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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1037 productos de "Señalización PI3K / Akt / mTOR"

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  • Desmethyl-VS-5584
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    Desmethyl-VS-5584

    CAS:
    <p>Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.</p>
    Fórmula:C16H20N8O
    Pureza:>99.99%
    Forma y color:Solid
    Peso molecular:340.38

    Ref: TM-T4199

  • CZC-8004
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    CZC-8004

    CAS:
    <p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>
    Fórmula:C17H16FN5
    Pureza:99.29%
    Forma y color:Solid
    Peso molecular:309.34

    Ref: TM-T7186

  • LY-294002 hydrochloride
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    LY-294002 hydrochloride

    CAS:
    <p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>
    Fórmula:C19H17NO3·HCl
    Pureza:99.95%
    Forma y color:Solid
    Peso molecular:343.81

    Ref: TM-T4079

  • MHY-1685
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    MHY-1685

    CAS:
    <p>MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.</p>
    Fórmula:C11H8N2O4
    Pureza:99.76%
    Forma y color:Solid
    Peso molecular:232.19

    Ref: TM-T40351

  • GSK 3 Inhibitor IX
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    GSK 3 Inhibitor IX

    CAS:
    <p>GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.</p>
    Fórmula:C16H10BrN3O2
    Pureza:98% - 99.72%
    Forma y color:Solid
    Peso molecular:356.17

    Ref: TM-T1917

  • (Rac)-JBJ-04-125-02
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    (Rac)-JBJ-04-125-02

    CAS:
    <p>(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.</p>
    Fórmula:C29H26FN5O3S
    Pureza:97.57%
    Forma y color:Solid
    Peso molecular:543.61

    Ref: TM-T8872

  • TWS119
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    TWS119

    CAS:
    <p>TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation</p>
    Fórmula:C18H14N4O2
    Pureza:98.14% - 99.63%
    Forma y color:Solid
    Peso molecular:318.33

    Ref: TM-T2166

  • Leptomycin B
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    Leptomycin B

    CAS:
    <p>Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.</p>
    Fórmula:C33H48O6
    Pureza:97.10% - 99.04%
    Forma y color:White Crystalline Solid
    Peso molecular:540.73

    Ref: TM-T15735

  • GSK3i XIII
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    GSK3i XIII

    CAS:
    <p>GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.</p>
    Fórmula:C18H19N5
    Pureza:98.87%
    Forma y color:Solid
    Peso molecular:305.38

    Ref: TM-T24111

  • Pilaralisib
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    Pilaralisib

    CAS:
    <p>Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).</p>
    Fórmula:C25H25ClN6O4S
    Pureza:98.51% - 99.61%
    Forma y color:Solid
    Peso molecular:541.02

    Ref: TM-T2365

  • SF2523
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    SF2523

    CAS:
    <p>SF2523 is a highly selective and potent inhibitor.</p>
    Fórmula:C19H17NO5S
    Pureza:99.1% - 99.51%
    Forma y color:Solid
    Peso molecular:371.41

    Ref: TM-T3986

  • DS-7423
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    DS-7423

    CAS:
    <p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>
    Fórmula:C22H27F3N10O2
    Pureza:99.98%
    Forma y color:Solid
    Peso molecular:520.51

    Ref: TM-T36083

  • OTSSP167 hydrochloride
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    OTSSP167 hydrochloride

    CAS:
    <p>OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).</p>
    Fórmula:C25H29Cl3N4O2
    Pureza:99.41%
    Forma y color:Solid
    Peso molecular:523.88

    Ref: TM-T21559

  • Gedatolisib
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    Gedatolisib

    CAS:
    <p>Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling</p>
    Fórmula:C32H41N9O4
    Pureza:98% - 99.36%
    Forma y color:Solid
    Peso molecular:615.73

    Ref: TM-T1970

  • Pelitinib
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    Pelitinib

    CAS:
    <p>Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).</p>
    Fórmula:C24H23ClFN5O2
    Pureza:98.37% - 99.84%
    Forma y color:Off-White Solid
    Peso molecular:467.92

    Ref: TM-T2327

  • CNX-2006
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    CNX-2006

    CAS:
    <p>CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of &lt; 20 nM, with very weak inhibition at wild-type EGFR.</p>
    Fórmula:C26H27F4N7O2
    Pureza:98.85% - 99.16%
    Forma y color:Solid
    Peso molecular:545.53

    Ref: TM-T6008

  • Sapitinib
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    Sapitinib

    CAS:
    <p>Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or</p>
    Fórmula:C23H25ClFN5O3
    Pureza:98.89% - 99.83%
    Forma y color:Solid
    Peso molecular:473.93

    Ref: TM-T6092

  • Mobocertinib
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    Mobocertinib

    CAS:
    <p>Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent</p>
    Fórmula:C32H39N7O4
    Pureza:99.47% - 99.97%
    Forma y color:Solid
    Peso molecular:585.7

    Ref: TM-T8151

  • CUDC-101
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    CUDC-101

    CAS:
    <p>CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.</p>
    Fórmula:C24H26N4O4
    Pureza:95.76% - 99.17%
    Forma y color:Solid
    Peso molecular:434.49

    Ref: TM-T3108

  • Afatinib
    Targetmol
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    Afatinib

    CAS:
    <p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>
    Fórmula:C24H25ClFN5O3
    Pureza:98.56% - 99.9%
    Forma y color:Off-White Solid
    Peso molecular:485.94

    Ref: TM-T21312