Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1486 productos de "Autofagia"
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Cediranib
CAS:Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.Fórmula:C25H27FN4O3Pureza:97.21% - 99.94%Forma y color:SolidPeso molecular:450.51Tubastatin A Hydrochloride
CAS:<p>Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM).</p>Fórmula:C20H21N3O2·HClPureza:97.24% - 99.15%Forma y color:SolidPeso molecular:371.86Quizartinib
CAS:Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.Fórmula:C29H32N6O4SPureza:98% - 99.42%Forma y color:SolidPeso molecular:560.67AZD1208
CAS:<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Fórmula:C21H21N3O2SPureza:97.24% - 99.83%Forma y color:SolidPeso molecular:379.48U0126-EtOH
CAS:U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!Fórmula:C18H16N6S2·C2H6OPureza:99.72% - 99.88%Forma y color:SolidPeso molecular:426.6Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Fórmula:C25H34N4O2SPureza:98.89% - >99.99%Forma y color:SolidPeso molecular:454.63Apigenin
CAS:<p>Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants.</p>Fórmula:C15H10O5Pureza:97.64% - 99.66%Forma y color:Yellow Needles From Aqueous Pyridine SolidPeso molecular:270.24MRT68921 dihydrochloride
CAS:MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).Fórmula:C25H36Cl2N6OPureza:98.91% - 99.92%Forma y color:SolidPeso molecular:507.499Ligustilide
CAS:3-Butylidene-4,5-dihydrophthalide is an effective constituent extracted from Angelica sinensis.Fórmula:C12H14O2Pureza:96.03% - 99.97%Forma y color:Yellow Brown PowderPeso molecular:190.24Isosorbide Mononitrate
CAS:Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.Fórmula:C6H9NO6Pureza:98.16%Forma y color:Isosorbide-5-Mononitrate Is A Crystalline Solid It Is Very Flammable And May Be Toxic By IngestionPeso molecular:191.14Berbamine dihydrochloride
CAS:Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.Fórmula:C37H42Cl2N2O6Pureza:95% - 99.99%Forma y color:SolidPeso molecular:681.65Pinosylvin
CAS:Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.Fórmula:C14H12O2Pureza:99.89% - 99.91%Forma y color:SolidPeso molecular:212.24Entinostat
CAS:Entinostat (MS-275) is an HDAC class I with oral activity. Entinostat has antitumor activity. Cost-effective and quality-assured.Fórmula:C21H20N4O3Pureza:98% - 99.74%Forma y color:SolidPeso molecular:376.41CCT128930 hydrochloride
CAS:CCT128930 hydrochloride: Potent AKT inhibitor (IC50=6 nM), 28x selective over PKA, 20x over p70S6K, induces cell cycle arrest & DNA damage.Fórmula:C18H21Cl2N5Pureza:98.55%Forma y color:SolidPeso molecular:378.3Gartanin
CAS:Gartanin enhances androgen receptor degradation and has neuroprotective effects by boosting HO-1, AMPK, SIRT1, and PGC-1α pathways.Fórmula:C23H24O6Pureza:99.64% - 99.85%Forma y color:SolidPeso molecular:396.43Autogramin-1
CAS:Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.Fórmula:C23H27N5O5SPureza:97.69% - 99.25%Forma y color:SolidPeso molecular:485.56PTC-209 hydrobromide
CAS:<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Fórmula:C17H13Br2N5OS·HBrPureza:99.91%Forma y color:SolidPeso molecular:576.1NSC 185058
CAS:NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.Fórmula:C11H9N3SPureza:99.27%Forma y color:SolidPeso molecular:215.27PF-543 hydrochloride
CAS:PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2Fórmula:C27H32ClNO4SPureza:98.9% - 99.93%Forma y color:SolidPeso molecular:502.1XL388
CAS:XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Fórmula:C23H22FN3O4SPureza:99.39% - 99.53%Forma y color:SolidPeso molecular:455.5
