Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1037 productos de "Señalización PI3K / Akt / mTOR"

Pureza (%)

100

productos por página.

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TG100-115
CAS:
- 677297-51-7
TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.
Fórmula:C₁₈H₁₄N₆O₂
Pureza:99.22% - 99.26%
Forma y color:Solid
Peso molecular:346.34
Ref: TM-T2672
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NS309
CAS:
- 18711-16-5
NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.
Fórmula:C₈H₄Cl₂N₂O₂
Pureza:97.55%
Forma y color:Solid
Peso molecular:231.04
Ref: TM-T4612
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Cetuximab
CAS:
- 205923-56-4
Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).
Fórmula:C₁₀₇H₁₇₉N₃₅O₃₆S₇
Pureza:95 - 98.60%
Forma y color:Liquid
Peso molecular:152 kDa
Ref: TM-T9905
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ONO-7475
CAS:
- 1646839-59-9
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
Fórmula:C₃₂H₂₆N₄O₆
Pureza:98.74%
Forma y color:Solid
Peso molecular:562.57
Ref: TM-T8327
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WH-4-025
CAS:
- 1876463-35-2
WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
Fórmula:C₃₉H₃₈F₃N₇O₅
Pureza:99.41%
Forma y color:Solid
Peso molecular:741.76
Ref: TM-T9219
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Methyl 2,5-dihydroxycinnamate
CAS:
- 63177-57-1
Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.
Fórmula:C₁₀H₁₀O₄
Pureza:99.60%
Forma y color:Crystalline
Peso molecular:194.18
Ref: TM-T22974
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PS47
CAS:
- 1180676-33-8
PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.
Fórmula:C₁₇H₁₅ClO₂
Pureza:99.09%
Forma y color:Solid
Peso molecular:286.75
Ref: TM-T24677
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PIK-293
CAS:
- 900185-01-5
PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.
Fórmula:C₂₂H₁₉N₇O
Pureza:99.88%
Forma y color:Solid
Peso molecular:397.43
Ref: TM-T3348
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ALK-IN-1
CAS:
- 1197958-12-5
ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.
Fórmula:C₂₆H₃₄ClN₆O₂P
Pureza:99.74% - 99.80%
Forma y color:Solid
Peso molecular:529.01
Ref: TM-T3059
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ETP-45658
CAS:
- 1198357-79-7
ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).
Fórmula:C₁₆H₁₇N₅O₂
Pureza:99.14%
Forma y color:Solid
Peso molecular:311.34
Ref: TM-T25399
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Zorifertinib
CAS:
- 1626387-80-1
Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.
Fórmula:C₂₂H₂₃ClFN₅O₃
Pureza:98.20% - 99.36%
Forma y color:White To Off-White Solid
Peso molecular:459.9
Ref: TM-T3659
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MTX-211
CAS:
- 1952236-05-3
MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.
Fórmula:C₂₀H₁₄Cl₂FN₅O₂S
Pureza:97.6% - >99.99%
Forma y color:Solid
Peso molecular:478.33
Ref: TM-T4296
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Desmethyl Erlotinib hydrochloride
CAS:
- 183320-51-6
Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.
Fórmula:C₂₁H₂₁N₃O₄·HCl
Pureza:99.49%
Forma y color:Solid
Peso molecular:415.87
Ref: TM-T6619
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PF-06409577
CAS:
- 1467057-23-3
PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).
Fórmula:C₁₉H₁₆ClNO₃
Pureza:95.17% - 98.21%
Forma y color:Solid
Peso molecular:341.79
Ref: TM-T4427
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R547
CAS:
- 741713-40-6
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.
Fórmula:C₁₈H₂₁F₂N₅O₄S
Pureza:90% - 99.64%
Forma y color:Solid
Peso molecular:441.45
Ref: TM-T6312
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5-Bromoindole
CAS:
- 10075-50-0
5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate
Fórmula:C₈H₆BrN
Pureza:99.99%
Forma y color:White To Beige Crystalline Powder
Peso molecular:196.04
Ref: TM-T7473
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AG-1478
CAS:
- 153436-53-4
AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.
Fórmula:C₁₆H₁₄ClN₃O₂
Pureza:99.03% - 99.71%
Forma y color:Solid
Peso molecular:315.75
Ref: TM-T2047
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AG 555
CAS:
- 133550-34-2
AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.
Fórmula:C₁₉H₁₈N₂O₃
Pureza:98.02% - 99.94%
Forma y color:Solid
Peso molecular:322.36
Ref: TM-T4326
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PF-04802367
CAS:
- 1962178-27-3
PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.
Fórmula:C₁₆H₁₆ClN₅O₃
Pureza:98.76%
Forma y color:Solid
Peso molecular:361.78
Ref: TM-T9611
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DMH-25
CAS:
- 1685280-21-0
DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.
Fórmula:C₁₅H₈Br₃NO₃
Pureza:99.26%
Forma y color:Solid
Peso molecular:489.94
Ref: TM-T8569