24Cl2N4O13S4Pureza:98%Forma y color:SolidPeso molecular:883.73IGF-I (24-41)
CAS:IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.Fórmula:C88H133N27O28Pureza:98%Forma y color:SolidPeso molecular:2017.16C-Peptide 2, rat
CAS:C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion.Fórmula:C135H222N38O49Forma y color:SolidPeso molecular:3161.478Cixutumumab
CAS:Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impedingPureza:98.5% (SDS-PAGE); 97.5% (SEC-HPLC) - 98.5% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:146.32 kDacis-NVP-ADW742
CAS:NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Fórmula:C28H31N5OForma y color:SolidPeso molecular:453.59Insulin α-chain (1-13)
CAS:Insulin alpha-chain peptide, amino acids 1-13, T cell-recognized, posttranslationally modified.Fórmula:C66H118N20O22S3Pureza:98%Forma y color:SolidPeso molecular:1639.96GIP, human
CAS:Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.
Fórmula:C226H338N60O66SPureza:98%Forma y color:SolidPeso molecular:4983.6WAY-270250
CAS:WAY-270250 is an IGF-1R/SRC inhibitor.Fórmula:C18H16N2O2Pureza:99.97%Forma y color:SoildPeso molecular:292.33Proinsulin C-peptide (human)
CAS:C-peptide, a 31-amino acid, links Proinsulin A & B chains for correct folding and function.Fórmula:C129H211N35O48Pureza:98%Forma y color:SolidPeso molecular:3020.26GIP (1-30) amide,human
CAS:GIP (1-30) amide (Human) is a glucose-dependent insulinotropic polypeptide that stimulates insulin secretion, reducing postprandial glycemic issues.Fórmula:C162H240N40O47SPureza:98%Forma y color:SolidPeso molecular:3531.94IGF-I (30-41)
CAS:IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).Fórmula:C51H83N19O19Pureza:98%Forma y color:SolidPeso molecular:1266.34ZIGIR
ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.Fórmula:C39H40N6O3Pureza:98.34% - 99.32%Forma y color:SolidPeso molecular:640.77GIP (3-42), human acetate
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolismPureza:98%Forma y color:LiquidAcetyl Gastric Inhibitory Peptide (human)
CAS:Acetyl Gastric Inhibitory Peptide: improved insulinotropic, antihyperglycemic, for diabetes/obesity research.Fórmula:C228H340N60O67SForma y color:SolidPeso molecular:5025.6IGF-1R inhibitor-2
CAS:IGF-1R inhibitor-2 blocks the insulin-like growth factor-1 receptor, potentially reversing tumor cell transformation and increasing apoptosis susceptibility.Fórmula:C24H24FN7O2Forma y color:SolidPeso molecular:461.501(Pro3) GIP, human
CAS:(Pro3) GIP, human: stable hGIPR full agonist, high affinity (Ki/Kd=0.90nM), for obesity-related diabetes research.Fórmula:C226H338N60O64SForma y color:SolidPeso molecular:4951.53DA-JC4
CAS:DA-JC4: dual GLP-1/GIP agonist, for neurological disease research and insulin pathway studies.Fórmula:C225H346N56O65Forma y color:SolidPeso molecular:4875.49Macupatide
CAS:Macupatide is a gastric inhibitory polypeptide (GIP) receptor agonist, utilized in research related to antidiabetic applications.Forma y color:SolidLDD39
LDD39, a PROTAC targeting the degradation of RET protein, effectively and persistently degrades total RET (tRET) protein in vivo and inhibits phosphorylated RET (pRET) signaling.Fórmula:C55H59F2N11O6Forma y color:SolidPeso molecular:1008.12NBI-31772
CAS:NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).Fórmula:C17H11NO7Pureza:99.79%Forma y color:SolidPeso molecular:341.27OI338
OI338 is an orally available, ultralong-acting insulin analogue.Fórmula:C260H403N65O84S6Forma y color:SolidPeso molecular:5971.76TAK-778
CAS:TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.Fórmula:C24H28NO7PSPureza:98%Forma y color:SolidPeso molecular:505.52Xenin 8 acetate
Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family.Fórmula:C53H83N15O11Pureza:95.54%Forma y color:SoildPeso molecular:1106.32Insulin glulisine
CAS:Insulin glulisine (HMR 1964), a rapid-acting analogue, mimics human insulin; used in diabetes research.Fórmula:C258H384N64O78S6Forma y color:SolidPeso molecular:5822.57Proinsulin C-Peptide (55-89), human
CAS:Proinsulin, insulin's precursor, has A and B chains linked by a 31 amino acid C-peptide. Enzymes cleave it, yielding insulin and C-peptide.Fórmula:C153H259N49O52Pureza:98%Forma y color:SolidPeso molecular:3616.99HNMPA-(AM)3
CAS:HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。 此外，HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM，在蚊子和哺乳动物中分别) 具有抑制作用。Fórmula:C20H23O10PPureza:97.22%Forma y color:SolidPeso molecular:454.36
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