Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Se han encontrado 107 productos de "Ubiquitinación"
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ML240
CAS:<p>ML240 is a selective, ATP-competitive p97 inhibitor.</p>Fórmula:C23H20N6OPureza:99.73% - >99.99%Forma y color:SolidPeso molecular:396.44MID-1
CAS:<p>MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.</p>Fórmula:C12H11N3O4SPureza:99.39%Forma y color:SolidPeso molecular:293.3USP7/USP47 inhibitor
CAS:<p>USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,</p>Fórmula:C18H11Cl2N3O3S3Pureza:98.5% - 98.71%Forma y color:SolidPeso molecular:484.4WSB1 Degrader 1
CAS:<p>WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.</p>Fórmula:C21H22N2O2Pureza:98.57%Forma y color:SolidPeso molecular:334.41VLX1570
CAS:<p>VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.</p>Fórmula:C23H17F2N3O6Pureza:98.53% - 99.91%Forma y color:SolidPeso molecular:469.39ML-323
CAS:<p>ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.</p>Fórmula:C23H24N6Pureza:99.87% - 99.96%Forma y color:SolidPeso molecular:384.48NMS-873
CAS:<p>NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.</p>Fórmula:C27H28N4O3S2Pureza:99.05% - 99.85%Forma y color:SolidPeso molecular:520.67PR-619
CAS:<p>PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.</p>Fórmula:C7H5N5S2Pureza:97.25% - >99.99%Forma y color:SolidPeso molecular:223.282-D08
CAS:<p>2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.</p>Fórmula:C15H10O5Pureza:98.58% - 98.95%Forma y color:SolidPeso molecular:270.24DUB-IN-1
CAS:<p>DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).</p>Fórmula:C20H11N5OPureza:98.33% - 98.96%Forma y color:SolidPeso molecular:337.33CB-5083
CAS:<p>CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).</p>Fórmula:C24H23N5O2Pureza:95.95% - 99.92%Forma y color:SolidPeso molecular:413.47Skp2 Inhibitor C1
CAS:<p>Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.</p>Fórmula:C18H13BrN2O4S2Pureza:97.36%Forma y color:SolidPeso molecular:465.34ML364
CAS:<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Fórmula:C24H18F3N3O3S2Pureza:99.35% - >99.99%Forma y color:SolidPeso molecular:517.54BC-1382
CAS:<p>BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).</p>Fórmula:C23H29N3O5SPureza:99.15% - 99.94%Forma y color:SolidPeso molecular:459.56NSC632839
CAS:<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Fórmula:C21H22ClNOPureza:99.74% - 99.88%Forma y color:SolidPeso molecular:339.86SJB2-043
CAS:<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Fórmula:C17H9NO3Pureza:98.44%Forma y color:SolidPeso molecular:275.26DUB-IN-2
CAS:<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Fórmula:C15H9N5OPureza:98.96%Forma y color:SolidPeso molecular:275.26GNE-6640
CAS:<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Fórmula:C20H18N4OPureza:98.64%Forma y color:SolidPeso molecular:330.38USP7-IN-8
CAS:<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Fórmula:C21H21N3O2Pureza:99.31%Forma y color:SolidPeso molecular:347.41Subasumstat
CAS:<p>Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.</p>Fórmula:C25H28ClN5O5S2Pureza:97.02% - 98.22%Forma y color:SolidPeso molecular:578.1
