Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Se han encontrado 71 productos para "Ubiquitinación".
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Smurf1-IN-1
CAS:Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFórmula:C24H29ClN6O2Pureza:98%Forma y color:SolidPeso molecular:468.98UP158
CAS:UP158 is a VCP small-molecule activator (EC₅₀=2.57 μM) that enhances ATPase activity for protein degradation and neurodegenerative disease studies.Fórmula:C17H17ClN4O2Forma y color:SolidPeso molecular:344.795UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Fórmula:C20H15ClN2O5SForma y color:SolidPeso molecular:430.86NSC624206
CAS:NSC624206, an asymmetric disulfide, selectively inhibits UBA1, blocks p27 ubiquitination in vitro, and elevates p27 levels in HepG2 cells.Fórmula:C19H33Cl2NS2Pureza:98%Forma y color:SolidPeso molecular:410.51CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Fórmula:C24H24N6OPureza:97.66%Forma y color:SolidPeso molecular:412.487Ubiquitination-IN-1
CAS:Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Fórmula:C21H14F3N3O2SPureza:98.39% - 99.88%Forma y color:SolidPeso molecular:429.415PYZD-4409
CAS:PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.Fórmula:C14H7ClFN3O5Pureza:99.71%Forma y color:SolidPeso molecular:351.674CC0651
CAS:CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).Fórmula:C20H21Cl2NO6Pureza:99.03%Forma y color:White SolidPeso molecular:442.29Cbl-b-IN-13
CAS:Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].Fórmula:C29H30F3N5O2Pureza:98%Forma y color:SolidPeso molecular:537.58Cbl-b-IN-10
CAS:Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (Fórmula:C31H37F3N6OPureza:98%Forma y color:SolidPeso molecular:566.66Cbl-b-IN-12
CAS:Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100Fórmula:C28H29F3N6O2Pureza:98%Forma y color:SolidPeso molecular:538.56DI-591
CAS:DI-591 selectively inhibits DCN1-UBC12 interaction and cullin 3 neddylation.Fórmula:C31H47N5O4SForma y color:White SolidPeso molecular:585.801UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Fórmula:C30H32F2N6O3SPureza:98%Forma y color:SolidPeso molecular:594.68UC-764864
CAS:UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFórmula:C19H18N2OSPureza:99.3%Forma y color:SolidPeso molecular:322.42PRC1-IN-1
CAS:PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.Fórmula:C24H19ClFN3O2Forma y color:SolidPeso molecular:435.878Cbl-b-IN-26
CAS:Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a dissociation constant (Kd) of 34.6 nM. It is used in the research of chronic viral infections and cancer.Fórmula:C21H19F3N6Forma y color:SolidPeso molecular:412.41Cbl-b-IN-6
CAS:Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (Fórmula:C30H32F5N5OPureza:98%Forma y color:SolidPeso molecular:573.6NSC20116
CAS:NSC20116 is a uracil derivative that specifically targets the Set-and-Ring (SRA) domain of the oncogene UHRF1. It binds to the 5-methylcytosine (5mC) recognition pocket within the UHRF1SRA domain, with a dissociation constant (Kd) of 362 nM. NSC20116 is applicable for cancer research.Fórmula:C4H4N4O3Peso molecular:156.1Cbl-b-IN-9
CAS:Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFórmula:C30H33F3N6O2Pureza:98%Forma y color:SolidPeso molecular:566.62Yucasin
CAS:Yucasin is a highly potent inhibitor of auxin (IAA) biosynthesis that blocks the tryptophan-dependent pathway by specifically inhibiting the activity of YUCCA.Fórmula:C8H6ClN3SPureza:95.10% - 98.90%Forma y color:White SolidPeso molecular:211.671
