IGF-1R
Los inhibidores de IGF-1R son compuestos que se dirigen específicamente al receptor de factor de crecimiento similar a la insulina tipo 1 (IGF-1R), una tirosina quinasa receptora involucrada en el crecimiento, desarrollo y supervivencia celular. La señalización de IGF-1R juega un papel significativo en la progresión del cáncer, lo que hace que estos inhibidores sean valiosos en la investigación oncológica. En CymitQuimica, ofrecemos inhibidores de IGF-1R para apoyar su investigación en biología del cáncer, endocrinología y desarrollo de terapias dirigidas.
Se han encontrado 103 productos de "IGF-1R"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Picropodophyllin
CAS:Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.Fórmula:C22H22O8Pureza:98.38% - 99.83%Forma y color:SolidPeso molecular:414.41Ref: TM-T6943
5mg64,00€1mL*10mM (DMSO)69,00€10mg88,00€25mg170,00€50mg316,00€100mg535,00€500mg1.121,00€BMS-536924
CAS:BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity forFórmula:C25H26ClN5O3Pureza:99.02%Forma y color:SolidPeso molecular:479.96GSK1904529A
CAS:GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .Fórmula:C44H47F2N9O5SPureza:98.2% - 99.76%Forma y color:SolidPeso molecular:851.96Indirubin Derivative E804
CAS:Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.Fórmula:C20H19N3O4Pureza:98.54%Forma y color:SolidPeso molecular:365.38Ref: TM-T11654
1mg42,00€5mg88,00€1mL*10mM (DMSO)93,00€10mg124,00€25mg197,00€50mg293,00€100mg434,00€200mg622,00€Anti-IGFBP2 Antibody (M14)
Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.Forma y color:Odour LiquidFigitumumab
CAS:Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.Pureza:95%Forma y color:LiquidPeso molecular:~150 kDaDusigitumab
CAS:Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.Pureza:95% - 96.5% (SDS-PAGE); 97.1 % (SEC-HPLC)Forma y color:LiquidPeso molecular:144.22 kDaS961
CAS:S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.Fórmula:C211H297N55O71S2Pureza:98%Forma y color:SolidPeso molecular:4804.13BMS-754807
CAS:BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Fórmula:C23H24FN9OPureza:99.69% - 99.94%Forma y color:SolidPeso molecular:461.49Ref: TM-T2349
1mg50,00€2mg66,00€5mg90,00€1mL*10mM (DMSO)110,00€10mg158,00€25mg310,00€50mg509,00€100mg732,00€D-(+)-Sorbose
CAS:D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.Fórmula:C6H12O6Forma y color:SolidPeso molecular:180.16KU14R
CAS:KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.Fórmula:C13H14N2OPureza:98%Forma y color:White SolidPeso molecular:214.26AZ12253801
CAS:AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.Fórmula:C21H22N8OPureza:98%Forma y color:SolidPeso molecular:402.45H-1356
CAS:H-1356 is an insulin-like growth factor 1(IGF-I) analog that inhibits autophosphorylation of IGF-I receptor.Fórmula:C55H88N14O15S2Forma y color:SolidPeso molecular:1249.5IMP2-IN-2
CAS:IMP2-IN-2: potent, selective IMP2 inhibitor; IC50s: 120.9 μM (RNA_A), 236.7 μM (RNA_B); used in cancer research.Fórmula:C22H19F3N2O3SForma y color:SolidPeso molecular:448.46BM-131246
CAS:BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.Fórmula:C22H20N2O4SPureza:>99.99%Forma y color:SolidPeso molecular:408.47I-OMe-Tyrphostin AG 538
CAS:I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.Fórmula:C17H12INO5Pureza:98.8%Forma y color:SolidPeso molecular:437.19Ref: TM-T11593
1mg56,00€5mg119,00€1mL*10mM (DMSO)131,00€10mg187,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Fórmula:C16H14BrNO5SPureza:98.06% - 99.72%Forma y color:SolidPeso molecular:412.26Protonstatin-1
CAS:Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.Fórmula:C8H5NO2S2Pureza:99.77%Forma y color:SolidPeso molecular:211.26Ref: TM-T71812
1mg90,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg313,00€25mg537,00€50mg713,00€100mg982,00€200mg1.333,00€NBI-6024
CAS:NBI-6024, an altered peptide ligand (APL), serves as an epitope for interferon-gamma-producing T helper lymphocytes associated with inflammation in patientsFórmula:C66H112N20O21Forma y color:SolidPeso molecular:1521.72BMS-695735
CAS:BMS-695735: benzimidazole, inhibits IGF-1 receptor, broad antitumor effects, affects CYP3A4, low solubility, binds plasma proteins.Fórmula:C26H31ClFN7OForma y color:SolidPeso molecular:512.02
