DHFR
La dihidrofolato reductasa (DHFR) es una enzima que desempeña un papel crucial en el ciclo del folato, esencial para la síntesis, reparación y metilación del ADN. Los inhibidores de DHFR se utilizan ampliamente como agentes quimioterapéuticos en el tratamiento del cáncer y las enfermedades autoinmunes debido a su capacidad para inhibir la proliferación celular. En CymitQuimica, ofrecemos una variedad de inhibidores de DHFR para apoyar su investigación en terapia contra el cáncer, inmunología y biología molecular.
Se han encontrado 30 productos de "DHFR"
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P 218
CAS:P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.Fórmula:C18H25ClN4O4Pureza:98.83%Forma y color:SoildPeso molecular:396.874-O-Methyldopamine hydrochloride
CAS:Compound PDK0318, with CAS No. 645-33-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0318 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C9H13NO2Forma y color:Slightly Beige Fluffy PowderPeso molecular:167.2DHFR-IN-16
DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 0.199 μM, and is valuable for anti-infection research.Fórmula:C32H34N4O4SPeso molecular:570.23008DHFR-IN-18
DHFR-IN-18 (compound 19D) is a DHFR inhibitor utilized in leukemia-related research.Fórmula:C24H22ClN7Peso molecular:443.16252EGFR/DHFR-IN-1
EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR, with IC50 values of 0.151 µM and 0.541 µM, respectively. It induces cell cycle arrest in the G0-G1 and S phases.Fórmula:C24H26N4O5S2Peso molecular:514.13446DHFR-IN-21
DHFR-IN-21 (compound 5p) is an inhibitor of dihydrofolate reductase.Forma y color:Odour SolidDHFR-IN-20
DHFR-IN-20 (Compound LA1) is an inhibitor of dihydrofolate reductase (DHFR) targeting the malignant strains of the malaria parasite. It exhibits inhibition constants (Kis) of 0.16 nM, 0.30 nM, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively. Additionally, DHFR-IN-20 demonstrates antimalarial activity, with IC50 values of 1.4 nM against parasites carrying the wild-type (TM4/8.2) PfDHFR enzyme and 1.6 μM against those with the quadruple mutation (V1/S)PfDHFR.Forma y color:Odour SolidCB 3705
CAS:CB 3705 is a bio-active chemical.Fórmula:C21H21N5O6Forma y color:SolidPeso molecular:439.42EGFR/HER2/DHFR-IN-2
EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively.Pureza:98%Forma y color:Odour SolidDHFR-IN-11
DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.Forma y color:Odour SolidTH9028 TFA
TH9028 TFA is an effective MTHFD2 inhibitor (IC50=11 nM) that suppresses proliferation in HL-60 cells, AML cells, and T-ALL Jurkat cells.Fórmula:C18H19F3N12O7Pureza:98.94% - 99.79%Peso molecular:572.42Ref: TM-T200757L
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar1mg264,00€Anti-Dihydrofolate reductase Antibody (2V859)
Anti-Dihydrofolate reductase Antibody (2V859) is an antibody targeting Dihydrofolate reductase. Anti-Dihydrofolate reductase Antibody (2V859) can be used in ELISA, WB, IHC, IP.Forma y color:Odour LiquidWR99210 hydrochloride(47326-86-3 free base)
CAS:WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.Fórmula:C14H19Cl4N5O2Pureza:97.77% - 99.8%Forma y color:SolidPeso molecular:431.14Ref: TM-T17257L
1mg62,00€5mg132,00€1mL*10mM (DMSO)157,00€10mg200,00€25mg338,00€50mg497,00€100mg708,00€200mg954,00€Piritrexim isethionate
CAS:Piritrexim isethionate, a fat-soluble DHFR inhibitor, shows efficacy in metastatic urothelial cancer with a 5-day oral regimen.Fórmula:C19H25N5O6SForma y color:SolidPeso molecular:451.49WR99210
CAS:WR99210 (BRL 6231 free base) is a DHFR inhibitor with antiparasitic activity.Fórmula:C14H18Cl3N5O2Pureza:98.8%Forma y color:SolidPeso molecular:394.68Fanotaprim
CAS:Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.Fórmula:C19H22N8OPureza:98.1%Forma y color:SolidPeso molecular:378.43Ref: TM-T36692
1mg50,00€2mg71,00€5mg110,00€1mL*10mM (DMSO)122,00€10mg170,00€25mg318,00€50mg442,00€100mg627,00€200mg845,00€DHFR-IN-3
CAS:DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.Fórmula:C8H7BrN4Pureza:99.521% - 99.65%Forma y color:SolidPeso molecular:239.07Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)
Key enzyme in folate metabolism.Forma y color:Lyophilized PowderPeso molecular:25.6 kDa (predicted)Ref: TM-TMPH-03535
5µg120,00€10µg195,00€20µg324,00€50µg489,00€100µg670,00€200µg964,00€500µg1.558,00€1mg2.277,00€Dihydrofolate reductase Protein, Human, Recombinant (His)
Key enzyme in folate metabolism.Forma y color:Lyophilized PowderPeso molecular:25.5 kDa (predicted)Ref: TM-TMPH-01224
5µg84,00€10µg120,00€20µg193,00€50µg290,00€100µg416,00€200µg631,00€500µg1.123,00€1mg1.700,00€Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)
Key enzyme in folate metabolism.Forma y color:Lyophilized PowderPeso molecular:22.0 kDa (predicted)Ref: TM-TMPH-03581
5µg130,00€10µg211,00€20µg351,00€50µg520,00€100µg714,00€200µg1.027,00€500µg1.607,00€1mg2.350,00€(Rac)-Managlinat dialanetil
CAS:Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.Fórmula:C21H33N4O6PSPureza:98.52%Forma y color:SolidPeso molecular:500.5510-Deazaaminopterin
CAS:10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.Fórmula:C20H21N7O5Forma y color:SolidPeso molecular:439.42Piritrexim
CAS:Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinomaFórmula:C17H19N5O2Pureza:98.50% - >99.99%Forma y color:SolidPeso molecular:325.37Clociguanil
CAS:Clociguanil has antimalarial activity.Fórmula:C12H15Cl2N5OForma y color:SolidPeso molecular:316.19Aditoprime
CAS:Aditoprime (Aditoprim) is a selective bacterial DHFR inhibitor with strong nanomolar potency and broad-spectrum antibacterial activity.Fórmula:C15H21N5O2Pureza:99.89%Forma y color:SolidPeso molecular:303.36DHFR-IN-5
CAS:DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.Fórmula:C18H24N4O4Forma y color:SolidPeso molecular:360.41Talotrexin ammonium
CAS:Talotrexin ammonium, a non-polyglutamic antifolate, inhibits cancer by targeting DHFR.
Fórmula:C27H30N10O6Pureza:97.49%Forma y color:SolidPeso molecular:590.59Ref: TM-T64295
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€Phototrexate
CAS:Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).Fórmula:C20H19N7O5Forma y color:SolidPeso molecular:437.41Methotrexate-γ-aspartate
CAS:Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.Fórmula:C24H27N9O8Pureza:98%Forma y color:SolidPeso molecular:569.53DHFR-IN-4
CAS:DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.Fórmula:C18H21N5O2SPureza:99.41%Forma y color:SolidPeso molecular:371.46
