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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • PIK-294
    Targetmol
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    PIK-294

    CAS:
    <p>PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).</p>
    Fórmula:C28H23N7O2
    Pureza:97.22% - >99.99%
    Forma y color:Solid
    Peso molecular:489.53

    Ref: TM-T2297

  • Buformin hydrochloride
    Targetmol
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    Buformin hydrochloride

    CAS:
    <p>Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.</p>
    Fórmula:C6H16ClN5
    Pureza:97.83%
    Forma y color:Solid
    Peso molecular:193.68

    Ref: TM-T20029

  • FIIN-3
    Targetmol
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    FIIN-3

    CAS:
    <p>FIIN-3 is an irreversible inhibitor of FGFR.</p>
    Fórmula:C34H36Cl2N8O4
    Pureza:97.63% - 98.92%
    Forma y color:Solid
    Peso molecular:691.61

    Ref: TM-T3466

  • WZ8040
    Targetmol
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    WZ8040

    CAS:
    <p>WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).</p>
    Fórmula:C24H25ClN6OS
    Pureza:97.42% - 99.785%
    Forma y color:Solid
    Peso molecular:481.01

    Ref: TM-T6734

  • PD153035 hydrochloride
    Targetmol
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    PD153035 hydrochloride

    CAS:
    <p>PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR; few influence against FGFR, PGDFR, InsR, CSF-1, and Src.</p>
    Fórmula:C16H15BrClN3O2
    Pureza:99.39% - ≥95%
    Forma y color:Solid
    Peso molecular:396.67

    Ref: TM-T1761

  • Eganelisib
    Targetmol
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    Eganelisib

    CAS:
    <p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and &gt;8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>
    Fórmula:C30H24N8O2
    Pureza:99.04% - 99.28%
    Forma y color:Solid
    Peso molecular:528.56

    Ref: TM-T5432

  • AMG 511
    Targetmol
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    AMG 511

    CAS:
    <p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>
    Fórmula:C22H28FN9O3S
    Pureza:≥98%
    Forma y color:Solid
    Peso molecular:517.58

    Ref: TM-T14214

  • ZM39923 hydrochloride
    Targetmol
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    ZM39923 hydrochloride

    CAS:
    <p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>
    Fórmula:C23H25NO·HCl
    Pureza:98.05%
    Forma y color:Solid
    Peso molecular:367.91

    Ref: TM-T6145

  • SB 216763
    Targetmol
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    SB 216763

    CAS:
    <p>SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).</p>
    Fórmula:C19H12Cl2N2O2
    Pureza:98.9% - 99.13%
    Forma y color:Solid
    Peso molecular:371.22

    Ref: TM-T3077

  • WZ4003
    Targetmol
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    WZ4003

    CAS:
    <p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>
    Fórmula:C25H29ClN6O3
    Pureza:99.65% - >99.99%
    Forma y color:Solid
    Peso molecular:496.99

    Ref: TM-T6291

  • SU5214
    Targetmol
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    SU5214

    CAS:
    <p>SU5214 is a modulator of tyrosine kinase signal transduction.</p>
    Fórmula:C16H13NO2
    Pureza:99.45% - 99.55%
    Forma y color:Solid
    Peso molecular:251.28

    Ref: TM-T3569

  • EAI045
    Targetmol
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    EAI045

    CAS:
    <p>EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.</p>
    Fórmula:C19H14FN3O3S
    Pureza:98.00% - 99.12%
    Forma y color:Solid
    Peso molecular:383.4

    Ref: TM-T6824

  • iMDK
    Targetmol
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    iMDK

    CAS:
    <p>iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.</p>
    Fórmula:C21H13FN2O2S
    Pureza:99.99%
    Forma y color:Solid
    Peso molecular:376.4

    Ref: TM-T9460

  • Vps34-PIK-III
    Targetmol
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    Vps34-PIK-III

    CAS:
    <p>Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.</p>
    Fórmula:C17H17N7
    Pureza:98.39% - 98.43%
    Forma y color:Solid
    Peso molecular:319.36

    Ref: TM-T6945

  • Chrysophanol
    Targetmol
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    Chrysophanol

    CAS:
    <p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>
    Fórmula:C15H10O4
    Pureza:99.44% - 99.91%
    Forma y color:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°C
    Peso molecular:254.24

    Ref: TM-T2995

  • Indirubin-3'-monoxime
    Targetmol
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    Indirubin-3'-monoxime

    CAS:
    <p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>
    Fórmula:C16H11N3O2
    Pureza:99.55%
    Forma y color:Dark Red Solid
    Peso molecular:277.28

    Ref: TM-T5200

  • MK-3903
    Targetmol
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    MK-3903

    CAS:
    <p>MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).</p>
    Fórmula:C27H19ClN2O3
    Pureza:98.63% - 99.75%
    Forma y color:Solid
    Peso molecular:454.9

    Ref: TM-T5187

  • SYR127063
    Targetmol
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    SYR127063

    CAS:
    <p>SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.</p>
    Fórmula:C23H20ClF3N4O3
    Pureza:98.57%
    Forma y color:Solid
    Peso molecular:492.88

    Ref: TM-T34760

  • CP-724714
    Targetmol
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    CP-724714

    CAS:
    <p>CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), &gt;640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2</p>
    Fórmula:C27H27N5O3
    Pureza:97.1% - 98.82%
    Forma y color:Solid
    Peso molecular:469.54

    Ref: TM-T4014

  • CP21R7
    Targetmol
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    CP21R7

    CAS:
    <p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>
    Fórmula:C19H15N3O2
    Pureza:96.14% - 99.16%
    Forma y color:Solid
    Peso molecular:317.34

    Ref: TM-T3684