Aurora quinasa
Los inhibidores de las quinasas Aurora se dirigen a las quinasas Aurora, una familia de quinasas de serina/treonina que desempeñan un papel crucial en la regulación de la mitosis. Estas quinasas son esenciales para la correcta alineación, segregación y citocinesis de los cromosomas durante la división celular. La actividad anormal de las quinasas Aurora puede llevar a una proliferación celular descontrolada y al cáncer. Al inhibir las quinasas Aurora, estos compuestos pueden inducir la detención del ciclo celular y la apoptosis en células cancerosas, lo que los convierte en herramientas valiosas en la investigación y terapia del cáncer. En CymitQuimica, ofrecemos una amplia gama de inhibidores de quinasas Aurora de alta calidad para apoyar su investigación en la regulación del ciclo celular, mitosis y oncología.
Se han encontrado 116 productos para "Aurora quinasa".
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LY3295668
CAS:LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Fórmula:C24H26ClF2N5O2Pureza:99.68%Forma y color:SolidPeso molecular:489.95TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Fórmula:C18H16ClN5Forma y color:SolidPeso molecular:337.81Aurora inhibitor 1
CAS:Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).Fórmula:C23H25N9SPureza:98%Forma y color:SolidPeso molecular:459.57Aurora A inhibitor 1
CAS:Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)Fórmula:C25H28ClF2N5O2Forma y color:SolidPeso molecular:503.97Glycyl H-1152 hydrochloride
CAS:Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Fórmula:C18H26Cl2N4O3SForma y color:SolidPeso molecular:449.39Aurora A inhibitor 4
CAS:Aurora A inhibitor4 (compound C9) is a potent inhibitor of Aurora A, with GI50 values of 4.26 μM in DU 145 cells and 7.08 μM in HT-29 cells.Fórmula:C22H23N5O3Forma y color:SolidPeso molecular:405.45Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Fórmula:C16H20N6OForma y color:SolidPeso molecular:312.37Tripolin B
CAS:Tripolin B is an ATP-competitive inhibitor of Aurora kinases, with IC50 values of 2.5 µM and 6 µM for Aurora A and Aurora B kinases, respectively. However, it exhibits no inhibitory effect within cells.Fórmula:C12H9N3OForma y color:SolidPeso molecular:211.22AJI-214
CAS:AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD).Fórmula:C17H13ClFN5OForma y color:SolidPeso molecular:357.77AJI-100
CAS:AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Fórmula:C17H14FN5OForma y color:SolidPeso molecular:323.32SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Fórmula:C20H26N8OSPureza:98%Forma y color:SolidPeso molecular:426.54BRD-7880
CAS:BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.Fórmula:C32H38N4O7Forma y color:SolidPeso molecular:590.676K465
CAS:6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.Fórmula:C26H33ClFN9OPureza:99.78%Forma y color:SolidPeso molecular:542.05BET/Aurora kinase-IN-1
CAS:BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.Fórmula:C25H30FN7OForma y color:SolidPeso molecular:463.55Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Fórmula:C29H33ClN4O3SForma y color:SolidPeso molecular:553.12Aurora B inhibitor 1
CAS:Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Fórmula:C25H26ClF2N7O2Pureza:98.37%Forma y color:SolidPeso molecular:529.97
