Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Se han encontrado 97 productos de "Ubiquitinación"
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WS-383
CAS:WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Fórmula:C18H21Cl2N9S2Pureza:98.46%Forma y color:SolidPeso molecular:498.46Ref: TM-T13349
1mg46,00€2mg58,00€5mg87,00€10mg144,00€25mg283,00€50mg558,00€100mg797,00€500mg1.634,00€1mL*10mM (DMSO)97,00€MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Fórmula:C30H37N3O4SPureza:99.93%Forma y color:SolidPeso molecular:535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€200mg934,00€1mL*10mM (DMSO)104,00€ML-792
CAS:ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Fórmula:C21H23BrN6O5SPureza:99.32% - 99.82%Forma y color:SolidPeso molecular:551.41Ref: TM-T16102
1mg87,00€2mg113,00€5mg177,00€10mg260,00€25mg409,00€50mg560,00€100mg800,00€1mL*10mM (DMSO)225,00€TAS4464 hydrochloride
CAS:TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).Fórmula:C21H24ClFN6O6SPureza:98.61% - 98.96%Forma y color:SolidPeso molecular:542.97Ref: TM-T13090
1mg66,00€5mg144,00€10mg227,00€25mg455,00€50mg753,00€100mg1.301,00€1mL*10mM (DMSO)167,00€NSC232003
CAS:NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Fórmula:C6H7N3O3Pureza:97.72%Forma y color:SolidPeso molecular:169.14C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Fórmula:C17H8FNO3Pureza:97.22%Forma y color:SolidPeso molecular:293.25IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。Fórmula:C19H23ClN2OPureza:98.94%Forma y color:SolidPeso molecular:330.85Ref: TM-T15604
1mg35,00€5mg67,00€10mg115,00€25mg235,00€50mg378,00€100mg627,00€200mg875,00€1mL*10mM (DMSO)73,00€HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
Fórmula:C25H28ClN3OPureza:97.71%Forma y color:SolidPeso molecular:421.96USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.
Fórmula:C19H20ClF3N4OSPureza:99.92%Forma y color:SolidPeso molecular:444.9Cbl-b-IN-18
Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ubiquitin ligase Cbl-b, effectively blocking Cbl-b phosphorylation with an IC50 of less than 100 nM.Fórmula:C33H31F4N7OPeso molecular:617.25262RNF5 agonist 1
CAS:RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.Fórmula:C22H18N4SForma y color:SolidPeso molecular:370.47Cbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ubiquitin ligase Cbl, demonstrating an IC50 of 15 nM. Cbl-b refers to Casitas B-lineage Lymphoma proto-oncogene-b, which can inhibit the activation of T cells, natural killer (NK) cells, and B cells. Cbl-b-IN-15 can activate T cell function with an EC50 of 0.41 μM.Fórmula:C27H27N5O3Peso molecular:469.21139Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Forma y color:Odour SolidUbiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Forma y color:Odour SolidRef: TM-L8600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarPost-Translational Modification Compound Library
Contains xnum active small molecules for research related to post-translational modifications (PTMs);
Forma y color:Odour SolidRef: TM-L1620
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultardCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Fórmula:C14H11ClN4OSPureza:98.48% - 99.41%Forma y color:SolidPeso molecular:318.78SAE-IN-2
SAE-IN-2 (compound 6) is a potent inhibitor of sumoylation-activating enzyme (SAE) with an IC50 value of 27.8 nM.Fórmula:C27H30ClN5O5S2Peso molecular:603.13769Rugonersen sodium
CAS:Rugonersen sodium is a locked nucleic acid (LNA)-modified antisense oligonucleotide (ASO) designed to reduce the silencing of ubiquitin protein ligase E3A (UBE3A). Angelman syndrome (AS) refers to a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, and Rugonersen has been studied for its potential use in the treatment of AS.Fórmula:C204H235N63Na19O109P19S19Peso molecular:6948.00OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFórmula:C22H17Cl2FN2O4Pureza:99.92%Forma y color:SolidPeso molecular:463.29UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C17H17ClN4O2Forma y color:SolidPeso molecular:344.8
