Antibiótico

Ceftazidime Pentahydrate is a cephalosporin antibiotic with activity against gram-negative bacilli and may be used to study infectious diseases.

<p>Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.</p>

Polyoxin B is an antifungal peptidyl nucleoside antibiotic that inhibits fungal cell wall biosynthesis.

<p>Neomycin sulfate (Framycin sulfate) is a broad-spectrum aminoglycoside antibiotic that blocks the synthesis of bacterial proteins in order to exert</p>

Nisin A: a lantibiotic peptide made by L. lactis, contains unique amino acids like lanthionine, and fights bacteria.

Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.

Tirilazad mesylate (U 74006F) is a lipid peroxidation inhibitor with antiviral activity.Tirilazad mesylate is used in the study of neurological disorders.

<p>Fluconazole-d4 is a deuterated compound of Fluconazole. Fluconazole has a CAS number of 86386-73-4. Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.</p>

AB47 is a bacterial peptide deformylases inhibitor.

<p>Chloroquine: treats malaria, amebiasis, rheumatoid arthritis, lupus; works by inhibiting parasites in red blood cells.</p>

PNU 142300 is an inactive metabolite of the oxazolidinone antibiotic linezolid .

<p>Epitetracycline is an epimer of the antibiotic tetracycline . Epimers of tetracycline form without catalysis and are considered degradation products. Epitetracycline has decreased activity as an antibiotic or a Tet repressor effector but may have stronger toxic effects in animals.</p>

<p>L-(+)-Ampicillin is an isomer of Ampicillin. Ampicillin is a β-lactam antibiotic used for treating bacterial infections.</p>

<p>N4Py is a good synthetic mimic of the Bleomycins (BLMs), which are a family of natural antibiotics used clinically in the treatment of certain cancers.</p>

<p>L-Azatyrosine from Streptomyces chibaensis is an antitumor antibiotic reversing Ras-transformed cell behavior.</p>

<p>Tebipenem is an orally available carbapenem antibiotic. It displays broad-spectrum activity against Gram-positive and -negative bacteria.</p>

Sinafloxacin Mesylate is a quinolone antibiotic potentially for the treatment of bacterial infections.

Tauroxicum (Taurox) is formulated by COBAT to reduce fatigue and improve quality of life.

<p>Azaserine (CI-337) is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.</p>

<p>Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.</p>

Lincomycin-B is a lincosamide antibiotic isolated from the actinomycete Streptomyces lincolnensis.

Deacetylcephalothin Sodium Salt is an impurity in the synthesis of Cefalonium. It used as a long-acting intramammary cerate for the infusion of dairy cows.

Vincristine, a microtubule disruptor, inhibits mitosis in cancer cells, useful in leukemia research.

Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.

Xenalamine is a synthetic compound of antiviral.

CRK12-IN-1: strong inhibitor of CRK12, kills T.b. brucei & T. congolense (EC50s: 1.3 & 18 nM).

SQ109 (NSC-722041) is an effective inhibitor of the trypomastigote form of the parasite (IC50 = 50 nM). SQ109 is an antitubercular agent and targets MmpL3.

DDD01035881 is a anti-malarial drug that blocks parasite-to-mosquito transmission by targeting the Plasmodium vesicle membrane protein Pfs16.

<p>Chitin synthase inhibitor 4: a CHS inhibitor with antimicrobial properties, potential fungicide.</p>

Roridin E blocks FGFR3, IGF-1R, PDGFRβ, TrkB (IC50s: 0.4–1.4 μM), kills breast cancer cells (IC50: 0.02-0.05 nM), and halts other cancer cells (<0.01 μM).

PD 117588: Broad-spectrum quinolone; combats Gram-positive and most Gram-negative bacteria, barring P. aeruginosa. More potent than imipenem or ceftazidime.

Ormetoprim (Ro 5-9754), an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture.

Basacv is a bisacridinyl peptidic analog of triostin A.

SSJ-183 is a low-toxicity and orally available and anti-malarial drug with an IC50 = 7.6 nM against P. falciparum and no lethality at doses up to 2000 mg/kg po.

<p>AFK-108 is a fungicide agent.</p>

Lincophenicol is an Escherichia coli ribosomal peptidyltransferase-catalyzed puromycin reaction inhibitor.

Rosaramicin, a lipid-soluble basic macrolide, is an antibacterial substance similar to erythromycin but with a better activity against Gram-negative bacteria.

<p>Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.</p>

<p>Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.</p>

S 863390 is a renin inhibitor.

Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).

Tunicamine is a reversible polyprenol-phosphate inhibitor.

Vidarabine phosphate is an adenosine monophosphate analog.

Saquayamycin B, a glycoside, targets Gram-positive bacteria and both adriamycin-sensitive and -resistant P388 leukemia cells.

<p>4-((4-((4-Aminophenyl)sulfonyl)phenyl)amino)-4-oxobutanoic acid is a sulfonamide compound that can be used as an anti infective agent [1].</p>

Compound 5, an antiviral agent, effectively targets murine norovirus, with potential in infectious disease and oncology research.

Abimtrelvir exhibited antiviral activity.

Phenosulfazole is a potent antiviral agent which has the potential for the research of poliomyelitis virus [1].

RMI 10874 is a tilorone analogue. Tilorone is an orally bioavailable antiviral agent.

Pentachloropseudilin inhibits Myosin-1 and speeds up TGF-β receptor turnover, suppressing TGF-β activity.

<p>Acyclovir monophosphate, a strong anti-HSV agent, inhibits viral DNA polymerase, blocking DNA synthesis and chain elongation.</p>

Riodoxol is an antiviral agent that effectively affects the reproduction and maturation of viruses.

<p>FR900098, a fosmidomycin derivative, has potent antimalarial effects, targeting DOXP reductoisomerase and eradicating P. vinckei in mice at &gt;10 mg/kg.</p>

Verticillin A, an apoptosis inducer, inhibits Leiomyosarcoma and Malignant peripheral nerve sheath tumor growth.

Chitin synthase inhibitor 2 (2b) has an IC50 of 0.09 mM, K i 0.12 mM, shows in vitro antimicrobial activity and boosts fluconazole/polyoxin B.

Pyrrofolic acid shows high anti-folate biological activity for S. faecalis.

MptpB-IN-1: orally active, potent MptpB inhibitor; reduces drug-resistant tuberculosis.

BRD-8000.3 is a narrow-spectrum antimycobacterial targeting EfpA, inhibiting lipid transport in drug-tolerant Mtb and useful in structural and functional.

Alalevonadifloxacin HCl is a novel l-alanine ester prodrug of levonadifloxacin.

LY 186826 is an antibacterial agent with bicyclic pyrazolidinone properties.

Amcinafal is an active diol,and used against virus replication and interferon production.

Linogliride: a guanidine derivative, inhibits insulin release, and enhances glucose tolerance by blocking ATP-sensitive K+ channels in pancreatic beta cells.

Epirubicin, a doxorubicin derivative, is an antineoplastic, inhibits topoisomerase, DNA/RNA synthesis, and Foxp3, reducing T cell activity.

Ferric citrate as a source of iron used in cell culture applications can provide iron with a less toxic form compared to free iron salts.

Pafuramidine is an orally bioavailable prodrug of formamidine which was developed for the treatment of human African trypanosomiasis.

Exeporfinium chloride(XF-73) is an antimicrobial agent that can weaken bacterial cell walls.

<p>Albitiazolium bromide is an antimalarial compound disrupting phosphatidylcholine biosynthesis in Plasmodium, transported via NPP and cation carriers.</p>

Linogliride fumarate, a guanidine derivative, stimulates insulin release by blocking ATP-sensitive K+ channels, enhancing glucose tolerance.

Carnidazole (ME-108) shows antiprotozoal activity and can be used in studies about the treatment of Trichomonas infection.

Clofoctol is a bacteriostatic antibiotic with activity against Gram-positive bacteria, used in the treatment of upper and lower respiratory tract infections.

<p>Azidamfenicol inhibits ribosomal peptidyltransferase with a Ki of 22 µM. Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic.</p>

<p>Quinupristin, a macrolide-lincosamide-streptogramin antibiotic, inhibits protein synthesis in bacteria.</p>

Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes.

<p>Nortopixantrone HCl (BBR 3438) is a novel 9-azacyclonopyrazole that shows antitumor activity in a human prostate cancer model.</p>

Antiviral agent 17, EC50 0.015 μM in human assay, effective against murine norovirus, may aid infectious/malignant disease research.

<p>Oseltamivir acid methyl ester, a CES1-convertible neuraminidase inhibitor, serves as an antiviral prodrug.</p>

Aranciamycin (Compound 1), an anthracycline antibiotic, exhibits collagenase inhibitory activity (IC50 3.7*10^-7 M) and can inhibit DNA synthesis in tumor cells

Compound 6d (Antibacterial agent 159) is an antibiotic effective against impetigo and Clostridium difficile infection (CDI), with no observed recurrence for CDI

Myxopyronin A is an inhibitor of bacterial RNA polymerase.

N-Acetylpurinomycin is a selective agonist of CB2 receptor.

SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor, demonstrating potent antifungal activity with an inhibition concentration (IC50) of 7.2 μg/mL and an

<p>N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) serves as an autoregulator for carbapenem antibiotic biosynthesis in Erwinia carotovora ATCC 39048 and induces the expression of rhiI in R. leguminosarum [1].</p>

4'-Acetyl-chrysomycin B, a 4'-acetylated analog of chrysomycin B, exhibits anti-Gram-positive bacterial and antimicrobial activities [1].

Nilofabicin (CG-400549) is a potent inhibitor of enoyl-(acyl-carrier-protein) reductase fall(FabI) and can be used in studies about the treatment of complicated

<p>CcpA-IN-1 is a Staphylococcus aureus antibiotic exhibiting significant bactericidal activity (MICs=460 nM) [1].</p>

<p>Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).</p>

<p>Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound.</p>

S-Adenosylhomocysteine (SAH) hydrolase is responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of this enzyme leads to the accumulation of SAH within cells, thereby increasing the SAH to S-adenosylmethionine (SAM) ratio and subsequently inhibiting SAM-dependent methyltransferases. (−)-Neplanocin A, a potent and irreversible inhibitor of SAH hydrolase (Ki= 8.39 nM), exhibits significant antitumor activity against mouse leukemia L1210 cells and holds broad-spectrum antiviral properties. Its efficacy notably surpasses that of the reversible inhibitor 3-deazaneplanocin, especially in combating vesicular stomatitis, evidencing a higher potency with ID50 values of 0.07 μg/ml for Neplanocin A versus 0.3 μg/ml for 3-deazaneplanocin.

Annamycin, a semi-synthetic doxorubicin derivative, binds DNA, blocks topoisomerase II, and evades MDR, inhibiting DNA/RNA/protein synthesis.

Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.

Gusperimus trihydrochloride is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity.

OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M.

Pristinamycin IA (Mikamycin B) is a substrate for the P-glycoprotein and a cyclo-peptidic macrolactone antibiotic.

β-Lactamase-IN-2 is an inhibitor of β-Lactamase with anti-microbial and anti-bacterial effects.

Alatrofloxacin is a prodrug of trovafloxacin.

AS-2077715, an antifungal agent, exhibits inhibitory activity against Trichophyton species and is derived from the fermentation broth of Capnodium sp. 339855. It is utilized in the study of fungal infections [1].

Berkeleylactone E, a macrolide antibiotic [1], exhibits antimicrobial properties.

Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).

Cladosporin, from Cladosporium cladosporioid fungus, halts dermatophyte growth on agar at 75 μg/mL.

<p>DuP-721: broad-spectrum, oral antibiotic targeting various bacteria, including M. tuberculosis.</p>

Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.

<p>2-Acetyl-2-decarboxamidotetracycline is a tetracycline-class antibiotic. It exhibits a UV absorption spectrum similar to that of tetracycline or 5-oxytetracycline at concentrations above 300 mμ, characteristic of the BCD ring system.</p>