Receptor de opioides
Los receptores opioides son un grupo de receptores acoplados a proteínas G que median los efectos de los opioides endógenos y exógenos. Estos receptores desempeñan un papel central en la modulación del dolor, la regulación del estado de ánimo y los comportamientos adictivos. Los agonistas y antagonistas de los receptores opioides se utilizan ampliamente en el manejo del dolor y el tratamiento de adicciones, así como en la investigación de trastornos neurológicos y psiquiátricos. En CymitQuimica, ofrecemos una selección integral de moduladores de receptores opioides de alta calidad para apoyar su investigación en neurobiología, manejo del dolor y terapia de adicciones.
Se han encontrado 310 productos de "Receptor de opioides"
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KOR agonist 5
KOR agonist 5 (Compound 10a) is both a KOR/MOR modulator, exhibiting agonistic effects on KOR and antagonistic effects on MOR. It effectively blocks morphine-induced antinociception and gastrointestinal motility inhibition. KOR agonist 5 is applicable in research related to substance use disorder (SUD).Fórmula:C38H38N2O5Forma y color:SolidPeso molecular:602.72[DAla2, DArg6] Dynorphin A, (1-13) (porcine)
CAS:'[DAla2, DArg6] Dynorphin A (1-13) porcine is a potent opioid peptide resistant to enzymatic degradation.'Fórmula:C76H128N24O15Forma y color:SolidPeso molecular:1617.98Naldemedine
CAS:Naldemedine (S 297995), developed by Shionogi, is a drug for opioid side effects like constipation. It's well tolerated with minor GI issues.Fórmula:C32H34N4O6Forma y color:SolidPeso molecular:570.64Dafphedyn
CAS:Dafphedyn (DAFPHEDYN), a potent endorphin 1-13 analog, induces diuresis and analgesia in rats via IV.Fórmula:C76H124F5N25O14Forma y color:SolidPeso molecular:1706.95LY255582
CAS:<p>LY255582 is a selective centrally active opioid receptor antagonist with high affinity for mu, delta and kappa receptors with Ki of 0.4 nM, 5.2, 2.0 nM,</p>Fórmula:C22H35NO2Pureza:98%Forma y color:SolidPeso molecular:345.52AP-238
CAS:<p>AP-238 is a novel synthetic opioid (NSO) that acts as an agonist for the μ-opioid receptor (MOR), with an EC50 of 248 nM. Additionally, AP-238 exhibits analgesic properties.</p>Fórmula:C18H26N2OForma y color:SolidPeso molecular:286.41[(pF)Phe4]Nociceptin(1-13)NH2 acetate
<p>[(pF)Phe4]Nociceptin(1-13)NH2 acetate is a selective agonist of NOP receptor with a pKi of 10.68 and a pEC50 of 9.31.</p>Fórmula:C63H103FN22O17Pureza:98.03%Forma y color:SolidPeso molecular:1459.63HINT1-IN-1
<p>HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).</p>Fórmula:C23H24N8O5Forma y color:SolidPeso molecular:492.49[Arg14,Lys15]Nociceptin
CAS:Potent NOP agonist (EC50 = 1 nM), >875x selective vs opioid receptors; outperforms nociceptin in vivo, increases pain perception, reduces movement.Fórmula:C82H137N31O22Pureza:98%Forma y color:SolidPeso molecular:1909.18KOR agonist 4
<p>KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.</p>Fórmula:C21H25N3Forma y color:SolidPeso molecular:319.44β-Endorphin, equine TFA
β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3Fórmula:C156H249F3N42O46SForma y color:SolidPeso molecular:3537.96N-Desmethyl Loperamide
CAS:N-Desmethyl Loperamide is the major metabolite of loperamide. It is also used as the precusor for radiolabelled loperamide.Fórmula:C28H31ClN2O2Forma y color:SolidPeso molecular:463.01β-Endorphin, equine
CAS:<p>Endorphin Beta is A substance produced in the brain, especially in the pituitary gland, Endorphin Beta blocks the sensation of pain.</p>Fórmula:C154H248N42O44SPureza:98%Forma y color:SolidPeso molecular:3423.94Akuammicine
CAS:<p>Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.</p>Fórmula:C20H22N2O2Forma y color:SolidPeso molecular:322.408Valorphin
CAS:Valorphin (Valorphin TFAsalt) has opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM.Fórmula:C44H61N9O11Pureza:98%Forma y color:SolidPeso molecular:892.01(S,S)-J-113397
CAS:(S,S)-J-113397 is an isomer of J-113397 . J-113397 is an Opioid Receptor antagonist [1] .Fórmula:C24H37N3O2Forma y color:SolidPeso molecular:399.57[(pF)Phe4]Nociceptin(1-13)NH2
CAS:<p>Potent, selective OP4 agonist; pKi=10.68, pEC50=9.80. >8000x selectivity vs other opioid receptors; long-lasting in vivo effects.</p>Fórmula:C61H99FN22O15Pureza:98%Forma y color:SolidPeso molecular:1399.6Frakefamide TFA
<p>Frakefamide TFA: potent, peripherally active μ-opioid agonist; doesn't cross blood-brain barrier.</p>Fórmula:C32H35F4N5O7Forma y color:SolidPeso molecular:677.64AH 7959
CAS:AH 7959 is an orally active N-substituted cyclohexylmethylbenzamide compound that exhibits analgesic properties. In mice, the ED50 for oral and subcutaneous administration of AH 7959 exceeds 100 mg/kg.Fórmula:C19H26Cl2N2OForma y color:SolidPeso molecular:369.334-Hydroxy-1-(2-phenylethyl)piperidine
CAS:4-Hydroxy-1-(2-phenylethyl)piperidine is a synthetic ligand for muscarinic acetylcholine receptors (mAChR) or non-opioid intracellular sigma-1 receptors (σ1 receptors). It serves as a metabolite of the opioid compounds furanylfentanyl and 4-fluoroisobutyryl fentanyl (FIBF).Fórmula:C13H19NOForma y color:SolidPeso molecular:205.3
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