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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • EAI045
    Targetmol
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    EAI045

    CAS:
    <p>EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.</p>
    Fórmula:C19H14FN3O3S
    Pureza:98.00% - 99.12%
    Forma y color:Solid
    Peso molecular:383.4

    Ref: TM-T6824

  • Chrysophanol
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    Chrysophanol

    CAS:
    <p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>
    Fórmula:C15H10O4
    Pureza:99.44% - 99.91%
    Forma y color:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°C
    Peso molecular:254.24

    Ref: TM-T2995

  • PI-3065
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    PI-3065

    CAS:
    <p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>
    Fórmula:C27H31FN6OS
    Pureza:99.84% - ≥95%
    Forma y color:Solid
    Peso molecular:506.64

    Ref: TM-T2083

  • TBB
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    TBB

    CAS:
    <p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>
    Fórmula:C6HBr4N3
    Pureza:98.51% - 99.45%
    Forma y color:Off-White Solid
    Peso molecular:434.71

    Ref: TM-T2695

  • Linperlisib
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    Linperlisib

    CAS:
    <p>Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ</p>
    Fórmula:C28H37FN6O5S
    Pureza:99.01%
    Forma y color:Solid
    Peso molecular:588.69

    Ref: TM-T6330

  • TGX-221
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    TGX-221

    CAS:
    <p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>
    Fórmula:C21H24N4O2
    Pureza:99.68% - >99.99%
    Forma y color:Solid
    Peso molecular:364.44

    Ref: TM-T2661

  • WZ4003
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    WZ4003

    CAS:
    <p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>
    Fórmula:C25H29ClN6O3
    Pureza:99.65% - >99.99%
    Forma y color:Solid
    Peso molecular:496.99

    Ref: TM-T6291

  • RSVA405
    Targetmol
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    RSVA405

    CAS:
    <p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>
    Fórmula:C17H20N4O2
    Pureza:99.30%
    Forma y color:Solid
    Peso molecular:312.37

    Ref: TM-T8476

  • SU5214
    Targetmol
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    SU5214

    CAS:
    <p>SU5214 is a modulator of tyrosine kinase signal transduction.</p>
    Fórmula:C16H13NO2
    Pureza:99.45% - 99.55%
    Forma y color:Solid
    Peso molecular:251.28

    Ref: TM-T3569

  • OTSSP167
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    OTSSP167

    CAS:
    <p>OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.</p>
    Fórmula:C25H28Cl2N4O2
    Pureza:98.22% - 99.47%
    Forma y color:Solid
    Peso molecular:487.42

    Ref: TM-T1759

  • Bikinin
    Targetmol
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    Bikinin

    CAS:
    <p>Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.</p>
    Fórmula:C9H9BrN2O3
    Pureza:99.86% - >99.99%
    Forma y color:Solid
    Peso molecular:273.08

    Ref: TM-T1965

  • Tyrphostin AG 528
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    Tyrphostin AG 528

    CAS:
    <p>Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).</p>
    Fórmula:C18H14N2O3
    Pureza:99.64%
    Forma y color:Solid
    Peso molecular:306.32

    Ref: TM-T4528

  • Eganelisib
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    Eganelisib

    CAS:
    <p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and &gt;8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>
    Fórmula:C30H24N8O2
    Pureza:99.04% - 99.28%
    Forma y color:Solid
    Peso molecular:528.56

    Ref: TM-T5432

  • Epitinib
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    Epitinib

    CAS:
    <p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>
    Fórmula:C24H26N6O2
    Forma y color:Solid
    Peso molecular:430.5

    Ref: TM-T62397

  • AMG 511
    Targetmol
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    AMG 511

    CAS:
    <p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>
    Fórmula:C22H28FN9O3S
    Pureza:≥98%
    Forma y color:Solid
    Peso molecular:517.58

    Ref: TM-T14214

  • PD153035 hydrochloride
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    PD153035 hydrochloride

    CAS:
    <p>PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR; few influence against FGFR, PGDFR, InsR, CSF-1, and Src.</p>
    Fórmula:C16H15BrClN3O2
    Pureza:99.39% - ≥95%
    Forma y color:Solid
    Peso molecular:396.67

    Ref: TM-T1761

  • PI-103
    Targetmol
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    PI-103

    CAS:
    <p>PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).</p>
    Fórmula:C19H16N4O3
    Pureza:97.79% - 99.3%
    Forma y color:Solid
    Peso molecular:348.36

    Ref: TM-T6143

  • Gefitinib-based PROTAC 3
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    Gefitinib-based PROTAC 3

    CAS:
    <p>Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).</p>
    Fórmula:C47H57ClFN7O8S
    Pureza:97.29% - 98.25%
    Forma y color:Solid
    Peso molecular:934.51

    Ref: TM-T5437

  • ZM39923 hydrochloride
    Targetmol
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    ZM39923 hydrochloride

    CAS:
    <p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>
    Fórmula:C23H25NO·HCl
    Pureza:98.05%
    Forma y color:Solid
    Peso molecular:367.91

    Ref: TM-T6145

  • A66
    Targetmol
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    A66

    CAS:
    <p>A66 is a specific and effective p110α inhibitor(IC50=32 nM).</p>
    Fórmula:C17H23N5O2S2
    Pureza:99.51% - ≥95%
    Forma y color:Solid
    Peso molecular:393.53

    Ref: TM-T2418