DUB
Los inhibidores de las deubiquitinasas (DUB) se dirigen a las enzimas que eliminan las moléculas de ubiquitina de las proteínas, regulando así la estabilidad, localización y actividad de las proteínas dentro de la célula. Las deubiquitinasas desempeñan roles esenciales en varios procesos celulares, incluidos la regulación del ciclo celular, la reparación del ADN y las respuestas inmunitarias. La desregulación de la actividad de las DUB está vinculada al cáncer, a los trastornos neurodegenerativos y a las infecciones virales. Los inhibidores de las DUB pueden modular estos procesos, ofreciendo enfoques terapéuticos potenciales para estas condiciones. En CymitQuimica, proporcionamos inhibidores de DUB para apoyar su investigación en homeostasis de proteínas, cáncer y neurobiología.
Se han encontrado 84 productos de "DUB"
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STD1T
CAS:<p>STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.</p>Fórmula:C19H19N3O4S2Pureza:98.77%Forma y color:SolidPeso molecular:417.5GNE-6776
CAS:<p>GNE-6776 is a selective USP7 inhibitor.</p>Fórmula:C20H20N4O2Pureza:96.59% - 98.2%Forma y color:SolidPeso molecular:348.4DUB-IN-1
CAS:<p>DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).</p>Fórmula:C20H11N5OPureza:98.33% - 98.96%Forma y color:SolidPeso molecular:337.33STAMBP-IN-1
CAS:<p>STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after</p>Fórmula:C27H28N4O4SPureza:99.64%Forma y color:SolidPeso molecular:504.6P 22077
CAS:<p>P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.</p>Fórmula:C12H7F2NO3S2Pureza:97.9% - 99.58%Forma y color:SolidPeso molecular:315.32USP25/28 inhibitor AZ1
CAS:<p>USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.</p>Fórmula:C17H16BrF4NO2Pureza:99.79% - 99.79%Forma y color:SolidPeso molecular:422.21XL177A
CAS:<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Fórmula:C48H57ClN8O5Pureza:98.75%Forma y color:SolidPeso molecular:861.47NSC632839
CAS:<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Fórmula:C21H22ClNOPureza:99.74% - 99.88%Forma y color:SolidPeso molecular:339.86SJB2-043
CAS:<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Fórmula:C17H9NO3Pureza:98.44%Forma y color:SolidPeso molecular:275.26IU1-248
CAS:<p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>Fórmula:C20H23N3O2Pureza:99.3%Forma y color:SolidPeso molecular:337.42USP7-IN-8
CAS:<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Fórmula:C21H21N3O2Pureza:99.31%Forma y color:SolidPeso molecular:347.41VLX1570
CAS:<p>VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.</p>Fórmula:C23H17F2N3O6Pureza:98.53% - 99.91%Forma y color:SolidPeso molecular:469.39EOAI3402143
CAS:<p>EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.</p>Fórmula:C25H28Cl2N4O3Pureza:99.6%Forma y color:SolidPeso molecular:503.42P005091
CAS:<p>P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.</p>Fórmula:C12H7Cl2NO3S2Pureza:99.53% - 99.87%Forma y color:SolidPeso molecular:348.22DUB-IN-3
CAS:<p>DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.</p>Fórmula:C16H9N5OPureza:99.34%Forma y color:SolidPeso molecular:287.28ML-323
CAS:<p>ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.</p>Fórmula:C23H24N6Pureza:99.87% - 99.96%Forma y color:SolidPeso molecular:384.48DUB-IN-2
CAS:<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Fórmula:C15H9N5OPureza:98.96%Forma y color:SolidPeso molecular:275.26USP7/USP47 inhibitor
CAS:<p>USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,</p>Fórmula:C18H11Cl2N3O3S3Pureza:98.5% - 98.71%Forma y color:SolidPeso molecular:484.4GNE-6640
CAS:<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Fórmula:C20H18N4OPureza:98.64%Forma y color:SolidPeso molecular:330.38ML364
CAS:<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Fórmula:C24H18F3N3O3S2Pureza:99.35% - >99.99%Forma y color:SolidPeso molecular:517.54
