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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • AZ-5104
    Targetmol
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    AZ-5104

    CAS:
    <p>AZ5104 is a potent EGFR inhibitor.</p>
    Fórmula:C27H31N7O2
    Pureza:98.40% - 99.59%
    Forma y color:Solid Powder
    Peso molecular:485.58

    Ref: TM-T2491

  • WS6
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    WS6

    CAS:
    <p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>
    Fórmula:C29H31F3N6O3
    Pureza:97.65% - 99.95%
    Forma y color:Solid
    Peso molecular:568.59

    Ref: TM-T2106

  • Selective PI3Kδ Inhibitor 1
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    Selective PI3Kδ Inhibitor 1

    CAS:
    <p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>
    Fórmula:C23H20FN7O
    Pureza:97.96%
    Forma y color:Solid
    Peso molecular:429.45

    Ref: TM-T5831

  • PKI-166 hydrochloride
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    PKI-166 hydrochloride

    CAS:
    <p>EGFR-kinase inhibitor, IC50 0.7 nM, &gt;3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>
    Fórmula:C20H19ClN4O
    Forma y color:Solid
    Peso molecular:366.85

    Ref: TM-T36643

  • Autophinib
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    Autophinib

    CAS:
    <p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>
    Fórmula:C14H11ClN6O3
    Pureza:99.25% - 99.41%
    Forma y color:Solid
    Peso molecular:346.73

    Ref: TM-T4219

  • NRC-2694
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    NRC-2694

    CAS:
    <p>NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.</p>
    Fórmula:C24H26N4O3
    Pureza:99.90%
    Forma y color:Solid
    Peso molecular:418.49

    Ref: TM-T16343

  • YKL-06-061
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    YKL-06-061

    CAS:
    <p>YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.</p>
    Fórmula:C30H37N7O2
    Pureza:99.52% - 99.79%
    Forma y color:Solid
    Peso molecular:527.66

    Ref: TM-T5576

  • CL-387785
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    CL-387785

    CAS:
    <p>CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.</p>
    Fórmula:C18H13BrN4O
    Pureza:99.56% - 99.62%
    Forma y color:Solid
    Peso molecular:381.23

    Ref: TM-T2245

  • WS3
    Targetmol
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    WS3

    CAS:
    <p>WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>
    Fórmula:C28H30F3N7O3
    Pureza:97.93% - 99.94%
    Forma y color:Solid
    Peso molecular:569.58

    Ref: TM-T2055

  • CP-380736
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    CP-380736

    CAS:
    <p>CP-380736 (PF-00520893) inhibits EGFR, a kinase key in cancer-signaling pathways like MAPK, JNK, and Akt.</p>
    Fórmula:C14H18N2O5
    Pureza:99.68%
    Forma y color:White To Off-White Solid
    Peso molecular:294.3

    Ref: TM-T19814

  • TAS0728
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    TAS0728

    CAS:
    <p>TAS0728 is a HER2 inhibitor, with antitumor activity</p>
    Fórmula:C26H32N8O3
    Pureza:97.78%
    Forma y color:Solid
    Peso molecular:504.58

    Ref: TM-T7819

  • Mutant EGFR inhibitor
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    Mutant EGFR inhibitor

    CAS:
    <p>Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.</p>
    Fórmula:C27H30ClN7O2
    Pureza:98% - 99.75%
    Forma y color:Solid
    Peso molecular:520.03

    Ref: TM-T2705

  • KY19382
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    KY19382

    CAS:
    <p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>
    Fórmula:C17H11Cl2N3O2
    Pureza:98.06%
    Forma y color:Solid
    Peso molecular:360.19

    Ref: TM-T9025

  • RG13022
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    RG13022

    CAS:
    <p>RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).</p>
    Fórmula:C16H14N2O2
    Pureza:98.38%
    Forma y color:Solid
    Peso molecular:266.29

    Ref: TM-T3545

  • Bisindolylmaleimide I
    Targetmol
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    Bisindolylmaleimide I

    CAS:
    <p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>
    Fórmula:C25H24N4O2
    Pureza:98.19% - 98.75%
    Forma y color:Orange Solid
    Peso molecular:412.48

    Ref: TM-T6513

  • NU 7026
    Targetmol
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    NU 7026

    CAS:
    <p>NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition</p>
    Fórmula:C17H15NO3
    Pureza:99.51% - >99.99%
    Forma y color:Solid
    Peso molecular:281.31

    Ref: TM-T2433

  • KI8751
    Targetmol
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    KI8751

    CAS:
    <p>KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.</p>
    Fórmula:C24H18F3N3O4
    Pureza:99.22% - 99.9%
    Forma y color:Solid
    Peso molecular:469.41

    Ref: TM-T2446

  • JCN037
    Targetmol
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    JCN037

    CAS:
    <p>JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).</p>
    Fórmula:C16H11BrFN3O2
    Pureza:99.5%
    Forma y color:Solid
    Peso molecular:376.18

    Ref: TM-T8431

  • ETP-46321
    Targetmol
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    ETP-46321

    CAS:
    <p>ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).</p>
    Fórmula:C20H27N9O3S
    Pureza:99.8%
    Forma y color:Solid
    Peso molecular:473.55

    Ref: TM-TQ0229

  • PF-6274484
    Targetmol
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    PF-6274484

    CAS:
    <p>PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.</p>
    Fórmula:C18H14ClFN4O2
    Pureza:97.71%
    Forma y color:Solid
    Peso molecular:372.78

    Ref: TM-T22396