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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • β-Hydroxyisovalerylshikonin
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    β-Hydroxyisovalerylshikonin

    CAS:
    <p>Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor</p>
    Fórmula:C21H24O7
    Pureza:98.16%
    Forma y color:Solid
    Peso molecular:388.41

    Ref: TM-TN1440

  • PP 3
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    PP 3

    CAS:
    <p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>
    Fórmula:C11H9N5
    Pureza:98.61%
    Forma y color:Whit To Off-White Solid
    Peso molecular:211.22

    Ref: TM-T23176

  • UCB9608
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    UCB9608

    CAS:
    <p>UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.</p>
    Fórmula:C20H26N8O2
    Pureza:97.53% - 99.59%
    Forma y color:Solid
    Peso molecular:410.47

    Ref: TM-TQ0009

  • ZM39923 hydrochloride
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    ZM39923 hydrochloride

    CAS:
    <p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>
    Fórmula:C23H25NO·HCl
    Pureza:98.05%
    Forma y color:Solid
    Peso molecular:367.91

    Ref: TM-T6145

  • BpV(HOpic)
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    BpV(HOpic)

    CAS:
    <p>BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).</p>
    Fórmula:C6H4K2NO8V
    Pureza:99.60%
    Forma y color:Solid
    Peso molecular:347.24

    Ref: TM-T7953

  • KY19382
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    KY19382

    CAS:
    <p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>
    Fórmula:C17H11Cl2N3O2
    Pureza:98.06%
    Forma y color:Solid
    Peso molecular:360.19

    Ref: TM-T9025

  • YKL-05-099
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    YKL-05-099

    CAS:
    <p>YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. It can inhibit the activity of SIK1 and SIK3.Cost-effective and quality-assured.</p>
    Fórmula:C32H34ClN7O3
    Pureza:99.57% - 99.66%
    Forma y color:Solid
    Peso molecular:600.11

    Ref: TM-T17271

  • Derazantinib dihydrochloride
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    Derazantinib dihydrochloride

    CAS:
    <p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>
    Fórmula:C29H31Cl2FN4O
    Forma y color:Solid
    Peso molecular:541.49

    Ref: TM-T70143

  • 4-Chloro-2'-bromoacetophenone
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    4-Chloro-2'-bromoacetophenone

    CAS:
    <p>4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).</p>
    Fórmula:C8H6BrClO
    Pureza:98.34% - 99.41%
    Forma y color:White To Beige Solid
    Peso molecular:233.49

    Ref: TM-T8908

  • WHI-P180
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    WHI-P180

    CAS:
    <p>WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.</p>
    Fórmula:C16H15N3O3
    Pureza:99.21%
    Forma y color:Solid
    Peso molecular:297.31

    Ref: TM-T2032

  • Saracatinib
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    Saracatinib

    CAS:
    <p>Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.</p>
    Fórmula:C27H32ClN5O5
    Pureza:98% - 99.63%
    Forma y color:Solid
    Peso molecular:542.03

    Ref: TM-T6078

  • mTOR inhibitor-1
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    mTOR inhibitor-1

    CAS:
    <p>C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.</p>
    Fórmula:C16H15BrN2O3
    Pureza:99.43%
    Forma y color:Solid
    Peso molecular:363.21

    Ref: TM-T5338

  • NIH-12848
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    NIH-12848

    CAS:
    <p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>
    Fórmula:C20H14F3N3S
    Pureza:99.84% - 99.9%
    Forma y color:Solid
    Peso molecular:385.41

    Ref: TM-T3556

  • AMG319
    Targetmol
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    AMG319

    CAS:
    <p>AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, &gt;47-fold selectivity over other PI3Ks. Phase 2.</p>
    Fórmula:C21H16FN7
    Pureza:98.9% - 99.24%
    Forma y color:Crystalline Solid
    Peso molecular:385.4

    Ref: TM-T6757

  • GNE-493
    Targetmol
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    GNE-493

    CAS:
    <p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>
    Fórmula:C17H20N6O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:372.44

    Ref: TM-T7166

  • BGT226
    Targetmol
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    BGT226

    CAS:
    <p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>
    Fórmula:C28H25F3N6O2
    Pureza:95.74% - 99.51%
    Forma y color:Solid
    Peso molecular:534.53

    Ref: TM-T6072L

  • TAS0728
    Targetmol
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    TAS0728

    CAS:
    <p>TAS0728 is a HER2 inhibitor, with antitumor activity</p>
    Fórmula:C26H32N8O3
    Pureza:97.78%
    Forma y color:Solid
    Peso molecular:504.58

    Ref: TM-T7819

  • PKD-IN-1 dihydrochloride (956121-30-5 free base)
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    PKD-IN-1 dihydrochloride (956121-30-5 free base)

    CAS:
    <p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>
    Fórmula:C18H21Cl3N4O
    Pureza:99.5%
    Forma y color:Solid
    Peso molecular:415.75

    Ref: TM-T8957L

  • WHI-P154
    Targetmol
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    WHI-P154

    CAS:
    <p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>
    Fórmula:C16H14BrN3O3
    Pureza:98% - 99.67%
    Forma y color:Solid
    Peso molecular:376.2

    Ref: TM-T1985

  • HG-14-10-04
    Targetmol
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    HG-14-10-04

    CAS:
    <p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>
    Fórmula:C29H34ClN7O
    Pureza:99.75% - >99.99%
    Forma y color:Solid
    Peso molecular:532.08

    Ref: TM-T4015