GPCR19
GPCR19, también conocido como GPR19, es un miembro de la familia de los receptores acoplados a proteínas G, cuyos roles aún están siendo elucidados en varios procesos fisiológicos. Aunque menos caracterizado que otros GPCR, el GPCR19 es de interés en investigaciones centradas en descubrir nuevos objetivos terapéuticos para enfermedades metabólicas, cáncer y trastornos neurológicos. En CymitQuimica, ofrecemos una selección de herramientas de investigación y reactivos para apoyar sus investigaciones sobre las funciones y las posibles aplicaciones terapéuticas del GPCR19.
Se han encontrado 40 productos para "GPCR19".
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Hyodeoxycholic acid
CAS:Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.Fórmula:C24H40O4Pureza:97.29% - 98.82%Forma y color:SolidPeso molecular:392.572Ursodeoxycholic acid
CAS:Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!Fórmula:C24H40O4Pureza:99.48% - ≥95%Forma y color:White SolidPeso molecular:392.572Deoxycholic acid
CAS:Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate.Fórmula:C24H40O4Pureza:99.84% - 99.95%Forma y color:SolidPeso molecular:392.572TGR5 agonist 1
Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].Fórmula:C28H48NNaO6SForma y color:SolidPeso molecular:549.74LIFR/GPBAR1 modulator 1
LIFR/GPBAR1 modulator 1 is an orally active, potent GPBAR1 agonist (EC50= 0.2 μM) and LIFR inhibitor (IC50= 7.9 μM). It enhances the expression of leukemia inhibitory factor (LIF)-mediated LIFR and GPBAR1 mRNA, while significantly reducing the expression of fibrosis markers (COL1A1, ASMA, and TGFβ), decreasing TIMP1 levels, and increasing MMP9 expression. LIFR/GPBAR1 modulator 1 is applicable for research into human fibrotic diseases.GPBAR-A
CAS:GPBAR-A is a synthetic small-molecule agonist of GPBAR1, also known as TGR5, that activates this G protein–coupled bile acid receptor involved in energy homeostasis, glucose metabolism, and immune regulation, GPBAR-A is extensively studied for its therapeutic potential in metabolic disorders such as type 2 diabetes, obesity, and inflammation-related diseases.Fórmula:C23H15F7N2O2Pureza:99.99%Forma y color:White SolidPeso molecular:484.37TGR5 agonist 4
TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].Fórmula:C24H38F2O5Forma y color:SolidPeso molecular:444.55TGR5 agonist 8
TGR5 agonist 8 (Compound 7i) is a TGR5 activator with an EC₅₀ of 571 nM. It significantly reduces blood glucose levels and food intake in mice with acute diabetes and suppresses appetite over a longer period. TGR5 agonist 8 is applicable for research in diabetes and obesity.5-HT7R antagonist 1 free base
CAS:5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.Fórmula:C14H17ClN4Forma y color:SolidPeso molecular:276.77PEN (human)
CAS:PEN (human) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Fórmula:C97H159N27O32Pureza:98%Forma y color:SolidPeso molecular:2215.49PEN (rat)
CAS:PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Fórmula:C102H169N27O33Pureza:98%Forma y color:SolidPeso molecular:2301.62TGR5 agonist 2
TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].Fórmula:C29H50NNaO6SForma y color:SolidPeso molecular:563.77TGR5 agonist 6
CAS:Compound 22b, also known as TGR5 agonist 6, is a non-systemic, intestine-targeted TGR5 agonist that demonstrates significant and sustained blood glucose-lowering effects with an acceptable safety profile.Fórmula:C42H48Cl2N6O6Forma y color:SolidPeso molecular:803.77TGR5 agonist 7
TGR5 agonist 7 (Compound 22-Na) is an intestine-restricted, orally active agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 of less than 1 μM. In mouse models, it demonstrates blood glucose-lowering effects, making it useful for diabetes research.Fórmula:C37H59N2NaO9SForma y color:SolidPeso molecular:730.93Neuromedin S (human)
CAS:Neuromedin S (human) is a 33-amino acid neuropeptide identified as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1, acting onForma y color:SolidTriamterene
CAS:Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Fórmula:C12H11N7Pureza:99.77%Forma y color:Yellow SolidPeso molecular:253.2626Triamterene (Standard)
CAS:Triamterene (Standard) is the standard substance of Triamterene, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Fórmula:C12H11N7Forma y color:SolidPeso molecular:253.2626BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Fórmula:C25H44O3Pureza:99.95%Forma y color:SolidPeso molecular:392.6151PEN (human) aceate
PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.Fórmula:C99H163N27O34Pureza:95.98%Forma y color:SolidPeso molecular:2275.51Deoxycholic acid sodium salt
CAS:Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates BAT thermogenic activity.Fórmula:C24H39NaO4Pureza:97.88% - 99.84%Forma y color:SolidPeso molecular:414.5538
