Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1427 productos de "Autofagia"
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Ivacaftor hydrate
CAS:<p>Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.</p>Fórmula:C24H30N2O4Pureza:98%Forma y color:SolidPeso molecular:410.514CXCR4 antagonist 5
CAS:<p>CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.</p>Fórmula:C21H30N6Forma y color:SolidPeso molecular:366.5VUF10132
CAS:<p>VUF10132 is a full inverse CXCR3 N3.35A agonist.</p>Fórmula:C19H13BrCl4N2O2Pureza:98%Forma y color:SolidPeso molecular:523.03Poloppin
CAS:<p>Poloppin modulates polo-like kinases, targets mutant KRAS, and enhances Crizotinib's effects against KRAS-mutant cancers.</p>Fórmula:C20H15BrF3NO2Pureza:98%Forma y color:SolidPeso molecular:438.24PF-06455943
CAS:<p>PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.</p>Fórmula:C17H14FN5OForma y color:SolidPeso molecular:323.32Ivacaftor benzenesulfonate
CAS:<p>Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.</p>Fórmula:C30H34N2O6SPureza:98%Forma y color:SolidPeso molecular:550.67eIF4A3-IN-2
CAS:<p>eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 inhibitor with an IC50 of 110 nM.</p>Fórmula:C25H19Br2ClN4O2Pureza:98%Forma y color:SolidPeso molecular:602.71Ralimetinib
CAS:<p>Ralimetinib blocks MK2 phosphorylation at Thr334 without affecting p38α MAPK or JNK. It is an ATP-competitive inhibitor of p38 MAPK α/β (IC50 5.3/3.2 nM).</p>Fórmula:C24H29FN6Pureza:99.16% - 99.21%Forma y color:SolidPeso molecular:420.53PF-06371900
CAS:<p>PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).</p>Fórmula:C17H16N6O2SForma y color:SolidPeso molecular:368.41Olacaftor
CAS:<p>Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR).</p>Fórmula:C29H34FN3O4SForma y color:SolidPeso molecular:539.66Lamotrigine isethionate
CAS:<p>Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.</p>Fórmula:C11H13Cl2N5O4SForma y color:SolidPeso molecular:382.22SR 3677 dihydrochloride
CAS:<p>Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).</p>Fórmula:C22H26Cl2N4O4Forma y color:SolidPeso molecular:481.37NSC 33994
CAS:<p>NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.</p>Fórmula:C28H42N2O2Pureza:98%Forma y color:SolidPeso molecular:438.65CXCR4 modulator-2
CAS:<p>CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.</p>Fórmula:C21H32N8O2Forma y color:SolidPeso molecular:428.53SMYD3-IN-2
<p>SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.</p>Fórmula:C26H21BrN2O4Forma y color:SolidPeso molecular:505.36Antitumor agent-81
CAS:<p>Antitumor agent-81, a P62-RNF168 agonist, reduces H2A ubiquitination, hinders DNA repair, and inhibits tumor growth.</p>Fórmula:C19H19N7O3Forma y color:SolidPeso molecular:393.4ROC-325
CAS:<p>ROC-325: orally active autophagy inhibitor with anticancer effects, induces kidney cancer cell death; selective action.</p>Fórmula:C28H27ClN4OSPureza:99.26%Forma y color:SolidPeso molecular:503.06MPM-1
<p>MPM-1, a marine mimic, induces rapid necrotic-like death in cancer cells, disrupts autophagy, and causes lysosomal swelling.</p>Fórmula:C34H44F6N4O7Forma y color:SolidPeso molecular:734.73(Rac)-AZD 6482
CAS:<p>(Rac)-AZD 6482 is the racemate of AZD 6482. AZD 6482 is a potent and selective inhibitor of p110β (IC50 of 0.69 nM).</p>Fórmula:C22H24N4O4Forma y color:SolidPeso molecular:408.45K67
CAS:<p>K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.</p>Fórmula:C29H30N2O7S2Pureza:98.43%Forma y color:SolidPeso molecular:582.69
