IGF-1R
Los inhibidores de IGF-1R son compuestos que se dirigen específicamente al receptor de factor de crecimiento similar a la insulina tipo 1 (IGF-1R), una tirosina quinasa receptora involucrada en el crecimiento, desarrollo y supervivencia celular. La señalización de IGF-1R juega un papel significativo en la progresión del cáncer, lo que hace que estos inhibidores sean valiosos en la investigación oncológica. En CymitQuimica, ofrecemos inhibidores de IGF-1R para apoyar su investigación en biología del cáncer, endocrinología y desarrollo de terapias dirigidas.
Se han encontrado 86 productos de "IGF-1R"
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NBI-31772 hydrate
<p>NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.</p>Fórmula:C17H13NO8Forma y color:SolidPeso molecular:372.82Linsitinib
CAS:<p>OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.</p>Fórmula:C26H23N5OPureza:99.71% - ≥95%Forma y color:SolidPeso molecular:421.49AZD-3463
CAS:<p>AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.</p>Fórmula:C24H25ClN6OPureza:99.13%Forma y color:SolidPeso molecular:448.95BRD7552
CAS:<p>BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.</p>Fórmula:C33H33N3O15Pureza:>99.99% - ≥98%Forma y color:SolidPeso molecular:711.63PQ401 hydrochloride (196868-63-0(free base))
<p>PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.</p>Fórmula:C18H17Cl2N3O2Pureza:99.86%Forma y color:SolidPeso molecular:378.25MSDC 0160
CAS:<p>MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.</p>Fórmula:C19H18N2O4SPureza:98.11% - 99.53%Forma y color:SolidPeso molecular:370.42Indirubin Derivative E804
CAS:<p>Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.</p>Fórmula:C20H19N3O4Pureza:98.54%Forma y color:SolidPeso molecular:365.38GSK1904529A
CAS:<p>GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .</p>Fórmula:C44H47F2N9O5SPureza:98.2% - 99.38%Forma y color:SolidPeso molecular:851.96Dusigitumab
CAS:<p>Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.</p>Pureza:95% - 95%Forma y color:LiquidFigitumumab
CAS:<p>Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.</p>Pureza:95%Forma y color:LiquidVeligrotug
CAS:<p>Veligrotug is an IV anti-IGF-1R antibody for thyroid eye disease, reducing diplopia and orbital inflammation, supporting autoimmune ophthalmopathy research.</p>Pureza:95% - 95%Forma y color:LiquidAnti-IGFBP2 Antibody (M14)
<p>Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.</p>Forma y color:Odour LiquidS961
CAS:<p>S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.</p>Fórmula:C211H297N55O71S2Pureza:98%Forma y color:SolidPeso molecular:4804.13BMS-754807
CAS:<p>BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.</p>Fórmula:C23H24FN9OPureza:99.69% - 99.94%Forma y color:SolidPeso molecular:461.49D-(+)-Sorbose
CAS:<p>D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.</p>Fórmula:C6H12O6Forma y color:SolidPeso molecular:180.16BM-131246
CAS:<p>BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.</p>Fórmula:C22H20N2O4SPureza:>99.99%Forma y color:SolidPeso molecular:408.47AZ12253801
CAS:<p>AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.</p>Fórmula:C21H22N8OPureza:98%Forma y color:SolidPeso molecular:402.45KU14R
CAS:<p>KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.</p>Fórmula:C13H14N2OPureza:98%Forma y color:White SolidPeso molecular:214.26I-OMe-Tyrphostin AG 538
CAS:<p>I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.</p>Fórmula:C17H12INO5Pureza:98.23%Forma y color:SolidPeso molecular:437.19Protonstatin-1
CAS:<p>Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.</p>Fórmula:C8H5NO2S2Pureza:99.77%Forma y color:SolidPeso molecular:211.26
