Receptor de cannabinoides
Los receptores cannabinoides son GPCR que median los efectos de los cannabinoides endógenos (endocannabinoides) y los fitocannabinoides, como los encontrados en el cannabis. Los dos tipos principales de receptores cannabinoides, CB1 y CB2, están involucrados en la regulación de una amplia gama de procesos fisiológicos, incluida la percepción del dolor, el apetito, el estado de ánimo y la función inmunitaria. Los moduladores de los receptores cannabinoides tienen potencial terapéutico en el tratamiento de afecciones como el dolor crónico, la epilepsia y la esclerosis múltiple. En CymitQuimica, ofrecemos una amplia gama de moduladores de receptores cannabinoides de alta calidad para apoyar su investigación en neurofarmacología, manejo del dolor e inmunología.
Se han encontrado 217 productos de "Receptor de cannabinoides"
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URB447
CAS:URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].Fórmula:C25H21ClN2OForma y color:SolidPeso molecular:400.9Tedalinab
CAS:Tedalinab is an effective and selective cannabinoid receptor 2 agonist.Fórmula:C19H21F2N3OPureza:98%Forma y color:SolidPeso molecular:345.39GW405833 hydrochloride
CAS:GW405833 hydrochloride, a potent and selective agonist of the cannabinoid-2 (CB2) receptor (EC 50 = 0.65 nM; maximum inhibition = 44.6%), exhibits significant antihyperalgesic effects in various rodent pain models [1] [2] [3].Fórmula:C23H25Cl3N2O3Forma y color:SolidPeso molecular:483.822-Linoleoyl Glycerol
CAS:2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.Fórmula:C21H38O4Forma y color:SolidPeso molecular:354.531GSK494581A
CAS:GSK494581A is a GPR55 agonist and glycine transporter subtype 1 inhibitor.Fórmula:C27H28F2N2O4SPureza:98%Forma y color:SolidPeso molecular:514.58PF 514273
CAS:PF 514273 is a CB1 receptor antagonist.Fórmula:C21H17Cl2F2N3O2Pureza:98%Forma y color:SolidPeso molecular:452.28PSNCBAM-1
CAS:PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo.Fórmula:C22H21ClN4OPureza:99.86%Forma y color:SolidPeso molecular:392.88Hemopressin(rat) TFA
CAS:Hemopressin(rat) TFA, a nonapeptide from hemoglobin α1-chain, selectively inhibits CB1 receptors and reduces inflammatory pain.Fórmula:C55H78F3N13O14Forma y color:SolidPeso molecular:1202.2811(Z),14(Z)-Eicosadienoic Acid Ethanolamide
CAS:11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide derivative of 11(Z),14(Z)-eicosadienoic acid.Fórmula:C22H41NO2Forma y color:SolidPeso molecular:351.57SAD-448
CAS:SAD-448 is a cannabinoid receptor type 1 (CB1) agonist. SAD-448 controls spasticity via action on the peripheral nerve CB1 receptor.Fórmula:C24H28N4O8SForma y color:SolidPeso molecular:532.57O-2545 hydrochloride
CAS:O-2545 is a potent water-soluble central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist with Ki values of 1.5 and 0.32 nM, respectively. Typically, cannabinoid agonists are highly lipophilic and require solubilization through surfactant agents or binding to water miscible substances like albumin, Tween 80, or Emulphor for use. When dissolved in saline, O-2545 has shown high efficacy in mouse behavioral models, administered either intravenously or intracerebroventricularly.Fórmula:C26H36N2O2HClForma y color:SolidPeso molecular:445Tricosanoyl Ethanolamide
CAS:Tricosanoyl ethanolamide, a fatty N-acyl ethanolamine within the endocannabinoid family, has an ethanolamine metabolite whose significance remains to be established.Fórmula:C25H51NO2Forma y color:SolidPeso molecular:397.688Isopropyl dodec-11-enylfluorophosphonate
CAS:Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibitsFórmula:C15H30FO2PPureza:98%Forma y color:SolidPeso molecular:292.37MCHB-1
CAS:MCHB-1, a potent agonist of the human cannabinoid 2 (CB2) receptor (EC50= 0.52 nM), demonstrates high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively), distinguishing itself from similar benzimidazole compounds that significantly alleviate peripheral pain while minimizing central nervous system side effects in mice.Fórmula:C28H37N3O2Forma y color:SolidPeso molecular:447.623CB1 antagonist 1
CAS:CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, andFórmula:C26H22Cl2N4Pureza:98%Forma y color:SolidPeso molecular:461.39Amauromine
CAS:Amauromine is a peripherally selective and potent cannabinoid receptor type 1 (CB1) receptor antagonist, a novel alkaloid with vasodilatory activity.Fórmula:C32H36N4O2Forma y color:SolidPeso molecular:508.65γ-Linolenoyl monoethanolamide
CAS:γ-Linolenoyl monoethanolamide, a fatty N-acyl ethanolamine, acts as an endocannabinoid [1] [2].Fórmula:C20H35NO2Forma y color:SolidPeso molecular:321.505CB 65
CAS:CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.Fórmula:C22H28ClN3O3Pureza:99.53%Forma y color:SolidPeso molecular:417.93(R)-Monlunabant
CAS:(R)-Monlunabant ((R)-MRI-1891) serves as a CB1 receptor antagonist utilized in obesity and metabolic disease research [1].Fórmula:C26H22ClF3N6O3SPureza:98%Forma y color:SolidPeso molecular:591CB1 inverse agonist 1
CAS:MRL-650 is an oral, selective CB1 agonist; IC50: CB1=7.5 nM, CB2=4100 nM; anorexigenic effects noted.Fórmula:C25H18Cl3N3O3Pureza:99.92%Forma y color:SolidPeso molecular:514.79Ref: TM-T10694
1mg50,00€5mg105,00€10mg155,00€25mg224,00€50mg314,00€100mg427,00€200mg577,00€1mL*10mM (DMSO)129,00€
