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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1037 productos de "Señalización PI3K / Akt / mTOR"

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  • OTSSP167
    Targetmol
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    OTSSP167

    CAS:
    <p>OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.</p>
    Fórmula:C25H28Cl2N4O2
    Pureza:98.22% - 99.47%
    Forma y color:Solid
    Peso molecular:487.42

    Ref: TM-T1759

  • AS-041164
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    AS-041164

    CAS:
    <p>AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.</p>
    Fórmula:C11H7NO4S
    Pureza:99.45%
    Forma y color:Solid
    Peso molecular:249.24

    Ref: TM-T21938

  • Desmethyl Erlotinib
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    Desmethyl Erlotinib

    CAS:
    <p>Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).</p>
    Fórmula:C21H21N3O4
    Pureza:97.92% - 98.62%
    Forma y color:Solid
    Peso molecular:379.41

    Ref: TM-T6328

  • WHI-P258
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    WHI-P258

    CAS:
    <p>WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.</p>
    Fórmula:C16H15N3O2
    Pureza:99.66% - 99.92%
    Forma y color:Solid
    Peso molecular:281.31

    Ref: TM-T2035

  • IC-87114
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    IC-87114

    CAS:
    <p>IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).</p>
    Fórmula:C22H19N7O
    Pureza:99.30% - >99.99%
    Forma y color:Solid
    Peso molecular:397.43

    Ref: TM-T2660

  • PQR620
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    PQR620

    CAS:
    <p>PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.</p>
    Fórmula:C21H25F2N7O2
    Pureza:97.61%
    Forma y color:Solid
    Peso molecular:445.47

    Ref: TM-T5472

  • CC-115
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    CC-115

    CAS:
    <p>CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).</p>
    Fórmula:C16H16N8O
    Pureza:86.79% - 99.01%
    Forma y color:Solid
    Peso molecular:336.35

    Ref: TM-T3541

  • PQR530
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    PQR530

    CAS:
    <p>PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.</p>
    Fórmula:C18H23F2N7O2
    Pureza:99.5%
    Forma y color:Solid
    Peso molecular:407.42

    Ref: TM-T16567

  • EX229
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    EX229

    CAS:
    <p>EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.</p>
    Fórmula:C24H18ClN3O3
    Pureza:99.20% - 99.36%
    Forma y color:Solid
    Peso molecular:431.87

    Ref: TM-TQ0028

  • Olmutinib
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    Olmutinib

    CAS:
    <p>Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.</p>
    Fórmula:C26H26N6O2S
    Pureza:99.63%
    Forma y color:Solid
    Peso molecular:486.59

    Ref: TM-T6918

  • A-769662
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    A-769662

    CAS:
    <p>A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).</p>
    Fórmula:C20H12N2O3S
    Pureza:97.52% - 99.58%
    Forma y color:Solid
    Peso molecular:360.39

    Ref: TM-T2468

  • EBE-A22
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    EBE-A22

    CAS:
    <p>EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.</p>
    Fórmula:C17H16BrN3O2
    Pureza:99.087% - 99.88%
    Forma y color:Solid
    Peso molecular:374.23

    Ref: TM-T3558

  • Tesevatinib
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    Tesevatinib

    CAS:
    <p>Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>
    Fórmula:C24H25Cl2FN4O2
    Pureza:97.89% - 98.66%
    Forma y color:Solid
    Peso molecular:491.39

    Ref: TM-TQ0166

  • YU238259
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    YU238259

    CAS:
    <p>YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.</p>
    Fórmula:C22H22ClN3O4S
    Pureza:99.28% - 99.56%
    Forma y color:Solid
    Peso molecular:459.95

    Ref: TM-T4339

  • Cyasterone
    Targetmol
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    Cyasterone

    CAS:
    <p>Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising</p>
    Fórmula:C29H44O8
    Pureza:99.32% - 99.70%
    Forma y color:Solid
    Peso molecular:520.65

    Ref: TM-T3870

  • KU-0060648
    Targetmol
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    KU-0060648

    CAS:
    <p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>
    Fórmula:C33H34N4O4S
    Pureza:98.75%
    Forma y color:Solid
    Peso molecular:582.71

    Ref: TM-T6557

  • Genistein
    Targetmol
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    Genistein

    CAS:
    <p>Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.</p>
    Fórmula:C15H10O5
    Pureza:98.22% - 99.64%
    Forma y color:Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether Solid
    Peso molecular:270.24

    Ref: TM-T1737

  • Rostafuroxin
    Targetmol
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    Rostafuroxin

    CAS:
    <p>Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.</p>
    Fórmula:C23H34O4
    Pureza:99.08% - >99.99%
    Forma y color:Solid
    Peso molecular:374.51

    Ref: TM-T2621

  • WZ-3146
    Targetmol
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    WZ-3146

    CAS:
    <p>WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).</p>
    Fórmula:C24H25ClN6O2
    Pureza:97.15%
    Forma y color:Solid
    Peso molecular:464.95

    Ref: TM-T6733

  • Almonertinib mesylate
    Targetmol
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    Almonertinib mesylate

    CAS:
    <p>Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.</p>
    Fórmula:C31H39N7O5S
    Pureza:99.92%
    Forma y color:Solid
    Peso molecular:621.75

    Ref: TM-T9865