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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • DBPR112
    Targetmol
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    DBPR112

    CAS:
    <p>DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.</p>
    Fórmula:C32H31N5O3
    Pureza:99.25%
    Forma y color:Solid
    Peso molecular:533.62

    Ref: TM-T10965

  • AM-0687
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    AM-0687

    CAS:
    <p>AM-0687: Strong PI3Kδ blocker; pAKT IC50=0.7nM, u(pAKT) IC50=4.6nM; Rat IgG ED50=0.026mg/kg, IgM ED50=0.016mg/kg; Clu=2.3L/hr/kg.</p>
    Fórmula:C23H19FN8O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:442.45

    Ref: TM-T26607

  • Cazpaullone
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    Cazpaullone

    CAS:
    <p>Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.</p>
    Fórmula:C16H10N4O
    Forma y color:Solid
    Peso molecular:274.28

    Ref: TM-T26959

  • VP3.15
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    VP3.15

    CAS:
    <p>VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).</p>
    Fórmula:C20H22N4OS
    Pureza:98%
    Forma y color:Solid
    Peso molecular:366.48

    Ref: TM-T13310

  • GSK3-IN-2
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    GSK3-IN-2

    CAS:
    <p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>
    Fórmula:C17H19N3OS
    Pureza:98.8%
    Forma y color:Solid
    Peso molecular:313.42

    Ref: TM-T73270

  • Aloisine B
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    Aloisine B

    CAS:
    <p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>
    Fórmula:C15H14ClN3
    Pureza:95.15%
    Forma y color:Solid
    Peso molecular:271.74

    Ref: TM-T69188

  • PI3K/mTOR Inhibitor-2
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    PI3K/mTOR Inhibitor-2

    CAS:
    <p>Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ &amp; mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.</p>
    Fórmula:C20H13ClF2N4O4S
    Pureza:96.16%
    Forma y color:Solid
    Peso molecular:478.86

    Ref: TM-T12459

  • PI3Kdelta inhibitor 1
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    PI3Kdelta inhibitor 1

    CAS:
    <p>PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.</p>
    Fórmula:C27H38N6O5S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:558.69

    Ref: TM-T12461

  • Mutated EGFR-IN-3
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    Mutated EGFR-IN-3

    CAS:
    <p>Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.</p>
    Fórmula:C31H29FN4O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:508.59

    Ref: TM-T12131

  • DNA-PK-IN-4
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    DNA-PK-IN-4

    CAS:
    <p>DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.</p>
    Fórmula:C20H24N6O3
    Forma y color:Solid
    Peso molecular:396.44

    Ref: TM-T61857

  • EGFR/HER2-IN-9
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    EGFR/HER2-IN-9

    CAS:
    <p>EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR</p>
    Fórmula:C25H25ClFN5O4
    Forma y color:Solid
    Peso molecular:513.95

    Ref: TM-T72854

  • Lavendustin C6
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    Lavendustin C6

    CAS:
    <p>Lavendustin C6 is a effective tyrosine kinase inhibitor.</p>
    Fórmula:C20H25NO5
    Forma y color:Solid
    Peso molecular:359.42

    Ref: TM-T25644

  • Nazartinib mesylate
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    Nazartinib mesylate

    CAS:
    <p>Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).</p>
    Fórmula:C27H35ClN6O5S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:591.12

    Ref: TM-T11156L

  • BAY 2476568
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    BAY 2476568

    CAS:
    <p>BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 &lt;0.2 nM) and mutant EGFR (IC50 &lt;0.2 nM).</p>
    Fórmula:C24H27FN4O4
    Forma y color:Solid
    Peso molecular:454.49

    Ref: TM-T62795

  • Leniolisib phosphate
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    Leniolisib phosphate

    CAS:
    <p>Leniolisib phosphate is an effective PI3K inhibitor.</p>
    Fórmula:C21H28F3N6O6P
    Forma y color:Solid
    Peso molecular:548.45

    Ref: TM-T5166L

  • PKI-179
    Targetmol
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    PKI-179

    CAS:
    <p>PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.</p>
    Fórmula:C25H28N8O3
    Forma y color:Solid
    Peso molecular:488.54

    Ref: TM-T36084

  • EGFR-IN-28
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    EGFR-IN-28

    CAS:
    <p>EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .</p>
    Fórmula:C31H39BrN10O3S
    Forma y color:Solid
    Peso molecular:711.68

    Ref: TM-T73105

  • SIKs-IN-1
    Targetmol
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    SIKs-IN-1

    CAS:
    <p>SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2</p>
    Fórmula:C27H31F2N7O
    Forma y color:Solid
    Peso molecular:507.58

    Ref: TM-T78762

  • EGFR-IN-55
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    EGFR-IN-55

    CAS:
    <p>"EGFR-IN-55 targets EGFRWT (70 nM IC50) &amp; EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."</p>
    Fórmula:C25H25Cl2N7O2
    Forma y color:Solid
    Peso molecular:526.42

    Ref: TM-T63693

  • PI3K-IN-36
    Targetmol
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    PI3K-IN-36

    CAS:
    <p>PI3K-IN-36 is a potent inhibitor of PI3K, suitable for research applications in follicular lymphoma (FL).</p>
    Fórmula:C30H36F2N8O
    Forma y color:Solid
    Peso molecular:562.66

    Ref: TM-T73150