Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
- AMPK(158 productos)
- ATM / ATR(71 productos)
- ADN-PK(51 productos)
- EGFR(572 productos)
- MELK(7 productos)
- PDK(9 productos)
- PI3K(242 productos)
- Quinasa S6(9 productos)
- gsk-3(112 productos)
- mTOR(144 productos)
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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"
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Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Fórmula:C25H24N4O2Pureza:98.19% - 98.75%Forma y color:Orange SolidPeso molecular:412.48NU 7026
CAS:<p>NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition</p>Fórmula:C17H15NO3Pureza:99.51% - >99.99%Forma y color:SolidPeso molecular:281.31KI8751
CAS:<p>KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.</p>Fórmula:C24H18F3N3O4Pureza:99.22% - 99.9%Forma y color:SolidPeso molecular:469.41JCN037
CAS:<p>JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).</p>Fórmula:C16H11BrFN3O2Pureza:99.5%Forma y color:SolidPeso molecular:376.18UCB9608
CAS:<p>UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.</p>Fórmula:C20H26N8O2Pureza:97.53% - 99.59%Forma y color:SolidPeso molecular:410.47PF-6274484
CAS:<p>PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.</p>Fórmula:C18H14ClFN4O2Pureza:97.71%Forma y color:SolidPeso molecular:372.78Alflutinib
CAS:<p>Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.</p>Fórmula:C28H31F3N8O2Pureza:99.87%Forma y color:SolidPeso molecular:568.59KU-57788
CAS:<p>NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).</p>Fórmula:C25H19NO3SPureza:98% - >99.99%Forma y color:SolidPeso molecular:413.49MOMIPP
CAS:<p>MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.</p>Fórmula:C18H16N2O2Pureza:99.66%Forma y color:SolidPeso molecular:292.33ZSTK474
CAS:<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Fórmula:C19H21F2N7O2Pureza:98.29% - 99.95%Forma y color:White PowderPeso molecular:417.41Neratinib
CAS:<p>Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.</p>Fórmula:C30H29ClN6O3Pureza:96.17% - 99.85%Forma y color:SolidPeso molecular:557.04AZD8931 diFuMaric acid
CAS:<p>AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).</p>Fórmula:C31H33ClFN5O11Pureza:99.92%Forma y color:SolidPeso molecular:706.1KenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Fórmula:C16H11BrN2OPureza:97.14% - 98.99%Forma y color:Tan SolidPeso molecular:327.18PIK-108
CAS:<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Fórmula:C22H24N2O3Pureza:98.92%Forma y color:SolidPeso molecular:364.44AG-494
CAS:<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Fórmula:C16H12N2O3Pureza:98.69%Forma y color:SolidPeso molecular:280.28Lazertinib
CAS:<p>Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.</p>Fórmula:C30H34N8O3Pureza:98.7% - 99.90%Forma y color:SolidPeso molecular:554.64Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Fórmula:C35H28F3N5O2Pureza:98.3% - 99.33%Forma y color:SolidPeso molecular:607.62Idelalisib
CAS:<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Fórmula:C22H18FN7OPureza:98% - 99.39%Forma y color:SolidPeso molecular:415.42GNE-493
CAS:<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Fórmula:C17H20N6O2SPureza:98%Forma y color:SolidPeso molecular:372.44HTH-01-015
CAS:<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Fórmula:C26H28N8OPureza:98.38% - 99.70%Forma y color:SolidPeso molecular:468.55
