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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1037 productos de "Señalización PI3K / Akt / mTOR"

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  • Tarlox-TKI
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    Tarlox-TKI

    CAS:
    <p>Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.</p>
    Fórmula:C19H18BrClN6O
    Pureza:97.03%
    Forma y color:Solid
    Peso molecular:461.74

    Ref: TM-T11761

  • AZD3458
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    AZD3458

    CAS:
    <p>AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, &lt;4.5, and 6.5 , respectively).</p>
    Fórmula:C20H23N3O4S2
    Forma y color:Solid
    Peso molecular:433.54

    Ref: TM-T12466

  • RV-1729
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    RV-1729

    CAS:
    <p>RV-1729, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, is used potentially for the treatment of asthma.</p>
    Fórmula:C39H39ClN8O5
    Forma y color:Solid
    Peso molecular:735.23

    Ref: TM-T28627

  • BKI-1369
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    BKI-1369

    CAS:
    <p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>
    Fórmula:C23H27N7O
    Forma y color:Solid
    Peso molecular:417.51

    Ref: TM-T10556

  • RTC-5
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    RTC-5

    CAS:
    <p>RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.</p>
    Fórmula:C24H22ClF3N2O3S
    Pureza:98.14%
    Forma y color:Solid
    Peso molecular:510.96

    Ref: TM-T12777

  • CAL-130 Hydrochloride
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    CAL-130 Hydrochloride

    CAS:
    <p>CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>
    Fórmula:C23H23ClN8O
    Forma y color:Solid
    Peso molecular:462.94

    Ref: TM-T10660L

  • EGFR-IN-50
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    EGFR-IN-50

    CAS:
    <p>EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.</p>
    Fórmula:C24H26BrN3O4S2
    Forma y color:Solid
    Peso molecular:564.51

    Ref: TM-T63996

  • JBJ-04-125-02
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    JBJ-04-125-02

    CAS:
    <p>JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.</p>
    Fórmula:C29H26FN5O3S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:543.61

    Ref: TM-T11714

  • NSC114126
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    NSC114126

    CAS:
    <p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Fórmula:C22H20O4
    Forma y color:Solid
    Peso molecular:348.39

    Ref: TM-T61177

  • PIKfyve-IN-2
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    PIKfyve-IN-2

    CAS:
    <p>PIKfyve-IN-2 is a potent inhibitor of the PIKfyve kinase, with potential applications in cancer and autoimmune disorder research [1].</p>
    Fórmula:C22H22N8O
    Forma y color:Solid
    Peso molecular:414.46

    Ref: TM-T79210

  • BRD3731
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    BRD3731

    CAS:
    <p>BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.</p>
    Fórmula:C24H31N3O
    Forma y color:Solid
    Peso molecular:377.52

    Ref: TM-T61578

  • Epertinib
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    Epertinib

    CAS:
    <p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>
    Fórmula:C30H27ClFN5O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:560.02

    Ref: TM-T11213L

  • EGFR-IN-64
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    EGFR-IN-64

    CAS:
    <p>EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.</p>
    Fórmula:C20H21N3O3
    Forma y color:Solid
    Peso molecular:351.4

    Ref: TM-T61225

  • (R)-PS210
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    (R)-PS210

    CAS:
    <p>(R)-PS210, the R enantiomer of PS210 is a substrate-selective allosteric PDK1 activator with an (AC50 of 1.8 μM).</p>
    Fórmula:C19H15F3O5
    Forma y color:Solid
    Peso molecular:380.31

    Ref: TM-T12639

  • GW 583340 dihydrochloride
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    GW 583340 dihydrochloride

    CAS:
    <p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>
    Fórmula:C28H27Cl3FN5O3S2
    Pureza:98.80%
    Forma y color:Solid
    Peso molecular:671.03

    Ref: TM-T22827

  • FD2056
    Targetmol
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    FD2056

    CAS:
    <p>FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.</p>
    Fórmula:C23H17ClN6O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:476.94

    Ref: TM-T79370

  • EGFR-IN-89
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    EGFR-IN-89

    CAS:
    <p>EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against</p>
    Fórmula:C26H31FN8O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:538.64

    Ref: TM-T79775

  • AMPK activator 12
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    AMPK activator 12

    CAS:
    <p>AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.</p>
    Fórmula:C23H24BrNO2
    Pureza:99.55%
    Forma y color:Solid
    Peso molecular:426.35

    Ref: TM-T78791

  • PI5P4Ks-IN-1
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    PI5P4Ks-IN-1

    CAS:
    <p>PI5P4Ks-IN-1 (compound 7) is an active compound which engages PI5P4Kγ[1].</p>
    Fórmula:C20H17N3S
    Forma y color:Solid
    Peso molecular:331.43

    Ref: TM-T60982

  • Antiproliferative agent-34
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    Antiproliferative agent-34

    CAS:
    <p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>
    Fórmula:C27H27N7O5
    Pureza:98%
    Forma y color:Solid
    Peso molecular:529.55

    Ref: TM-T79368