Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1486 productos de "Autofagia"
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Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Fórmula:C24H28N2O3Pureza:99% - 99.98%Forma y color:SolidPeso molecular:392.49Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Forma y color:SolidPeso molecular:505.5Urolithin A
CAS:Urolithin A is a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Cost-effective and quality-assured.Fórmula:C13H8O4Pureza:99.14% - 99.67%Forma y color:SolidPeso molecular:228.2Briciclib
CAS:Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.Fórmula:C19H23O10PSPureza:98% - 99.84%Forma y color:SolidPeso molecular:474.42OSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Fórmula:C21H22N6O3Pureza:97.42%Forma y color:SolidPeso molecular:406.44Nocodazole
CAS:Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.Fórmula:C14H11N3O3SPureza:98% - 99.91%Forma y color:Physical Description White Powder (Ntp 1992)Peso molecular:301.32Atorvastatin hemicalcium trihydrate
CAS:Atorvastatin hemicalcium trihydrate, an oral HMG-CoA reductase inhibitor, lowers blood lipids and inhibits SV-SMC with IC50s: 0.39/2.39 μM.Fórmula:C33H35FN2O5Ca·3H2OForma y color:SolidPeso molecular:632.73Nesolicaftor
CAS:Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Fórmula:C18H18N4O4Pureza:99.79%Forma y color:SolidPeso molecular:354.36Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Fórmula:C18H22BrN5O3Pureza:98.86% - 99.87%Forma y color:SolidPeso molecular:436.3Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Fórmula:C35H28F3N5O2Pureza:98.3% - 99.33%Forma y color:SolidPeso molecular:607.62Tropifexor
CAS:<p>Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.</p>Fórmula:C29H25F4N3O5SPureza:99.3% - 99.85%Forma y color:SolidPeso molecular:603.58Aliskiren hydrochloride
CAS:Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is a selective, orally active, renin inhibitor (IC50: 1.5 nM). Cachexia.Fórmula:C30H54ClN3O6Forma y color:SolidPeso molecular:588.23SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Fórmula:C19H21ClF3N5O2Pureza:99.42% - 99.79%Forma y color:SolidPeso molecular:443.85Crenolanib
CAS:Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).Fórmula:C26H29N5O2Pureza:98.40% - 99.73%Forma y color:SolidPeso molecular:443.54SBI-0206965
CAS:<p>SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.</p>Fórmula:C21H21BrN4O5Pureza:99.13%Forma y color:SolidPeso molecular:489.32AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Fórmula:C17H14N2O3Pureza:98.6% - 99.85%Forma y color:Yellow SolidPeso molecular:294.3ULK-101
CAS:ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.Fórmula:C22H16F4N4OSPureza:97.55% - 99.94%Forma y color:SolidPeso molecular:460.45Lumacaftor
CAS:Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.Fórmula:C24H18F2N2O5Pureza:99.48% - 99.68%Forma y color:SolidPeso molecular:452.41PF-06454589
CAS:PF-06454589 is a potent inhibitor of LRRK2.Fórmula:C14H16N6OPureza:99.06%Forma y color:SolidPeso molecular:284.32AZ304
CAS:AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).Fórmula:C27H25N5O2Pureza:99.82%Forma y color:SolidPeso molecular:451.52
