IGF-1R

ALK inhibitor 1 is a selective ALK kinase inhibitor.

AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

HNMPA is a membrane impermeable inhibitor of insulin receptor tyrosine kinase. HNMPA inhibits tyrosine and …

Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family. Xenin …

AVJ16 as a member of the insulin growth factor 2 mRNA-binding protein family, binds to …

Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 …

Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and …

GIP (human) acetate is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of …

PQ401 suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).

NBI-31772 is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 …

Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane …

GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .

GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and …

MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of …

Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).

Picropodophyllin (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity …

NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity …

AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).

PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 …

BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for …

Lenaldekar inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 …

Brigatinib is a highly potent and selective ALK inhibitor.

AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, …

GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 …

SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 …

PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.

Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 …

GIP (1-30) amide, porcine acetate is an agonist of fully glucose-dependent insulinotropic polypeptide (GIP) receptor. …

OSI-906 (Linsitinib) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 …

NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 …

PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, …

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R …

INSULIN is a polypeptide hormone that regulates the level of glucose.

Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and …

NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit …

Insulin cattle (Insulin from bovine pancreas) is a two-chain polypeptide hormone produced in vivo in …

MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association …

1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. …

Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a …

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and …

AZD3463, an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.

AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM …

MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.

Rhoifolin is extracted from Turpinia arguya Seem dried leaves.

Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of …

AGL-2263 is a blocker of insulin receptor (IR)