Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1037 productos de "Señalización PI3K / Akt / mTOR"

Pureza (%)

100

productos por página.

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GNE-293
CAS:
- 1354955-67-1
GNE-293 is a potent and selective PI3Kδ inhibitor.
Fórmula:C₂₈H₃₆N₈O₄S
Pureza:98%
Forma y color:Solid
Peso molecular:580.7
Ref: TM-T27422
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PI-540
CAS:
- 885616-78-4
PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).
Fórmula:C₂₂H₂₇N₅O₂S
Forma y color:Solid
Peso molecular:425.55
Ref: TM-T68443
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DNA-PK-IN-3
CAS:
- 2734846-19-4
DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.
Fórmula:C₁₉H₁₉N₉O
Forma y color:Solid
Peso molecular:389.41
Ref: TM-T61751
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GLPG3970
CAS:
- 2403733-82-2
GLPG3970, a pioneering inhibitor of SIK2/SIK3, is utilized in the investigation of inflammation and autoimmune diseases.
Fórmula:C₂₅H₂₇F₃N₄O₄
Pureza:99.60% - >99.99%
Forma y color:Solid
Peso molecular:504.5
Ref: TM-T73384
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Nimotuzumab
CAS:
- 828933-51-3
Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).
Pureza:95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)
Forma y color:Liquid
Ref: TM-T9923
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EAI001
CAS:
- 892772-75-7
EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.
Fórmula:C₁₉H₁₅N₃O₂S
Pureza:>99.99%
Forma y color:Solid
Peso molecular:349.41
Ref: TM-T61191
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PI3Kδ/γ-IN-2
CAS:
- 2412195-89-0
PI3Kδ/γ-IN-2 is a potent, orally bioavailable dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 4.3 nM) with potential for use in anti-B-cell malignancy
Fórmula:C₂₅H₂₁ClN₈O
Forma y color:Solid
Peso molecular:484.94
Ref: TM-T63221
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PI3Kγ inhibitor 4
CAS:
- 1821038-80-5
PI3Kγ inhibitor 4 is a selective, potent, orally active PI3Kγ inhibitor (IC50: 40 nM).
Fórmula:C₂₀H₂₄N₄O₄S
Forma y color:Solid
Peso molecular:416.49
Ref: TM-T62165
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EGFR-IN-68
CAS:
- 2416925-03-4
EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.
Fórmula:C₂₄H₂₂N₂O
Forma y color:Solid
Peso molecular:354.44
Ref: TM-T61267
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MRT80
CAS:
- 405221-09-2
MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.
Fórmula:C₁₅H₁₅N₅O
Pureza:98%
Forma y color:Solid
Peso molecular:281.31
Ref: TM-T28108
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mTOR inhibitor-2
CAS:
- 2219323-96-1
mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).
Fórmula:C₂₃H₂₁N₇O
Pureza:98%
Forma y color:Solid
Peso molecular:411.46
Ref: TM-T12124
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SDZ281-977
CAS:
- 150779-71-8
SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.
Fórmula:C₁₈H₂₀O₅
Pureza:99.64%
Forma y color:Solid
Peso molecular:316.35
Ref: TM-T16866
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(E/Z)-CP-724714
CAS:
- 537705-08-1
(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].
Fórmula:C₂₇H₂₇N₅O₃
Pureza:98%
Forma y color:Solid
Peso molecular:469.54
Ref: TM-T6046
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PI3Kα-IN-13
CAS:
- 2955529-67-4
PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,
Fórmula:C₂₁H₁₉N₅O₃
Pureza:98%
Forma y color:Solid
Peso molecular:389.41
Ref: TM-T79685
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PI4KIII β inhibitor 3
CAS:
- 1245319-54-3
PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).
Fórmula:C₂₂H₂₂N₈OS
Pureza:98%
Forma y color:Solid
Peso molecular:446.53
Ref: TM-T12467
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Nemiralisib
CAS:
- 1254036-71-9
Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.
Fórmula:C₂₆H₂₈N₆O
Pureza:99.91%
Forma y color:Solid
Peso molecular:440.54
Ref: TM-T15431
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TGX-155
CAS:
- 351071-90-4
TGX-155 is a selective PI3K inhibitor.
Fórmula:C₂₀H₁₉FN₂O₃
Pureza:98%
Forma y color:Solid
Peso molecular:354.37
Ref: TM-T24874
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AG-183
CAS:
- 122520-90-5
(Z)-Tyrphostin A51, a Z-isomer of Lanoconazole A51, is a strong PTK inhibitor blocking [3 H]taurine release and tyrosyl phosphorylation.
Fórmula:C₁₃H₈N₄O₃
Forma y color:Brown Solid
Peso molecular:268.23
Ref: TM-T21783
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FT-1518
CAS:
- 1313026-58-2
FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.
Fórmula:C₂₀H₂₆N₈O
Pureza:98.34% - 98.80%
Forma y color:Solid
Peso molecular:394.47
Ref: TM-T11328
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CAL-130
CAS:
- 1431697-74-3
CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
Fórmula:C₂₃H₂₂N₈O
Pureza:98%
Forma y color:Solid
Peso molecular:426.47
Ref: TM-T10660