Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Se han encontrado 71 productos para "Ubiquitinación".
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ML-792
CAS:ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Fórmula:C21H23BrN6O5SPureza:99.32% - 99.82%Forma y color:SolidPeso molecular:551.414NSC232003
CAS:NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Fórmula:C6H7N3O3Pureza:97.72%Forma y color:SolidPeso molecular:169.1381WS-383
CAS:WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Fórmula:C18H21Cl2N9S2Pureza:98.46%Forma y color:SolidPeso molecular:498.456Cbl-b-IN-18
Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ubiquitin ligase Cbl-b, effectively blocking Cbl-b phosphorylation with an IC50 of less than 100 nM.Fórmula:C33H31F4N7OForma y color:SolidPeso molecular:617.25262Antitumor agent-153
Antitumor agent-153 (compound 11b) is an inhibitor of H2A histone ubiquitination, optimized from PRT4165. It can reduce the viability of human osteosarcoma U2OS cells and decrease monoubiquitination of histone H2A, demonstrating anticancer activity.Fórmula:C16H8N2O6Forma y color:SolidPeso molecular:324.03824Post-Translational Modification Compound Library
Contains xnum active small molecules for research related to post-translational modifications (PTMs);
Forma y color:Odour SolidCbl-b-IN-19
Cbl-b-IN-19 (Compound 49) is an inhibitor of the E3 ligase Cbl-b, effectively suppressing its phosphorylation with an IC50 of less than 100 nM.Fórmula:C34H31F3N8OForma y color:SolidPeso molecular:624.25729dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.Fórmula:C14H11ClN4OSPureza:98.48% - 99.49%Forma y color:SolidPeso molecular:318.781MRC37
MRC37 is a potent and selective small molecule ligand for TRIM21, binding to the PRYSPRY domain of TRIM21. It inhibits the innate antiviral function of TRIM21 by preventing antibody neutralization of adenovirus 5 (Adv5). Additionally, MRC37 can inhibit the Trim-Away technique, a targeted protein degradation method that recruits TRIM21 to specific proteins via electroporated antibodies.Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Forma y color:Odour SolidCbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ubiquitin ligase Cbl, demonstrating an IC50 of 15 nM. Cbl-b refers to Casitas B-lineage Lymphoma proto-oncogene-b, which can inhibit the activation of T cells, natural killer (NK) cells, and B cells. Cbl-b-IN-15 can activate T cell function with an EC50 of 0.41 μM.Fórmula:C27H27N5O3Forma y color:SolidPeso molecular:469.21139SAE-IN-2
SAE-IN-2 (compound 6) is a potent inhibitor of sumoylation-activating enzyme (SAE) with an IC50 value of 27.8 nM.Fórmula:C27H30ClN5O5S2Forma y color:SolidPeso molecular:603.13769Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Forma y color:Odour SolidMSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Fórmula:C29H29F3N2Forma y color:SolidPeso molecular:462.5492LS-102
CAS:LS-102: E3 ligase inhibitor, IC50 35 μM, potential RA therapy.Fórmula:C24H36N8OPureza:98.92%Forma y color:SolidPeso molecular:452.5956BRD5529
CAS:BRD5529 selective CARD9–TRIM62 interaction inhibitor for ubiquitination pathway regulation, innate immunity, inflammatory signaling and CARD9 immune response research.Fórmula:C25H31N5O4Forma y color:SolidPeso molecular:465.5447NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Fórmula:C27H28N4O3S2Pureza:99.05% - 99.85%Forma y color:SolidPeso molecular:520.666CYM5442
CAS:CYM5442 is an S1P agonist, targeting to Sphingosine.Fórmula:C23H27N3O4Pureza:98.02% - 99.48%Forma y color:White SolidPeso molecular:409.4782Skp2 Inhibitor C1
CAS:Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.Fórmula:C18H13BrN2O4S2Pureza:97.36%Forma y color:SolidPeso molecular:465.341MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Fórmula:C12H11N3O4SPureza:99.39%Forma y color:SolidPeso molecular:293.298
