Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

Mostrar 2 subcategorías más

Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

Pureza (%)

100

productos por página.

+ Info
Tyrphostin B44, (+) enantiomer
CAS:
- 133550-37-5
Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)
Fórmula:C₁₈H₁₆N₂O₃
Pureza:97.18%
Forma y color:Solid
Peso molecular:308.33
Ref: TM-T22450
+ Info
CC-115 hydrochloride
CAS:
- 1300118-55-1
CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.
Fórmula:C₁₆H₁₇ClN₈O
Forma y color:Solid
Peso molecular:372.82
Ref: TM-T61505
+ Info
GSK2334470
CAS:
- 1227911-45-6
GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.
Fórmula:C₂₅H₃₄N₈O
Pureza:99.57% - 99.87%
Forma y color:Solid
Peso molecular:462.59
Ref: TM-T2348
+ Info
GNE-317
CAS:
- 1394076-92-6
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
Fórmula:C₁₉H₂₂N₆O₃S
Pureza:98.42% - 99.54%
Forma y color:Solid
Peso molecular:414.48
Ref: TM-T6845
+ Info
Autogramin-1
CAS:
- 2375541-73-2
Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.
Fórmula:C₂₃H₂₇N₅O₅S
Pureza:97.69% - 99.25%
Forma y color:Solid
Peso molecular:485.56
Ref: TM-T10413
+ Info
RSVA405
CAS:
- 140405-36-3
RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
Fórmula:C₁₇H₂₀N₄O₂
Pureza:99.30%
Forma y color:Solid
Peso molecular:312.37
Ref: TM-T8476
+ Info
TGX-221
CAS:
- 663619-89-4
TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.
Fórmula:C₂₁H₂₄N₄O₂
Pureza:99.68% - >99.99%
Forma y color:Solid
Peso molecular:364.44
Ref: TM-T2661
+ Info
AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
Fórmula:C₁₆H₁₅ClIN₃O₂
Pureza:98.64%
Forma y color:Solid
Peso molecular:443.66
Ref: TM-T4694
+ Info
IM-12
CAS:
- 1129669-05-1
IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.
Fórmula:C₂₂H₂₀FN₃O₂
Pureza:99.42% - >99.99%
Forma y color:Solid
Peso molecular:377.41
Ref: TM-T2261
+ Info
Trastuzumab
CAS:
- 180288-69-1
Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.
Pureza:98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%
Forma y color:Liquid
Peso molecular:Approximately 145.53 kDa
Ref: TM-T9912
+ Info
MOTS-c(Human) Acetate(1627580-64-6 free)
MOTS-c(Human) Acetate is a mitochondrial-derived peptide.
Fórmula:C₁₀₃H₁₅₆N₂₈O₂₄S₂
Pureza:100%
Forma y color:Solid
Peso molecular:2234.64
Ref: TM-TP2312
+ Info
AZD 6482
CAS:
- 1173900-33-8
AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.
Fórmula:C₂₂H₂₄N₄O₄
Pureza:99.79% - 99.95%
Forma y color:Solid
Peso molecular:408.45
Ref: TM-T6087
+ Info
BI-4020
CAS:
- 2664214-60-0
BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.
Fórmula:C₃₀H₃₈N₈O₂
Pureza:97.21% - >99.99%
Forma y color:Solid
Peso molecular:542.68
Ref: TM-T10534
+ Info
AEE788
CAS:
- 497839-62-0
AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.
Fórmula:C₂₇H₃₂N₆
Pureza:98% - >99.99%
Forma y color:Solid
Peso molecular:440.58
Ref: TM-T2116
+ Info
VS-5584
CAS:
- 1246560-33-7
VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.
Fórmula:C₁₇H₂₂N₈O
Pureza:97.82% - 99.54%
Forma y color:Solid
Peso molecular:354.41
Ref: TM-T6103
+ Info
(S)-Sunvozertinib
CAS:
- 2370013-49-1
(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
Fórmula:C₂₉H₃₅ClFN₇O₃
Pureza:99.64%
Forma y color:Solid
Peso molecular:584.08
Ref: TM-T9304
+ Info
KU-0063794
CAS:
- 938440-64-3
KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.
Fórmula:C₂₅H₃₁N₅O₄
Pureza:98.21% - >99.99%
Forma y color:Solid
Peso molecular:465.54
Ref: TM-T2475
+ Info
GS87
CAS:
- 919936-70-2
GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.
Fórmula:C₁₆H₁₁N₅O₂S
Pureza:98.86%
Forma y color:Solid
Peso molecular:337.36
Ref: TM-T8605
+ Info
Voxtalisib
CAS:
- 934493-76-2
Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
Fórmula:C₁₃H₁₄N₆O
Pureza:98.21% - 99.69%
Forma y color:Solid
Peso molecular:270.29
Ref: TM-T7014
+ Info
GNF4877
CAS:
- 2041073-22-5
GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.
Fórmula:C₂₅H₂₇FN₆O₄
Pureza:98.68% - 99.40%
Forma y color:Solid
Peso molecular:494.52
Ref: TM-T11447