Receptor sigma
Los receptores sigma son sitios de unión únicos que, a diferencia de los GPCR tradicionales, no encajan en las categorías clásicas de proteínas receptoras. Están involucrados en la modulación de los sistemas de neurotransmisores y se han implicado en varios trastornos neurológicos y psiquiátricos. Los receptores sigma también están asociados con la supervivencia celular, y sus ligandos se están explorando para aplicaciones terapéuticas en neuroprotección, cáncer y manejo del dolor. En CymitQuimica, ofrecemos una selección de moduladores de receptores sigma de alta calidad para apoyar su investigación en neurociencia, oncología y biología de receptores.
Se han encontrado 46 productos de "Receptor sigma"
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Siramesine hydrochloride
CAS:<p>Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit</p>Fórmula:C30H32ClFN2OPureza:99.72% - >99.99%Forma y color:SolidPeso molecular:491.04PRE-084 hydrochloride
CAS:<p>PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).</p>Fórmula:C19H28ClNO3Pureza:99.54%Forma y color:SolidPeso molecular:353.88BD 1008 dihydrobromide
CAS:<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Fórmula:C15H24Br2Cl2N2Pureza:97.81%Forma y color:SolidPeso molecular:463.08Dimemorfan phosphate
CAS:<p>Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.</p>Fórmula:C18H25N·H3O4PPureza:99.65%Forma y color:SolidPeso molecular:353.4Blarcamesine hydrochloride
CAS:<p>Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).</p>Fórmula:C19H24ClNOPureza:99.57% - 99.9%Forma y color:SolidPeso molecular:317.85BD-1047 dihydrobromide
CAS:<p>BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy</p>Fórmula:C13H22Br2Cl2N2Pureza:98.13% - 99.39%Forma y color:SolidPeso molecular:437.04Blarcamesine
CAS:<p>Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.</p>Fórmula:C19H23NOPureza:99.87%Forma y color:SolidPeso molecular:281.39Ditolylguanidine
CAS:<p>Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).</p>Fórmula:C15H17N3Pureza:98.42%Forma y color:White To Pinkish Solid PowderPeso molecular:239.32S1RA hydrochloride
CAS:<p>S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki ></p>Fórmula:C20H24ClN3O2Pureza:98% - 99.84%Forma y color:SolidPeso molecular:373.87KB-5492 free base
CAS:<p>KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.</p>Fórmula:C23H30N2O6Pureza:97.10% - 97.94%Forma y color:SolidPeso molecular:430.49Opipramol
CAS:<p>Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.</p>Fórmula:C23H29N3OPureza:99.84% - 99.98%Forma y color:SolidPeso molecular:363.5S1RA
CAS:<p>S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2</p>Fórmula:C20H23N3O2Pureza:99.45%Forma y color:SolidPeso molecular:337.42PD 144418
CAS:<p>PD 144418 displays potential antipsychotic activity.</p>Fórmula:C18H22N2OPureza:98%Forma y color:SolidPeso molecular:282.38Sigma-LIGAND-1
CAS:<p>Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.</p>Fórmula:C27H33NO4Pureza:99.89%Forma y color:SolidPeso molecular:435.56DuP 734
CAS:<p>DuP 734 is a potent and selective sigma receptor antagonist, functioning as a ligand for both sigma and 5-HT2 receptors, and exhibiting weak affinity towards D2 receptors. It possesses potential antipsychotic activity, potentially devoid of the motor side effects commonly observed with neuroleptics[1][2][3].</p>Fórmula:C17H23BrFNOForma y color:SolidPeso molecular:356.279NE-100 hydrochloride
CAS:<p>NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.</p>Fórmula:C23H34ClNO2Pureza:99.76%Forma y color:SolidPeso molecular:391.98Sigma-1 receptor antagonist 3
CAS:<p>Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).</p>Fórmula:C19H23ClFN3OPureza:99.95%Forma y color:SolidPeso molecular:363.86WLB-89462
CAS:<p>WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-</p>Fórmula:C21H29N5O3Pureza:98%Forma y color:SolidPeso molecular:399.49Sigma-1 receptor antagonist 2
CAS:<p>Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).</p>Fórmula:C20H26ClN3O2Pureza:99.6%Forma y color:SolidPeso molecular:375.89S1R agonist 1 hydrochloride
CAS:<p>S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated</p>Fórmula:C20H26ClNOPureza:98%Forma y color:SolidPeso molecular:331.88
