Receptor sigma
Los receptores sigma son sitios de unión únicos que, a diferencia de los GPCR tradicionales, no encajan en las categorías clásicas de proteínas receptoras. Están involucrados en la modulación de los sistemas de neurotransmisores y se han implicado en varios trastornos neurológicos y psiquiátricos. Los receptores sigma también están asociados con la supervivencia celular, y sus ligandos se están explorando para aplicaciones terapéuticas en neuroprotección, cáncer y manejo del dolor. En CymitQuimica, ofrecemos una selección de moduladores de receptores sigma de alta calidad para apoyar su investigación en neurociencia, oncología y biología de receptores.
Se han encontrado 48 productos para "Receptor sigma".
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Siramesine hydrochloride
CAS:Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFórmula:C30H32ClFN2OPureza:99.67% - 99.75%Forma y color:SolidPeso molecular:491.04Ref: TM-T1885
1mg57,00€2mg84,00€5mg105,00€1mL*10mM (DMSO)114,00€10mg170,00€25mg334,00€50mg500,00€100mg705,00€PRE-084 hydrochloride
CAS:PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).Fórmula:C19H28ClNO3Pureza:99.54%Forma y color:White SolidPeso molecular:353.88Ref: TM-T3198L
5mg42,00€10mg62,00€1mL*10mM (DMSO)69,00€25mg114,00€50mg197,00€100mg350,00€200mg535,00€BD 1008 dihydrobromide
CAS:BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.Fórmula:C15H24Br2Cl2N2Pureza:97.81%Forma y color:SolidPeso molecular:463.08Dimemorfan phosphate
CAS:Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.Fórmula:C18H25N·H3O4PPureza:99.65%Forma y color:SolidPeso molecular:353.4Blarcamesine hydrochloride
CAS:Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).Fórmula:C19H24ClNOPureza:99.57% - 99.9%Forma y color:White SolidPeso molecular:317.85Ref: TM-T4111
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg197,00€50mg340,00€100mg557,00€200mg790,00€Cutamesine dihydrochloride
CAS:Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.Fórmula:C23H32N2O2·2HClPureza:99.96%Forma y color:SolidPeso molecular:441.43Ref: TM-T3597
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg167,00€50mg260,00€100mg401,00€200mg580,00€σ1 Receptor antagonist-1
CAS:σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.Fórmula:C21H23NOSPureza:99.8%Forma y color:SolidPeso molecular:337.48Ditolylguanidine
CAS:Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).Fórmula:C15H17N3Pureza:98.42%Forma y color:White To Pinkish Solid PowderPeso molecular:239.32BD-1047 dihydrobromide
CAS:BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacyFórmula:C13H22Br2Cl2N2Pureza:98.13% - 99.39%Forma y color:White SolidPeso molecular:437.04Ref: TM-T1740
1mg34,00€2mg46,00€5mg70,00€1mL*10mM (DMSO)71,00€10mg90,00€25mg159,00€50mg275,00€100mg465,00€S1RA hydrochloride
CAS:S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki >Fórmula:C20H24ClN3O2Pureza:98% - 99.84%Forma y color:SolidPeso molecular:373.87Ref: TM-T4229
1mg35,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg105,00€25mg205,00€50mg334,00€100mg492,00€500mg973,00€BD1063 dhydrochloride
CAS:BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).Fórmula:C13H20Cl4N2Pureza:99.52% - ≥95%Forma y color:SolidPeso molecular:346.12Ref: TM-T7488
2mg46,00€5mg69,00€10mg95,00€25mg177,00€50mg321,00€100mg472,00€200mg665,00€500mg1.018,00€KB-5492 free base
CAS:KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.Fórmula:C23H30N2O6Pureza:97.10% - 97.94%Forma y color:SolidPeso molecular:430.49Ref: TM-T62396
2mg39,00€5mg58,00€1mL*10mM (DMSO)64,00€10mg82,00€25mg119,00€50mg168,00€100mg249,00€500mg613,00€S1RA
CAS:S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2Fórmula:C20H23N3O2Pureza:99.45%Forma y color:SolidPeso molecular:337.42Opipramol
CAS:Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.Fórmula:C23H29N3OPureza:99.84% - 99.98%Forma y color:Yellow SolidPeso molecular:363.5Sigma-LIGAND-1
CAS:Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.Fórmula:C27H33NO4Pureza:99.89%Forma y color:SolidPeso molecular:435.56Ref: TM-T13510
1mg46,00€5mg99,00€1mL*10mM (DMSO)113,00€10mg147,00€25mg222,00€50mg299,00€100mg411,00€200mg553,00€DuP 734
CAS:DuP 734 is a potent and selective sigma receptor antagonist, functioning as a ligand for both sigma and 5-HT2 receptors, and exhibiting weak affinity towards D2 receptors. It possesses potential antipsychotic activity, potentially devoid of the motor side effects commonly observed with neuroleptics[1][2][3].Fórmula:C17H23BrFNOForma y color:SolidPeso molecular:356.279PD 144418
CAS:PD 144418 displays potential antipsychotic activity.Fórmula:C18H22N2OPureza:98%Forma y color:SolidPeso molecular:282.38NE-100 hydrochloride
CAS:NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.Fórmula:C23H34ClNO2Pureza:99.76%Forma y color:White SolidPeso molecular:391.98Ref: TM-T20797
1mg43,00€2mg54,00€5mg87,00€10mg130,00€25mg210,00€50mg313,00€100mg465,00€200mg662,00€500mg982,00€Sigma-1 receptor antagonist 1
CAS:Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.Fórmula:C19H23Cl2N3OPureza:99.92%Forma y color:SolidPeso molecular:380.31S1R agonist 1 hydrochloride
CAS:S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFórmula:C20H26ClNOPureza:98%Forma y color:SolidPeso molecular:331.88
