Receptor de cannabinoides
Los receptores cannabinoides son GPCR que median los efectos de los cannabinoides endógenos (endocannabinoides) y los fitocannabinoides, como los encontrados en el cannabis. Los dos tipos principales de receptores cannabinoides, CB1 y CB2, están involucrados en la regulación de una amplia gama de procesos fisiológicos, incluida la percepción del dolor, el apetito, el estado de ánimo y la función inmunitaria. Los moduladores de los receptores cannabinoides tienen potencial terapéutico en el tratamiento de afecciones como el dolor crónico, la epilepsia y la esclerosis múltiple. En CymitQuimica, ofrecemos una amplia gama de moduladores de receptores cannabinoides de alta calidad para apoyar su investigación en neurofarmacología, manejo del dolor e inmunología.
Se han encontrado 217 productos de "Receptor de cannabinoides"
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AM841
CAS:AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor.Fórmula:C26H39NO3SPureza:98%Forma y color:SolidPeso molecular:445.66Prostaglandin E2-1-glyceryl ester
CAS:Prostaglandin E2-1-glyceryl ester, a member of the Prostaglandin Glycerol Ester family, serves as an endocannabinoid ligand targeting the CB1 receptor. This compound triggers a swift and transient surge in intracellular free calcium levels [1] [2].Fórmula:C23H38O7Forma y color:SolidPeso molecular:426.55PSB-SB1202
CAS:PSB-SB1202 (Compound 21a), a phenyl coumarin compound, acts as a CB1/CB2 agonist. It demonstrates EC50 values of 56 and 14 nM and K i values of 32 and 49 nM for CB1 and CB2 receptors, respectively [1].Fórmula:C23H26O4Forma y color:SolidPeso molecular:366.45CB2R-IN-1
CAS:CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM).Fórmula:C23H27F3N4O6S3Pureza:98%Forma y color:SolidPeso molecular:608.67CB-25
CAS:CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cellsFórmula:C25H41NO3Pureza:98%Forma y color:SolidPeso molecular:403.6CB-52
CAS:CB-52 acts as a neutral antagonist and ligand for the CB2 cannabinoid receptor [1].Fórmula:C26H43NO3Forma y color:SolidPeso molecular:417.62OMDM-5
CAS:OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Fórmula:C26H44N2O3Pureza:99.73%Forma y color:SolidPeso molecular:432.64Ref: TM-T12306
1mg93,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)210,00€O-Arachidonoyl glycidol
CAS:O-Arachidonoyl glycidol (compound 1), a 2-arachidonoylglycerol (2-AG) analog, effectively inhibits the hydrolysis of cytosolic 2-oleoylglycerol (2-OG) with an IC50 value of 4.5 µM, and also blocks 2-OG and anandamide hydrolysis in membrane fractions with IC50 values of 19 µM and 12 µM, respectively [1].Fórmula:C23H36O3Forma y color:SolidPeso molecular:360.53GSK-554418A
CAS:GSK-554418A, a novel azaindole CB(2) agonists, is used for the treatment of chronic pain. It is efficacious in the acute model and the chronic joint pain model.Fórmula:C19H19ClN4O2Forma y color:SolidPeso molecular:370.83CAY10508
CAS:CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 µM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.Fórmula:C21H14Br2N2O2Forma y color:SolidPeso molecular:486.2GP 1a
CAS:GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.
Fórmula:C23H22Cl2N4OPureza:99.79%Forma y color:SolidPeso molecular:441.35GW 833972A
CAS:GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.
Fórmula:C18H14Cl2F3N5OPureza:99.93%Forma y color:SoildPeso molecular:444.24Bzo-poxizid
CAS:Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.Fórmula:C20H21N3O2Forma y color:SolidPeso molecular:335.40BAY 38-7271
CAS:BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).Fórmula:C20H21F3O5SPureza:98%Forma y color:SolidPeso molecular:430.44AM8936
AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.Fórmula:C25H33NO3Forma y color:SolidPeso molecular:395.53CBR Agonist-2
CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.Fórmula:C27H27FN4OForma y color:SolidPeso molecular:442.53PSB-KK1415
CAS:PSB-KK1415 is a selective agonist for the human orphan G protein-coupled receptor GPR18, with an EC50 of 19.1 nM.Fórmula:C24H23ClN6O2Peso molecular:462.93Cannabigerovarin
CAS:Cannabigerovarin (CBGV) is a compound categorized as a phytocannabinoid.Fórmula:C19H28O2Peso molecular:288.42Ac-Atovaquone
CAS:Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.Fórmula:C24H21ClO4Forma y color:SolidPeso molecular:408.87CBR Agonist-1
CBR Agonist-1 targets CB1R and CB2R with Ki of 0.18 μM and 1.22 μM, useful for studying cannabinoid-related diseases.Fórmula:C27H27FN4OForma y color:SolidPeso molecular:442.53
