mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Se han encontrado 163 productos para "mTOR".
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WYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Fórmula:C28H32N8O3Pureza:99.93%Forma y color:SolidPeso molecular:528.61NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Fórmula:C7H13F2NO2Pureza:98% - ≥98%Forma y color:SolidPeso molecular:181.18Ref: TM-T12270
1mg94,00€1mL*10mM (DMSO)166,00€5mg203,00€10mg326,00€25mg698,00€50mg1.108,00€100mg1.603,00€NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Fórmula:C29H27F2N5O5S2Pureza:99.58%Forma y color:SolidPeso molecular:627.68Ref: TM-T16355
2mg39,00€5mg60,00€1mL*10mM (DMSO)84,00€10mg87,00€25mg159,00€50mg231,00€100mg355,00€200mg505,00€MT 63-78
CAS:MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).Fórmula:C21H14N2O2Pureza:97.11% - 98.95%Forma y color:White SolidPeso molecular:326.35Ref: TM-T16156
1mg84,00€5mg160,00€1mL*10mM (DMSO)167,00€10mg260,00€25mg440,00€50mg628,00€100mg872,00€Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Fórmula:C21H27ClN2S2Pureza:99.55% - 99.95%Forma y color:White SolidPeso molecular:407.04SN32976
CAS:SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.Fórmula:C24H33F2N9O4SPureza:98.06%Forma y color:SolidPeso molecular:581.64Rapamycin
CAS:Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.Fórmula:C51H79NO13Pureza:97.08% - 99.90%Forma y color:White SolidPeso molecular:914.17Ref: TM-T1537
10mg34,00€25mg46,00€1mL*10mM (DMSO)48,00€50mg50,00€100mg65,00€200mg101,00€500mg178,00€1g268,00€AJ2-30
CAS:AJ2-30: Inhibits SLCl5A4, TLR9-B cell activation, MDP transport, NOD signaling; for inflammation study.Fórmula:C23H22N4Pureza:99.93%Forma y color:SoildPeso molecular:354.45Ref: TM-T77644
1mg48,00€5mg101,00€1mL*10mM (DMSO)114,00€10mg167,00€25mg334,00€50mg537,00€100mg762,00€200mg1.018,00€(32-Carbonyl)-RMC-5552
CAS:(32-Carbonyl)-RMC-5552, a potent mTOR inhibitor, blocks mTORC1/C2, with pIC50 values >9 for p-P70S6K and p-4E-BP1, and 8~9 for p-AKT1/2/3.Fórmula:C93H134N10O24Forma y color:SolidPeso molecular:1776.1412DII
2DII is a potent and selective mTORC2 inhibitor. It specifically binds to the mSin1 PH domain, resulting in a decreased phosphorylation of AKT1.Fórmula:C54H76ClN7O11SForma y color:SolidPeso molecular:1066.74RMC-4529
CAS:RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.Fórmula:C90H139N13O23Forma y color:SolidPeso molecular:1771.17mTOR inhibitor WYE-28
CAS:mTOR inhibitor WYE-28, Potent mTOR (IC50=0.08 nM) and PI3Kα (IC50=6 nM) inhibitor, short half-life in mouse microsomes.Fórmula:C30H34N8O5Pureza:98.13%Forma y color:Orange SolidPeso molecular:586.65RMC-6272
CAS:RMC-6272 (RM-006) is a bi-steric mTORC1 inhibitor with selective potency over mTORC2 and shows greater effects than Rapamycin on TSC2-deficient tumors.Fórmula:C95H141FN6O27SForma y color:SolidPeso molecular:1850.25PF-06465603
CAS:PF-06465603 is a metabolite of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR.Fórmula:C22H25N5O5Forma y color:SolidPeso molecular:439.46PI3K-IN-22
CAS:PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.Fórmula:C31H35F3N8O3Forma y color:SolidPeso molecular:624.66MCX 28
CAS:MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.Fórmula:C25H19N5O4S3Forma y color:SolidPeso molecular:549.64RMC-4627
CAS:RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.Fórmula:C93H141N11O23Forma y color:SolidPeso molecular:1781.17PI3K-AKT-mTOR Compound Library
A unique collection of xnum compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;Forma y color:Odour SolidRef: TM-L1300
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarFDA-Approved Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Forma y color:LiquidRef: TM-L1610
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultardTAGV-1 TFA
CAS:dTAGV-1 TFA is a highly selective VHL-dependent PROTAC-mediated protein degrader that specifically targets and degrades mutant FKBP12 fusion proteins.Fórmula:C70H91F3N6O16SPureza:99.73%Forma y color:White SolidPeso molecular:1361.58
