Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1428 productos de "Autofagia"
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(Rac)-BL-918
CAS:<p>(Rac)-BL-918 is the racemic form of BL-918. BL-918 is an effective activator of UNC-51-like kinase 1 (ULK1) (EC₅₀ = 24.14 nM), Parkinson's disease.</p>Fórmula:C23H15F8N3OSPureza:98%Forma y color:SolidPeso molecular:533.44MPM-1
<p>MPM-1, a marine mimic, induces rapid necrotic-like death in cancer cells, disrupts autophagy, and causes lysosomal swelling.</p>Fórmula:C34H44F6N4O7Forma y color:SolidPeso molecular:734.73SB-332235
CAS:<p>SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.</p>Fórmula:C13H10Cl3N3O4SForma y color:SolidPeso molecular:410.66Autophagy-IN-C1
CAS:<p>Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea.</p>Fórmula:C29H28F6N4O2Forma y color:SolidPeso molecular:578.55IZCZ-3
CAS:<p>IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.</p>Fórmula:C46H49N7OPureza:98%Forma y color:SolidPeso molecular:715.93ICT5040
CAS:<p>ICT5040 is a CXCR4 antagonist.</p>Fórmula:C10H8F3N3OSForma y color:SolidPeso molecular:275.25FAAH-IN-1
CAS:FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.Fórmula:C20H19ClN4OSPureza:98%Forma y color:SolidPeso molecular:398.91Norswertianin
CAS:<p>Norswertianin, a xanthone, induces GBM cell differentiation and autophagy via oxidative stress and Akt/mTOR.</p>Fórmula:C13H8O6Forma y color:SolidPeso molecular:260.2Quinacrine analog 34
CAS:<p>Quinacrine: anti-protozoal, autophagy inhibitor (toxic at 2.5 μM). Analog 34 less toxic (LD50 = 27 μM), raises LC3-II protein, deacidifies lysosomes.</p>Fórmula:C20H27ClN4Forma y color:SolidPeso molecular:358.91VUF11211
CAS:<p>VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.</p>Fórmula:C26H35Cl2N5OPureza:98%Forma y color:SolidPeso molecular:504.49CXCR4 antagonist 9
CAS:<p>CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.</p>Fórmula:C21H27FN6Forma y color:SolidPeso molecular:382.48SMYD3-IN-2
<p>SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.</p>Fórmula:C26H21BrN2O4Forma y color:SolidPeso molecular:505.36AUTEN-67
CAS:<p>AUTEN-67 inhibits MTMR14, boosts autophagy, has antiaging/neuroprotective properties, and combats Huntington's disease onset/severity.</p>Fórmula:C23H14N4O6SForma y color:SolidPeso molecular:474.45CXCR4 modulator-2
CAS:<p>CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.</p>Fórmula:C21H32N8O2Forma y color:SolidPeso molecular:428.53Antiproliferative agent-5
CAS:<p>Compound 4o inhibits gastric cancer growth, blocks G2/M cell cycle, induces ROS, and triggers autophagy. Used in anti-cancer studies.</p>Fórmula:C28H21BrN8OSForma y color:SolidPeso molecular:597.49NSC 33994
CAS:<p>NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.</p>Fórmula:C28H42N2O2Pureza:98%Forma y color:SolidPeso molecular:438.65SR 3677 dihydrochloride
CAS:<p>Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).</p>Fórmula:C22H26Cl2N4O4Forma y color:SolidPeso molecular:481.37CXCR4 antagonist 8
CAS:<p>CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.</p>Fórmula:C21H26N6Forma y color:SolidPeso molecular:362.47Lamotrigine isethionate
CAS:<p>Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.</p>Fórmula:C11H13Cl2N5O4SForma y color:SolidPeso molecular:382.22PF-06371900
CAS:<p>PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).</p>Fórmula:C17H16N6O2SForma y color:SolidPeso molecular:368.41
