Receptor sigma
Los receptores sigma son sitios de unión únicos que, a diferencia de los GPCR tradicionales, no encajan en las categorías clásicas de proteínas receptoras. Están involucrados en la modulación de los sistemas de neurotransmisores y se han implicado en varios trastornos neurológicos y psiquiátricos. Los receptores sigma también están asociados con la supervivencia celular, y sus ligandos se están explorando para aplicaciones terapéuticas en neuroprotección, cáncer y manejo del dolor. En CymitQuimica, ofrecemos una selección de moduladores de receptores sigma de alta calidad para apoyar su investigación en neurociencia, oncología y biología de receptores.
Se han encontrado 48 productos para "Receptor sigma".
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Sigma-1 receptor antagonist 2
CAS:Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).Fórmula:C20H26ClN3O2Pureza:99.6%Forma y color:SolidPeso molecular:375.89Ref: TM-T12911
1mg46,00€5mg96,00€1mL*10mM (DMSO)105,00€10mg161,00€25mg261,00€50mg371,00€100mg504,00€200mg675,00€WLB-89462
CAS:WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-Fórmula:C21H29N5O3Pureza:98%Forma y color:SolidPeso molecular:399.49Sigma-1 receptor antagonist 3
CAS:Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Fórmula:C19H23ClFN3OPureza:99.95%Forma y color:White SolidPeso molecular:363.86Sigma-2 Radioligand 2
CAS:Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).Fórmula:C23H28FN3O3Forma y color:SolidPeso molecular:413.49Opipramol dihydrochloride
CAS:Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).Fórmula:C23H31Cl2N3OForma y color:SolidPeso molecular:436.418UMB24
CAS:UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.Fórmula:C17H21N3Forma y color:SolidPeso molecular:267.37BD-1047
CAS:BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.Fórmula:C13H20Cl2N2Forma y color:SolidPeso molecular:275.217Sigma-1 receptor antagonist 6
CAS:Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.Fórmula:C32H34N6Forma y color:SolidPeso molecular:502.65
