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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1037 productos de "Señalización PI3K / Akt / mTOR"

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  • GNE-477
    Targetmol
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    GNE-477

    CAS:
    <p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>
    Fórmula:C21H28N8O3S2
    Pureza:98.88% - 99.55%
    Forma y color:Solid
    Peso molecular:504.63

    Ref: TM-T3692

  • O-304
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    O-304

    CAS:
    <p>O-304 is a pan-activator of AMP-activated protein kinase (AMPK).</p>
    Fórmula:C16H11Cl2N3O2S
    Pureza:99.84% - ≥98%
    Forma y color:Solid
    Peso molecular:380.25

    Ref: TM-T7362

  • TG 100713
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    TG 100713

    CAS:
    <p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>
    Fórmula:C12H10N6O
    Pureza:98.17%
    Forma y color:Solid
    Peso molecular:254.25

    Ref: TM-T6704

  • BEBT-908
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    BEBT-908

    CAS:
    <p>BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 &lt;0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).</p>
    Fórmula:C23H25N9O3S
    Pureza:99.67%
    Forma y color:Solid
    Peso molecular:507.57

    Ref: TM-T16529

  • PI3K-IN-1
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    PI3K-IN-1

    CAS:
    <p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>
    Fórmula:C31H29N5O6S
    Pureza:97.03% - 98%
    Forma y color:Solid
    Peso molecular:599.66

    Ref: TM-T1826

  • Dorsomorphin dihydrochloride
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    Dorsomorphin dihydrochloride

    CAS:
    <p>Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on</p>
    Fórmula:C24H25N5O·2HCl
    Pureza:97.74% - 99.89%
    Forma y color:Solid
    Peso molecular:472.41

    Ref: TM-T6146

  • VP3.15 dihydrobromide
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    VP3.15 dihydrobromide

    CAS:
    <p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>
    Fórmula:C20H24Br2N4OS
    Pureza:99.67% - ≥95%
    Forma y color:Solid
    Peso molecular:528.3

    Ref: TM-T5956

  • MHY1485
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    MHY1485

    CAS:
    <p>MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.</p>
    Fórmula:C17H21N7O4
    Pureza:97.74% - >99.99%
    Forma y color:Solid
    Peso molecular:387.39

    Ref: TM-T1908

  • PS 48
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    PS 48

    CAS:
    <p>PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).</p>
    Fórmula:C17H15ClO2
    Pureza:99.96% - ≥95%
    Forma y color:Solid
    Peso molecular:286.75

    Ref: TM-T3163

  • mTOR inhibitor-1
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    mTOR inhibitor-1

    CAS:
    <p>C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.</p>
    Fórmula:C16H15BrN2O3
    Pureza:99.43%
    Forma y color:Solid
    Peso molecular:363.21

    Ref: TM-T5338

  • Epidermal Growth Factor
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    Epidermal Growth Factor

    CAS:
    <p>EGF binds EGFR, promotes cell growth &amp; heals diabetic foot ulcers.</p>
    Fórmula:C270H401N73O83S7
    Pureza:97.17%
    Forma y color:Solid
    Peso molecular:6222

    Ref: TM-T8679

  • lavendustin C
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    lavendustin C

    CAS:
    <p>lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.</p>
    Fórmula:C14H13NO5
    Pureza:98.06%
    Forma y color:Yellow To Tan Powder
    Peso molecular:275.26

    Ref: TM-T4185

  • Canertinib
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    Canertinib

    CAS:
    <p>Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.</p>
    Fórmula:C24H25ClFN5O3
    Pureza:98% - >99.99%
    Forma y color:White Or Similar To White Crystalline Powder
    Peso molecular:485.94

    Ref: TM-T6136

  • Tyrphostin 23
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    Tyrphostin 23

    CAS:
    <p>Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.</p>
    Fórmula:C10H6N2O2
    Pureza:99.7% - 99.86%
    Forma y color:Yellow-Tan Solid
    Peso molecular:186.17

    Ref: TM-T2063

  • AS-605240
    Targetmol
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    AS-605240

    CAS:
    <p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>
    Fórmula:C12H7N3O2S
    Pureza:97% - 99.91%
    Forma y color:Solid
    Peso molecular:257.27

    Ref: TM-T2248

  • Tyrphostin AG 879
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    Tyrphostin AG 879

    CAS:
    <p>Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.</p>
    Fórmula:C18H24N2OS
    Pureza:99.05%
    Forma y color:Solid
    Peso molecular:316.46

    Ref: TM-T6712

  • EGFR-IN-12
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    EGFR-IN-12

    CAS:
    <p>EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.</p>
    Fórmula:C21H18F3N5O
    Pureza:98.3% - 99.76%
    Forma y color:Solid
    Peso molecular:413.4

    Ref: TM-T5168

  • Serabelisib
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    Serabelisib

    CAS:
    <p>Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).</p>
    Fórmula:C19H17N5O3
    Pureza:98.41% - 99.5%
    Forma y color:Solid
    Peso molecular:363.37

    Ref: TM-T3153

  • PS210
    Targetmol
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    PS210

    CAS:
    <p>PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits PDK1-mediated S6K phosphorylation.</p>
    Fórmula:C19H15F3O5
    Pureza:99.78%
    Forma y color:Solid
    Peso molecular:380.31

    Ref: TM-T16670

  • PD168393
    Targetmol
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    PD168393

    CAS:
    <p>PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.</p>
    Fórmula:C17H13BrN4O
    Pureza:99.13% - 99.83%
    Forma y color:Solid
    Peso molecular:369.22

    Ref: TM-T6932