Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1428 productos de "Autofagia"
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Ralimetinib
CAS:<p>Ralimetinib blocks MK2 phosphorylation at Thr334 without affecting p38α MAPK or JNK. It is an ATP-competitive inhibitor of p38 MAPK α/β (IC50 5.3/3.2 nM).</p>Fórmula:C24H29FN6Pureza:99.16% - 99.21%Forma y color:SolidPeso molecular:420.53Obatoclax
CAS:<p>Obatoclax (GX15-070), a pan-BCL-2 inhibitor (Ki 220 nM) induces autophagy, degrades cyclin D1, and has anti-cancer/antiparasitic properties.</p>Fórmula:C20H19N3OPureza:99.44%Forma y color:SolidPeso molecular:317.38Ivacaftor benzenesulfonate
CAS:<p>Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.</p>Fórmula:C30H34N2O6SPureza:98%Forma y color:SolidPeso molecular:550.67STK683963
CAS:<p>STK683963 activates ATG4B, mediates redox regulation, and aids cancer research.</p>Fórmula:C12H8FN3O2SForma y color:SolidPeso molecular:277.27PF-06455943
CAS:<p>PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.</p>Fórmula:C17H14FN5OForma y color:SolidPeso molecular:323.32HF51116
CAS:<p>HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.</p>Fórmula:C29H46N8OForma y color:SolidPeso molecular:522.73CC214-2
CAS:<p>CC214-2: strong dual mTORC1/2 inhibitor, blocks autophagy, may shorten TB duration.</p>Fórmula:C20H25N5O3Forma y color:SolidPeso molecular:383.44Poloppin
CAS:<p>Poloppin modulates polo-like kinases, targets mutant KRAS, and enhances Crizotinib's effects against KRAS-mutant cancers.</p>Fórmula:C20H15BrF3NO2Pureza:98%Forma y color:SolidPeso molecular:438.24AS1708727
CAS:<p>AS1708727 inhibits Foxo1, reducing blood sugar and triglycerides by altering gene expression.</p>Fórmula:C24H24Cl2N2O2Forma y color:SolidPeso molecular:443.37Aliskiren fumarate
CAS:<p>Oral renin inhibitor Aliskiren fumarate treats hypertension; IC50: 1.5 nM. Useful for cardiovascular and cancer cachexia research.</p>Fórmula:C34H57N3O10Forma y color:SolidPeso molecular:667.83GLPG2451
CAS:<p>GLPG2451 potentiates F508del CFTR at low temp (EC50: 11.1 nM), aiding cystic fibrosis treatment.</p>Fórmula:C16H16F3N3O5SForma y color:SolidPeso molecular:419.38Dinoprost
CAS:<p>Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.</p>Fórmula:C20H34O5Pureza:97.94% - 98.04%Forma y color:White To Off-White Crystalline SolidPeso molecular:354.48Elliptinium acetate
CAS:<p>Elliptinium acetate (NSC 264137), a cytotoxic DNA intercalator for cancer research, targets L1210 cells.</p>Fórmula:C20H20N2O3Forma y color:SolidPeso molecular:336.38SA72
CAS:<p>SA72 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH).</p>Fórmula:C21H26N2O6Pureza:98%Forma y color:SolidPeso molecular:402.44SX-517
CAS:<p>SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.</p>Fórmula:C19H16BFN2O3SForma y color:SolidPeso molecular:382.22TN-14003
CAS:<p>TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.</p>Fórmula:C90H141N33O18S2Forma y color:SolidPeso molecular:2037.42p38 MAPK-IN-2
CAS:<p>p38 MAPK-IN-2 is an inhibitor of p38 kinase.</p>Fórmula:C20H19ClFN5O2Pureza:98%Forma y color:SolidPeso molecular:415.85(3S,5R)-Rosuvastatin
CAS:<p>(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>Fórmula:C22H28FN3O6SPureza:98%Forma y color:SolidPeso molecular:481.54(S)-Hydroxychloroquine
CAS:<p>(S)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine shows efficiently inhibits SARS-CoV-2 infection in vitro.</p>Fórmula:C18H26ClN3OPureza:98%Forma y color:SolidPeso molecular:335.87KRH-1636
CAS:<p>KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.</p>Fórmula:C32H37N7O2Forma y color:SolidPeso molecular:551.68
