Aurora quinasa
Los inhibidores de las quinasas Aurora se dirigen a las quinasas Aurora, una familia de quinasas de serina/treonina que desempeñan un papel crucial en la regulación de la mitosis. Estas quinasas son esenciales para la correcta alineación, segregación y citocinesis de los cromosomas durante la división celular. La actividad anormal de las quinasas Aurora puede llevar a una proliferación celular descontrolada y al cáncer. Al inhibir las quinasas Aurora, estos compuestos pueden inducir la detención del ciclo celular y la apoptosis en células cancerosas, lo que los convierte en herramientas valiosas en la investigación y terapia del cáncer. En CymitQuimica, ofrecemos una amplia gama de inhibidores de quinasas Aurora de alta calidad para apoyar su investigación en la regulación del ciclo celular, mitosis y oncología.
Se han encontrado 111 productos de "Aurora quinasa"
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PHA-680632
CAS:<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Fórmula:C28H35N7O2Pureza:98.2%Forma y color:SolidPeso molecular:501.62GW779439X
CAS:GW779439X is an inhibitor of CDK.Fórmula:C22H21F3N8Pureza:97.87%Forma y color:SolidPeso molecular:454.45AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Fórmula:C28H21N7OSPureza:98.4% - 99.51%Forma y color:SolidPeso molecular:503.58CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Fórmula:C22H23Cl2N7Pureza:96.2% - 99.81%Forma y color:SolidPeso molecular:456.37ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Fórmula:C21H25N7Pureza:97.63% - ≥95%Forma y color:SolidPeso molecular:375.47Barasertib-HQPA
CAS:<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Fórmula:C26H30FN7O3Pureza:98.43% - 99.29%Forma y color:SolidPeso molecular:507.56MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Fórmula:C22H21ClFN3O3SPureza:99.22%Forma y color:SolidPeso molecular:461.94SCH-1473759 hydrochloride
CAS:SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Fórmula:C20H27ClN8OSPureza:98.29%Forma y color:SolidPeso molecular:463TAK-285
CAS:TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Fórmula:C26H25ClF3N5O3Pureza:99.73%Forma y color:SolidPeso molecular:547.96GW843682X
CAS:GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).Fórmula:C22H18F3N3O4SPureza:99.92%Forma y color:SolidPeso molecular:477.46Aurora kinase inhibitor-10
CAS:Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.Fórmula:C21H19F5N6O4SForma y color:SolidPeso molecular:546.47BI-831266
CAS:BI-831266 is a potent and selective Aurora kinase B inhibitor.Fórmula:C27H38ClN7O2Forma y color:SolidPeso molecular:528.09RET-IN-19
CAS:RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.Fórmula:C28H28N6O4SForma y color:SolidPeso molecular:544.62Aurora Kinases-IN-2
CAS:Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.Fórmula:C22H18ClN5O3Forma y color:SolidPeso molecular:435.86L 888607 Racemate
CAS:L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Fórmula:C19H15ClFNO2SForma y color:SolidPeso molecular:375.84Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Fórmula:C25H22ClFN6O2SPureza:98.45%Forma y color:SolidPeso molecular:525SAR156497
CAS:SAR156497: selective Aurora A/B/C inhibitor; IC50: 0.5 nM (A), 1 nM (B), 3 nM (C); good metabolic stability; anti-tumoral without genetic specificity.Fórmula:C27H24N4O4Forma y color:SolidPeso molecular:468.5HOI-07
CAS:HOI-07 is a specific Aurora B inhibitor.Fórmula:C19H13NO4Forma y color:SolidPeso molecular:319.31OM-137
CAS:OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Fórmula:C13H14N4O3SForma y color:SolidPeso molecular:306.34Aurora Kinases-IN-3
CAS:Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Fórmula:C20H16F3N3O4Forma y color:SolidPeso molecular:419.35
