Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1459 productos de "Autofagia"
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Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Fórmula:C23H28N8OSPureza:99.99%Forma y color:SolidPeso molecular:464.59Regorafenib Hydrochloride
CAS:<p>Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.</p>Fórmula:C21H16Cl2F4N4O3Pureza:99.56%Forma y color:SolidPeso molecular:519.28Aloe emodin
CAS:<p>Aloe emodin (Rhabarberone) is an interferon-inducing agent, for JEV （IC50=1 μg/mL） and EV71（IC50=0.33 μg/mL ）.</p>Fórmula:C15H10O5Pureza:97.00%Forma y color:Orange SolidPeso molecular:270.24GSK343
CAS:GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity againstFórmula:C31H39N7O2Pureza:98% - 99.9%Forma y color:SolidPeso molecular:541.69LYN-1604 dihydrochloride
CAS:LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.Fórmula:C33H45Cl4N3O2Pureza:98.95% - 99.92%Forma y color:SolidPeso molecular:657.54OSU-T315
CAS:<p>OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.</p>Fórmula:C30H30F3N5OPureza:98.69%Forma y color:SolidPeso molecular:533.59Ixazomib
CAS:<p>Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.</p>Fórmula:C14H19BCl2N2O4Pureza:98% - 98.92%Forma y color:SolidPeso molecular:361.03SBE13 Hydrochloride
CAS:SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.Fórmula:C24H28Cl2N2O4Pureza:99.00% - ≥95%Forma y color:SolidPeso molecular:479.4Oxyphenisatin acetate
CAS:<p>Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.</p>Fórmula:C24H19NO5Pureza:98% - 99.35%Forma y color:SolidPeso molecular:401.41Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Fórmula:C25H35ClN4O2SPureza:99.36%Forma y color:SolidPeso molecular:491.09YM-201636
CAS:YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.Fórmula:C25H21N7O3Pureza:93.28% - 98.3%Forma y color:SolidPeso molecular:467.48Doramapimod
CAS:Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Fórmula:C31H37N5O3Pureza:97.14% - 98.80%Forma y color:SolidPeso molecular:527.66Veliparib dihydrochloride
CAS:<p>Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.</p>Fórmula:C13H18Cl2N4OPureza:98% - 99.81%Forma y color:SolidPeso molecular:317.21Ambroxol hydrochloride
CAS:Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract.Fórmula:C13H18Br2N2O·HClPureza:99.70%Forma y color:White To Yellowish Crystalline PowderPeso molecular:414.56CFTR corrector 2
CAS:<p>CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.</p>Fórmula:C27H23FN4O4Pureza:99.66%Forma y color:SolidPeso molecular:486.49ZLN005
CAS:<p>ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.</p>Fórmula:C17H18N2Pureza:98.59% - >99.99%Forma y color:SolidPeso molecular:250.34TWS119
CAS:<p>TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation</p>Fórmula:C18H14N4O2Pureza:98.14% - 99.63%Forma y color:SolidPeso molecular:318.33Rutin hydrate
CAS:<p>Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit.</p>Fórmula:C27H32O17Pureza:97.23%Forma y color:SolidPeso molecular:628.53Liensinine diperchlorate
CAS:<p>Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus.</p>Fórmula:C37H44Cl2N2O14Pureza:99.8% - ≥95%Forma y color:SolidPeso molecular:811.67Bafilomycin A1
CAS:<p>Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible.</p>Fórmula:C35H58O9Pureza:95.87% - 99.36%Forma y color:SolidPeso molecular:622.83
