GRK
Las quinasas de receptores acoplados a proteínas G (GRK) son una familia de enzimas que fosforilan GPCR activados, lo que lleva a la desensibilización de los receptores y a la regulación de la señalización de los receptores. Las GRK desempeñan un papel crucial en el control de la intensidad y la duración de la señalización de los GPCR, lo que las hace importantes en la regulación de varios procesos fisiológicos, incluida la función cardiovascular, la respuesta inmunitaria y la neurotransmisión. Los inhibidores y activadores de GRK se estudian por su potencial en aplicaciones terapéuticas en insuficiencia cardíaca, cáncer y trastornos neurológicos. En CymitQuimica, ofrecemos una gama de moduladores de GRK de alta calidad para apoyar su investigación en transducción de señales, regulación de receptores y desarrollo terapéutico.
Se han encontrado 33 productos de "GRK"
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CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:99.01% - 99.04%Forma y color:SolidPeso molecular:466.46Corazonin
CAS:Corazonin, a neuropeptide in insects, regulates caste identity and behavior, mainly in workers/foragers.Fórmula:C62H83N17O19Forma y color:SolidPeso molecular:1370.42GRK2-IN-1 hydrochloride (2055990-90-2 free base)
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Fórmula:C24H26ClFN4O4Pureza:98%Forma y color:SolidPeso molecular:488.94Crustacean Cardioactive Peptide (CCAP)
CAS:Crustacean Cardioactive Peptide (CCAP) is a conserved modified cyclic nonapeptide primary structure of PFCNAFTGC-NH2, a disulfide bridge between Cys3 and Cys9.Fórmula:C42H58N10O12S2Pureza:95.40%Forma y color:SolidPeso molecular:959.1CCG258208 hydrochloride
<p>GRKs-IN-1 HCl (14as) strongly inhibits GRK2 (IC50=130nM) & GRK5 (IC50=7.1μM), is a paroxetine derivative with 100x cardiac boost.</p>Forma y color:SolidGRL018-21
GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1].Forma y color:Odour SolidGRK-IN-1
CAS:<p>4-Amino-5-(bromomethyl)-2-methylpyrimidine used in vitamin B1 analogs and esters synthesis.</p>Fórmula:C6H10Br3N3Forma y color:SolidPeso molecular:363.879GRK2i
CAS:GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.Fórmula:C153H256N50O41SPureza:98%Forma y color:SolidPeso molecular:3484.08GSK270822A
CAS:GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.Fórmula:C24H20N4O2Pureza:98.64% - 99.78%Forma y color:SolidPeso molecular:396.44Ref: TM-T27467
1mg133,00€5mg314,00€10mg416,00€25mg632,00€50mg847,00€100mg1.134,00€200mg1.513,00€1mL*10mM (DMSO)323,00€GRL093-22
GRL093-22 is an effective and selective inhibitor of G protein-coupled receptor kinases (GRK), with IC50 values of 60 nM for GRK5 and 40 nM for GRK6. It shows potential for research in heart failure and multiple myeloma.Fórmula:C33H29FN6O3Forma y color:SolidPeso molecular:576.62Endothelin-3, human, mouse, rabbit, rat
CAS:Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor.Fórmula:C121H168N26O33S4Pureza:98%Forma y color:SolidPeso molecular:2643.04GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Fórmula:C19H16FN5O2Pureza:98.38% - 98.98%Forma y color:SolidPeso molecular:365.36Ref: TM-T3513
1mg39,00€2mg50,00€5mg70,00€10mg94,00€25mg161,00€50mg290,00€100mg538,00€500mg1.161,00€1mL*10mM (DMSO)62,00€Takeda103A
CAS:Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.Fórmula:C24H23F2N7OPureza:97.17%Forma y color:SolidPeso molecular:463.48Ref: TM-T24850
1mg85,00€2mg105,00€5mg164,00€10mg258,00€25mg424,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)187,00€CCG215022
CAS:CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.Fórmula:C26H22FN7O3Pureza:97.63% - 99.69%Forma y color:SolidPeso molecular:499.5Ref: TM-T3498
1mg59,00€5mg120,00€10mg188,00€25mg416,00€50mg692,00€100mg1.093,00€1mL*10mM (DMSO)134,00€1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
CAS:<p>1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.</p>Fórmula:C13H13NO5Pureza:99.55%Forma y color:SolidPeso molecular:263.25GRK6-IN-2
CAS:<p>GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.</p>Fórmula:C21H21FN6Pureza:98.94%Forma y color:SolidPeso molecular:376.43KR-39038
CAS:KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.Fórmula:C24H32ClFN6OForma y color:SolidPeso molecular:475.00GSK317354A
CAS:GSK317354A is a GRK2 inhibitor.Fórmula:C25H18F4N6OForma y color:SolidPeso molecular:494.44CCG-273220
CAS:CCG-273220 covalently inhibits GRK5 at Cys474 with 220 nM IC50; more selective over GRK2.Fórmula:C26H24ClFN4O3Forma y color:SolidPeso molecular:494.95GSK466317A
CAS:GSK466317A is a GRK2 inhibitor.Fórmula:C21H16ClF3N4O2Pureza:98%Forma y color:SolidPeso molecular:448.83
![1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT8913.webp&w=3840&q=75)
