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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1037 productos de "Señalización PI3K / Akt / mTOR"

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  • PIMPC
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    PIMPC

    CAS:
    <p>PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits</p>
    Fórmula:C21H19N5O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:357.41

    Ref: TM-T79693

  • PI3Kγ inhibitor 7
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    PI3Kγ inhibitor 7

    CAS:
    <p>PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].</p>
    Fórmula:C31H25N9O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:555.59

    Ref: TM-T79111

  • EGFR-IN-73
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    EGFR-IN-73

    CAS:
    <p>EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].</p>
    Fórmula:C19H17ClFN3O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:405.81

    Ref: TM-T73165

  • 3F8
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    3F8

    CAS:
    <p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>
    Fórmula:C15H14N2O4
    Pureza:98.14% - 98.25%
    Forma y color:Solid
    Peso molecular:286.28

    Ref: TM-T22180

  • Selatinib
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    Selatinib

    CAS:
    <p>Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.</p>
    Fórmula:C29H26ClFN4O3S
    Pureza:98.00%
    Forma y color:Solid
    Peso molecular:565.06

    Ref: TM-T34602

  • CGP52411
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    CGP52411

    CAS:
    <p>CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).</p>
    Fórmula:C20H15N3O2
    Pureza:99.78%
    Forma y color:Solid
    Peso molecular:329.35

    Ref: TM-T10782

  • BRD0209
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    BRD0209

    CAS:
    <p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>
    Fórmula:C22H25N3O
    Pureza:99.92%
    Forma y color:Solid
    Peso molecular:347.45

    Ref: TM-T26894

  • GSK-3β inhibitor 12
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    GSK-3β inhibitor 12

    CAS:
    <p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>
    Fórmula:C14H13N3OS
    Pureza:98.58%
    Forma y color:Solid
    Peso molecular:271.34

    Ref: TM-T60472

  • PI3K/mTOR Inhibitor-4
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    PI3K/mTOR Inhibitor-4

    CAS:
    <p>Oral PI3K/mTOR Inhibitor-4 targets PI3Kα, γ, δ, mTOR; IC50s: 0.63, 22, 9.2, 13.85 nM. Used in cancer research.</p>
    Fórmula:C27H22FN3O6S
    Forma y color:Solid
    Peso molecular:535.54

    Ref: TM-T63770

  • NVS-PI3-4
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    NVS-PI3-4

    CAS:
    <p>NVS-PI3-4: A selective PI3Kγ inhibitor for research in allergies, inflammation, and cancer.</p>
    Fórmula:C20H26N4O3S
    Forma y color:Solid
    Peso molecular:402.51

    Ref: TM-T36315

  • JNJ28871063 hydrochloride
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    JNJ28871063 hydrochloride

    CAS:
    <p>ErbB receptor family inhibitor</p>
    Fórmula:C24H28Cl2N6O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:519.42

    Ref: TM-T22881

  • TC-G 24
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    TC-G 24

    CAS:
    <p>GSK-3β inhibitor</p>
    Fórmula:C15H11ClN4O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:330.73

    Ref: TM-T23436

  • 18BIOder
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    18BIOder

    CAS:
    18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.
    Fórmula:C9H7ClN2O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:210.62

    Ref: TM-T24969

  • Tyrphostin 51
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    Tyrphostin 51

    CAS:
    <p>Tyrphostin 51 is an effective inhibitor of EGFR kinase.</p>
    Fórmula:C13H8N4O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:268.23

    Ref: TM-T24909

  • (S)-PI3Kα-IN-4
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    (S)-PI3Kα-IN-4

    CAS:
    <p>(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM.</p>
    Fórmula:C25H23ClFN5O5S
    Forma y color:Solid
    Peso molecular:560

    Ref: TM-T35488

  • CHMFL-PI3KD-317
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    CHMFL-PI3KD-317

    CAS:
    <p>CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, &gt;10x selective vs. PI3K isoforms, anti-cancer.</p>
    Fórmula:C21H24ClN5O3S2
    Pureza:99.16%
    Forma y color:Solid
    Peso molecular:494.03

    Ref: TM-T10804

  • MS 39
    Targetmol
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    MS 39

    CAS:
    <p>MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.</p>
    Fórmula:C55H71ClFN9O7S
    Forma y color:Solid
    Peso molecular:1056.72

    Ref: TM-T41156

  • PI3KD/V-IN-01
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    PI3KD/V-IN-01

    CAS:
    <p>PI3KD/V-IN-01 is a potent ATP-competitive PI3Kδ/Vps34 dual inhibitor.</p>
    Fórmula:C21H24ClN5O3S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:494.03

    Ref: TM-T28413

  • AZ2
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    AZ2

    CAS:
    <p>AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.</p>
    Fórmula:C20H23N3O2S
    Pureza:99.25%
    Forma y color:Solid
    Peso molecular:369.48

    Ref: TM-T36309

  • Gefitinib N-oxide
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    Gefitinib N-oxide

    CAS:
    <p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.</p>
    Fórmula:C22H24ClFN4O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:462.9

    Ref: TM-T11385