Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1424 productos de "Autofagia"
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JMS-17-2 hydrochloride
CAS:<p>JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.</p>Fórmula:C25H27Cl2N3OForma y color:SolidPeso molecular:456.41Bergapten
CAS:<p>Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.</p>Fórmula:C12H8O4Pureza:99.48% - ≥95%Forma y color:Needles From Alcohol; Soln In Sulfuric Acid Is Yellow-Gold Physical Description Grayish-White Micr°Crystalline Powder Or Yellow Fluffy Solid (Ntp 1992)Peso molecular:216.19IOWH-032
CAS:<p>IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.</p>Fórmula:C22H15Br2N3O4Pureza:98.92% - ≥95%Forma y color:SolidPeso molecular:545.18Sinomenine
CAS:<p>Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.</p>Fórmula:C19H23NO4Pureza:99.02% - 99.73%Forma y color:White PowderPeso molecular:329.39Momelotinib
CAS:<p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>Fórmula:C23H22N6O2Pureza:97.47% - 99.56%Forma y color:SolidPeso molecular:414.46Tanespimycin
CAS:<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Fórmula:C31H43N3O8Pureza:99.07% - 99.83%Forma y color:Dark Purple SolidPeso molecular:585.69Dantrolene
CAS:<p>Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.</p>Fórmula:C14H10N4O5Pureza:99.97%Forma y color:Crystals From Aq DimethylformamidePeso molecular:314.25Pinocembrin
CAS:<p>Pinocembrin (5,7-Dihydroxyflavanone) is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.</p>Fórmula:C15H12O4Pureza:99.61% - >99.99%Forma y color:SolidPeso molecular:256.25MW-150 dihydrochloride dihydrate
CAS:<p>MW-150: selective CNS-penetrant p38α MAPK inhibitor, orally active, Ki 101 nM, blocks MK2 phosphorylation in glia.</p>Fórmula:C24H29Cl2N5O2Forma y color:SolidPeso molecular:490.43Isorhapontigenin
CAS:<p>Isorhapontigenin: a methoxylated stilbenoid isomer of rhapontigenin, similar to resveratrol, present in Gnetum spp. and Aiphanes aculeata seeds.</p>Fórmula:C15H14O4Pureza:98.49% - 99.85%Forma y color:Off White Crystals PowerPeso molecular:258.27Cediranib
CAS:<p>Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.</p>Fórmula:C25H27FN4O3Pureza:97.21% - 99.94%Forma y color:SolidPeso molecular:450.51Tubastatin A Hydrochloride
CAS:<p>Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM).</p>Fórmula:C20H21N3O2·HClPureza:97.24% - 99.15%Forma y color:SolidPeso molecular:371.86Quizartinib
CAS:<p>Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.</p>Fórmula:C29H32N6O4SPureza:98% - 99.42%Forma y color:SolidPeso molecular:560.67Apigenin
CAS:<p>Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants.</p>Fórmula:C15H10O5Pureza:97.64% - 99.66%Forma y color:Yellow Needles From Aqueous Pyridine SolidPeso molecular:270.24U0126-EtOH
CAS:<p>U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!</p>Fórmula:C18H16N6S2·C2H6OPureza:99.72% - 99.88%Forma y color:SolidPeso molecular:426.6Tenovin-6
CAS:<p>Tenovin-6 is a p53 transcriptional activity agonist.</p>Fórmula:C25H34N4O2SPureza:97.71% - >99.99%Forma y color:SolidPeso molecular:454.63AZD1208
CAS:<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Fórmula:C21H21N3O2SPureza:97.24% - 99.83%Forma y color:SolidPeso molecular:379.48UBCS039
CAS:<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Fórmula:C16H13N3Pureza:98.31%Forma y color:SolidPeso molecular:247.29Ligustilide
CAS:<p>3-Butylidene-4,5-dihydrophthalide is an effective constituent extracted from Angelica sinensis.</p>Fórmula:C12H14O2Pureza:96.03% - 98.14%Forma y color:Yellow Brown PowderPeso molecular:190.24Pinosylvin
CAS:<p>Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.</p>Fórmula:C14H12O2Pureza:99.89% - 99.91%Forma y color:SolidPeso molecular:212.24Berbamine dihydrochloride
CAS:<p>Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.</p>Fórmula:C37H42Cl2N2O6Pureza:95% - 99.99%Forma y color:SolidPeso molecular:681.65Isosorbide Mononitrate
CAS:<p>Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.</p>Fórmula:C6H9NO6Pureza:98.16%Forma y color:Isosorbide-5-Mononitrate Is A Crystalline Solid It Is Very Flammable And May Be Toxic By IngestionPeso molecular:191.14Entinostat
CAS:<p>Entinostat (MS-275) is an HDAC class I with oral activity. Entinostat has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C21H20N4O3Pureza:98% - 99.74%Forma y color:SolidPeso molecular:376.41CCT128930 hydrochloride
CAS:<p>CCT128930 hydrochloride: Potent AKT inhibitor (IC50=6 nM), 28x selective over PKA, 20x over p70S6K, induces cell cycle arrest & DNA damage.</p>Fórmula:C18H21Cl2N5Pureza:98.55%Forma y color:SolidPeso molecular:378.3Gartanin
CAS:<p>Gartanin enhances androgen receptor degradation and has neuroprotective effects by boosting HO-1, AMPK, SIRT1, and PGC-1α pathways.</p>Fórmula:C23H24O6Pureza:99.64% - 99.85%Forma y color:SolidPeso molecular:396.43PTC-209 hydrobromide
CAS:<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Fórmula:C17H13Br2N5OS·HBrPureza:99.91%Forma y color:SolidPeso molecular:576.1Autogramin-1
CAS:<p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>Fórmula:C23H27N5O5SPureza:97.69% - 99.25%Forma y color:SolidPeso molecular:485.56XL388
CAS:<p>XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.</p>Fórmula:C23H22FN3O4SPureza:99.39% - 99.53%Forma y color:SolidPeso molecular:455.5NSC 185058
CAS:<p>NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.</p>Fórmula:C11H9N3SPureza:99.27%Forma y color:SolidPeso molecular:215.27PF-543 hydrochloride
CAS:<p>PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2</p>Fórmula:C27H32ClNO4SPureza:98.9% - 99.93%Forma y color:SolidPeso molecular:502.1URMC-099
CAS:<p>URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.</p>Fórmula:C27H27N5Pureza:99.32% - 99.98%Forma y color:SolidPeso molecular:421.54Autocamtide-2-related inhibitory peptide
CAS:<p>Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Fórmula:C64H116N22O19Pureza:>99.99%Forma y color:SolidPeso molecular:1497.74PF-06447475
CAS:<p>PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.</p>Fórmula:C17H15N5OPureza:98.61% - 99.62%Forma y color:SolidPeso molecular:305.33Onjisaponin B
CAS:<p>Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-</p>Fórmula:C75H112O35Pureza:99.20% - 99.972%Forma y color:SolidPeso molecular:1573.67A-867744
CAS:<p>A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).</p>Fórmula:C20H19ClN2O3SPureza:95.66%Forma y color:SolidPeso molecular:402.89MRT68921
CAS:<p>MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.</p>Fórmula:C25H34N6OPureza:99.23%Forma y color:SolidPeso molecular:434.58TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Fórmula:C20H12F3N3Pureza:99.55% - 99.94%Forma y color:SolidPeso molecular:351.32PI3Kδ-IN-15
CAS:<p>CAL-101 (Idelalisib) is a selective inhibitor of p110δ; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ.</p>Fórmula:C21H16FN7OPureza:99.61%Forma y color:SolidPeso molecular:401.4Lanatoside C
CAS:<p>Lanatoside C, a cardiac glycoside, treats heart failure and arrhythmia; taken orally or IV.</p>Fórmula:C49H76O20Pureza:98.3% - >99.99%Forma y color:SolidPeso molecular:985.12Spautin-1
CAS:<p>Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Cost-effective and quality-assured.</p>Fórmula:C15H11F2N3Pureza:97.69% - 98.99%Forma y color:SolidPeso molecular:271.26Sofalcone
CAS:<p>Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.</p>Fórmula:C27H30O6Pureza:97.55%Forma y color:SolidPeso molecular:450.52Hesperadin
CAS:<p>Hesperadin(IC50=250 nM) effectively inhibits Aurora B.</p>Fórmula:C29H32N4O3SPureza:98.04% - 99.44%Forma y color:SolidPeso molecular:516.65Nitroprusside disodium dihydrate
CAS:<p>Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.</p>Fórmula:C5H4FeN6Na2O3Pureza:98%Forma y color:Bright RedPeso molecular:297.95UNC1999
CAS:<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Fórmula:C33H43N7O2Pureza:99.19% - >99.99%Forma y color:SolidPeso molecular:569.74Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Fórmula:C51H82O21Pureza:99.51% - 99.63%Forma y color:SolidPeso molecular:1031.18Ivacaftor
CAS:<p>Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,</p>Fórmula:C24H28N2O3Pureza:99% - 99.98%Forma y color:SolidPeso molecular:392.49α-Thujone
CAS:<p>α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.</p>Fórmula:C10H16OPureza:97.02% - 98.41%Forma y color:Less Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996) Colorless Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996)Peso molecular:152.23Biochanin A
CAS:<p>Biochanin A: an isoflavone from red clover with anticancer properties and inhibits FAAH.</p>Fórmula:C16H12O5Pureza:97.1% - 98.97%Forma y color:SolidPeso molecular:284.26Urolithin A
CAS:<p>Urolithin A is a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Cost-effective and quality-assured.</p>Fórmula:C13H8O4Pureza:99.14% - 99.67%Forma y color:SolidPeso molecular:228.2Omipalisib
CAS:<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Forma y color:SolidPeso molecular:505.5
