Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1037 productos de "Señalización PI3K / Akt / mTOR"

Pureza (%)

100

productos por página.

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PI3K/mTOR Inhibitor-3
CAS:
- 1363338-53-7
PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.
Fórmula:C₂₂H₂₃N₅O
Forma y color:Solid
Peso molecular:373.45
Ref: TM-T61516
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TCS 2002
CAS:
- 1005201-24-0
GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.
Fórmula:C₁₈H₁₄N₂O₃S
Forma y color:Solid
Peso molecular:338.38
Ref: TM-T22157
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PP30
CAS:
- 1092788-09-4
PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.
Fórmula:C₁₈H₁₉N₇OS
Pureza:98%
Forma y color:Solid
Peso molecular:381.45
Ref: TM-T28439
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MS 154N
CAS:
- 2675490-97-6
MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.
Fórmula:C₄₇H₅₆ClFN₈O₈
Forma y color:Solid
Peso molecular:915.45
Ref: TM-T41157
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PI3K/mTOR Inhibitor-9
CAS:
- 1392421-71-4
PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).
Fórmula:C₂₃H₂₇N₇O₂
Forma y color:Solid
Peso molecular:433.51
Ref: TM-T62438
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EGFR-IN-16
CAS:
- 133550-22-8
EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
Fórmula:C₁₆H₁₁NO₃
Pureza:98%
Forma y color:Solid
Peso molecular:265.26
Ref: TM-T8525
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NU-7163
CAS:
- 503468-03-9
NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.
Fórmula:C₁₈H₁₇NO₃
Pureza:98%
Forma y color:Solid
Peso molecular:295.33
Ref: TM-T24559
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EGA
CAS:
- 415687-81-9
EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.
Fórmula:C₁₆H₁₆BrN₃O
Pureza:98% - 99.6%
Forma y color:Solid
Peso molecular:346.22
Ref: TM-T25365
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DS21360717
CAS:
- 2304654-43-9
DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.
Fórmula:C₂₁H₂₃N₇O
Pureza:98%
Forma y color:Solid
Peso molecular:389.45
Ref: TM-T11104
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EGFR-IN-67
CAS:
- 2416924-99-5
EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].
Fórmula:C₁₈H₁₇N₃S
Forma y color:Solid
Peso molecular:307.41
Ref: TM-T60729
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WR23
CAS:
- 1350960-66-5
WR23 is a piperidinylquinoxaline derivative and a phosphoinositide 3-kinase α (PI3Kα) inhibitor.
Fórmula:C₁₉H₁₈BrN₃O₃S
Pureza:98%
Forma y color:Solid
Peso molecular:448.33
Ref: TM-T26332
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LTURM-36
CAS:
- 1879887-94-1
LTURM-36 is a novel inhibitor of PI 3-kinase delta.
Fórmula:C₂₂H₁₈N₂O₃
Pureza:98%
Forma y color:Solid
Peso molecular:358.39
Ref: TM-T27858
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DNA-PK-IN-1
CAS:
- 2663850-40-4
DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.
Fórmula:C₂₃H₂₆N₈O₂
Forma y color:Solid
Peso molecular:446.5
Ref: TM-T62648
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ZDWX-25
CAS:
- 2668297-70-7
ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.
Fórmula:C₁₇H₁₅N₃O₃
Forma y color:Solid
Peso molecular:309.32
Ref: TM-T60748
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MIPS-9922
CAS:
- 1416956-33-6
MIPS-9922: potent PI3Kβ inhibitor; prevents αIIbβ3 activation, platelet adhesion, and ADP-triggered aggregation.
Fórmula:C₂₈H₃₁F₂N₉O₂
Pureza:98%
Forma y color:Solid
Peso molecular:563.6
Ref: TM-T28044
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NVP-CLR457
CAS:
- 1453082-52-4
NVP-CLR457 is an oral pan-class I PI3K inhibitor with dose-dependent antitumor activity.
Fórmula:C₁₈H₂₀F₃N₇O₄
Forma y color:Solid
Peso molecular:455.39
Ref: TM-T62816
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NSC81111
CAS:
- 1678-14-4
NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].
Fórmula:C₁₉H₁₆O₄
Forma y color:Solid
Peso molecular:308.33
Ref: TM-T60734
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JR-AB2-011
CAS:
- 2411853-34-2
JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.
Fórmula:C₁₇H₁₄Cl₂FN₃OS
Pureza:98.33% - 98.33%
Forma y color:Solid
Peso molecular:398.28
Ref: TM-T11728
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Limertinib
CAS:
- 1934259-00-3
Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.
Fórmula:C₂₉H₃₂ClN₇O₂
Pureza:97.44%
Forma y color:Solid
Peso molecular:546.06
Ref: TM-T35897
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PI3K-IN-6
CAS:
- 1842380-77-1
PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).
Fórmula:C₁₇H₁₄Cl₂FN₉O
Pureza:98%
Forma y color:Solid
Peso molecular:450.26
Ref: TM-T12457