IGF-1R
Los inhibidores de IGF-1R son compuestos que se dirigen específicamente al receptor de factor de crecimiento similar a la insulina tipo 1 (IGF-1R), una tirosina quinasa receptora involucrada en el crecimiento, desarrollo y supervivencia celular. La señalización de IGF-1R juega un papel significativo en la progresión del cáncer, lo que hace que estos inhibidores sean valiosos en la investigación oncológica. En CymitQuimica, ofrecemos inhibidores de IGF-1R para apoyar su investigación en biología del cáncer, endocrinología y desarrollo de terapias dirigidas.
Se han encontrado 106 productos para "IGF-1R".
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GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Fórmula:C27H29FN8O3Pureza:98.89% - >99.99%Forma y color:Yellow SolidPeso molecular:532.57NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFórmula:C27H29N5OPureza:98.7% - 99.86%Forma y color:White SolidPeso molecular:439.55NVP-ADW742
CAS:NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-AblFórmula:C28H31N5OPureza:96.14% - 98.70%Forma y color:White SolidPeso molecular:453.58NT157
CAS:NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Fórmula:C16H14BrNO5SPureza:99.64%Forma y color:SolidPeso molecular:412.26Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Fórmula:C42H70O12Pureza:98% - 99.65%Forma y color:White SolidPeso molecular:767.00Ref: TM-T6S1487
1mg107,00€5mg251,00€1mL*10mM (DMSO)341,00€10mg404,00€25mg665,00€50mg888,00€100mg1.251,00€Insulin(cattle)
CAS:Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.Fórmula:C254H377N65O75S6Pureza:98%Forma y color:White SolidPeso molecular:5733.49NBI-31772 hydrate
NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.Fórmula:C17H13NO8Forma y color:SolidPeso molecular:372.82Linsitinib
CAS:OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.Fórmula:C26H23N5OPureza:98.31% - ≥95%Forma y color:SolidPeso molecular:421.49AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Fórmula:C24H25ClN6OPureza:99.13% - 99.97%Forma y color:Cyan SolidPeso molecular:448.95AG1024
CAS:AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).Fórmula:C14H13BrN2OPureza:98% - 99.37%Forma y color:SolidPeso molecular:305.17MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Fórmula:C12H11N3O4SPureza:99.39%Forma y color:SolidPeso molecular:293.3Ref: TM-T8773
1mg52,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg138,00€25mg245,00€50mg363,00€100mg515,00€200mg700,00€BRD7552
CAS:BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.Fórmula:C33H33N3O15Pureza:>99.99% - ≥98%Forma y color:SolidPeso molecular:711.63Sari 59-801
CAS:Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release.Fórmula:C18H23N3O2Pureza:99.92%Forma y color:SolidPeso molecular:313.39Ref: TM-T34532
1mg34,00€5mg107,00€1mL*10mM (DMSO)108,00€10mg167,00€25mg263,00€50mg366,00€100mg492,00€Glymidine
CAS:Glycodiazine, a sulfadiazine derivative, reduces blood sugar by boosting insulin release and sensitivity.Fórmula:C13H15N3O4SForma y color:SolidPeso molecular:309.34GIP (1-30) amide, porcine acetate
GIP (1-30) amide, porcine is a GIP receptor agonist that stimulates insulin and mildly inhibits gastric acid.Fórmula:C164H249N41O49SPureza:98.50%Forma y color:SolidPeso molecular:3611.04Glymidine sodium
CAS:Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion.Fórmula:C13H14N3NaO4SPureza:98.19%Forma y color:SolidPeso molecular:331.32PQ401 hydrochloride (196868-63-0(free base))
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.Fórmula:C18H17Cl2N3O2Pureza:99.67%Forma y color:SolidPeso molecular:378.25MSDC 0160
CAS:MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.Fórmula:C19H18N2O4SPureza:99.53% - 99.78%Forma y color:SolidPeso molecular:370.42Ref: TM-T2607
1mg34,00€2mg48,00€5mg73,00€1mL*10mM (DMSO)78,00€10mg94,00€25mg145,00€50mg187,00€100mg333,00€MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Fórmula:C21H18N2OPureza:98.53% - 99.90%Forma y color:Red SolidPeso molecular:314.38XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Fórmula:C22H31N9OPureza:99.07%Forma y color:SolidPeso molecular:437.54Ref: TM-T17267
1mg52,00€2mg73,00€5mg94,00€1mL*10mM (DMSO)104,00€10mg141,00€25mg244,00€50mg371,00€100mg552,00€
