DUB
Los inhibidores de las deubiquitinasas (DUB) se dirigen a las enzimas que eliminan las moléculas de ubiquitina de las proteínas, regulando así la estabilidad, localización y actividad de las proteínas dentro de la célula. Las deubiquitinasas desempeñan roles esenciales en varios procesos celulares, incluidos la regulación del ciclo celular, la reparación del ADN y las respuestas inmunitarias. La desregulación de la actividad de las DUB está vinculada al cáncer, a los trastornos neurodegenerativos y a las infecciones virales. Los inhibidores de las DUB pueden modular estos procesos, ofreciendo enfoques terapéuticos potenciales para estas condiciones. En CymitQuimica, proporcionamos inhibidores de DUB para apoyar su investigación en homeostasis de proteínas, cáncer y neurobiología.
Se han encontrado 84 productos de "DUB"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
HBX28258
CAS:<p>HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.</p>Fórmula:C26H30ClN3OPureza:98%Forma y color:SolidPeso molecular:435.99MF-095
CAS:<p>MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.</p>Fórmula:C27H31N3O4SForma y color:SolidPeso molecular:493.62XL-188
CAS:<p>XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.</p>Fórmula:C32H42N6O4Forma y color:SolidPeso molecular:574.71Capzimin
CAS:<p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>Fórmula:C30H24N6O2S4Pureza:98.31% - 99.32%Forma y color:SolidPeso molecular:628.81I-138
CAS:<p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>Fórmula:C26H23F3N6OPureza:99.41%Forma y color:SolidPeso molecular:492.5USP28-IN-2
CAS:<p>USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.</p>Fórmula:C23H20Cl2N2O3SForma y color:SolidPeso molecular:475.39GSK2643943A
CAS:<p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>Fórmula:C17H12FN3Pureza:97.09%Forma y color:SolidPeso molecular:277.3SJB3-019A
CAS:<p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>Fórmula:C16H8N2O3Pureza:99.72%Forma y color:SolidPeso molecular:276.25USP30 inhibitor 11
CAS:<p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>Fórmula:C17H16N6O2SPureza:98.84% - 99.59%Forma y color:SolidPeso molecular:368.416RK73
CAS:<p>6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).</p>Fórmula:C13H17N5O2SPureza:99.91%Forma y color:SolidPeso molecular:307.37P22074
CAS:<p>P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.</p>Fórmula:C12H9NO3S2Pureza:>99.99%Forma y color:SolidPeso molecular:279.33USP22-IN-1
CAS:<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Fórmula:C22H18N4Pureza:98.2%Forma y color:SolidPeso molecular:338.41OTUB1/USP8-IN-1
CAS:<p>OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.</p>Fórmula:C22H16ClFN2O4Pureza:98.59%Forma y color:SoildPeso molecular:426.83USP1-IN-3
CAS:<p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.</p>Fórmula:C27H24F3N7OForma y color:SolidPeso molecular:519.52USP1-IN-5
CAS:<p>USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less than</p>Fórmula:C27H23F3N8OForma y color:SolidPeso molecular:532.52USP7-IN-12
CAS:<p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>Fórmula:C29H28ClFN4O2SForma y color:SolidPeso molecular:551.07FT206
CAS:<p>FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].</p>Fórmula:C25H29N5OSForma y color:SolidPeso molecular:447.6USP7-IN-1
CAS:<p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>Fórmula:C23H24ClN3O3Pureza:99.82%Forma y color:SolidPeso molecular:425.91DUB-IN-7
CAS:<p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>Fórmula:C17H19N5OForma y color:SolidPeso molecular:309.37FT671
CAS:<p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>Fórmula:C24H23F4N7O3Pureza:98%Forma y color:SolidPeso molecular:533.48USP7-IN-3
CAS:<p>USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).</p>Fórmula:C29H31F3N6O3Pureza:98%Forma y color:SolidPeso molecular:568.59LDN-91946
CAS:<p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>Fórmula:C15H10N2O4SPureza:97.12%Forma y color:SolidPeso molecular:314.32USP30 inhibitor 18
CAS:<p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>Fórmula:C26H28FN3O4SPureza:99.85%Forma y color:SolidPeso molecular:497.58USP1-IN-6
CAS:<p>USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.</p>Fórmula:C29H27F3N8OForma y color:SolidPeso molecular:560.57CT1113
CAS:<p>CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX</p>Fórmula:C25H29N5O2SForma y color:SolidPeso molecular:463.6USP7-IN-13
CAS:<p>USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].</p>Fórmula:C24H28N4O3Forma y color:SolidPeso molecular:420.5IMP-1710
CAS:<p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>Fórmula:C23H19N5OPureza:99.3%Forma y color:SolidPeso molecular:381.43USP7-IN-10
CAS:<p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>Fórmula:C26H29ClN4O3SForma y color:SolidPeso molecular:513.05FT709
CAS:<p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>Fórmula:C23H22N4O7SForma y color:SolidPeso molecular:498.51FT3967385
<p>FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.</p>Fórmula:C21H19N5O2Forma y color:SolidPeso molecular:373.41USP7-IN-6
CAS:<p>USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).</p>Fórmula:C41H43N7O4SPureza:98%Forma y color:SolidPeso molecular:729.89USP7-797
CAS:<p>USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.</p>Fórmula:C27H28ClN3O3SPureza:95.90%Forma y color:SolidPeso molecular:510.05USP5-IN-1
<p>USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.</p>Fórmula:C19H20ClN3O5SPureza:99.76%Forma y color:SoildPeso molecular:437.9USP15-IN-1
CAS:<p>USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).</p>Fórmula:C22H23N3O3Pureza:99.509% - 99.81%Forma y color:SolidPeso molecular:377.44
