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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • PKI-179 hydrochloride
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    PKI-179 hydrochloride

    CAS:
    <p>PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.</p>
    Fórmula:C25H29ClN8O3
    Forma y color:Solid
    Peso molecular:525

    Ref: TM-T36085

  • PI3K-IN-28
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    PI3K-IN-28

    CAS:
    <p>PI3K-IN-28, a potent PI3K inhibitor with low toxicity in MCF-10a, has IC50 values of 5.8, 2.3, 7.9 μM and high selectivity index of 39.</p>
    Fórmula:C26H16F9N3O3S2
    Forma y color:Solid
    Peso molecular:653.54

    Ref: TM-T73118

  • DNA-PK-IN-5
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    DNA-PK-IN-5

    CAS:
    <p>DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.</p>
    Fórmula:C21H22N8O2
    Forma y color:Solid
    Peso molecular:418.45

    Ref: TM-T62191

  • CAY10717
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    CAY10717

    CAS:
    <p>CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.</p>
    Fórmula:C29H25F3N6O3
    Forma y color:Solid
    Peso molecular:562.54

    Ref: TM-T36193

  • UNC-CA359
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    UNC-CA359

    CAS:
    <p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>
    Fórmula:C18H14ClN3O2
    Forma y color:Solid
    Peso molecular:339.78

    Ref: TM-T61077

  • EGFR-IN-75
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    EGFR-IN-75

    <p>EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.</p>
    Fórmula:C10H6N6S2
    Forma y color:Solid
    Peso molecular:274.32

    Ref: TM-T73178

  • PI3Kα-IN-4
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    PI3Kα-IN-4

    CAS:
    <p>PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1].</p>
    Fórmula:C25H23ClFN5O5S
    Forma y color:Solid
    Peso molecular:560

    Ref: TM-T35527

  • (E/Z)-AG490
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    (E/Z)-AG490

    CAS:
    <p>(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.</p>
    Fórmula:C17H14N2O3
    Forma y color:Solid
    Peso molecular:294.3

    Ref: TM-T60624

  • EGFR-IN-49
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    EGFR-IN-49

    CAS:
    <p>EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) &amp; T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.</p>
    Fórmula:C22H15N5O2S
    Forma y color:Solid
    Peso molecular:413.45

    Ref: TM-T62113

  • PD 173955-Analog1
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    PD 173955-Analog1

    CAS:
    <p>PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.</p>
    Fórmula:C21H14Cl2N4O3
    Forma y color:Solid
    Peso molecular:441.27

    Ref: TM-T71912

  • PI3K-IN-2
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    PI3K-IN-2

    CAS:
    <p>PI3K-IN-2 inhibits PI3Kβ/δ (IC50: 7.1, 8.6 nM) with greater selectivity over PI3Kσ/γ (IC50: 13, 190 nM) and is orally active.</p>
    Fórmula:C28H29F2N3O5
    Forma y color:Solid
    Peso molecular:525.54

    Ref: TM-T63682

  • EGFR/HER2-IN-3
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    EGFR/HER2-IN-3

    CAS:
    <p>EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.</p>
    Fórmula:C26H23N5O3
    Forma y color:Solid
    Peso molecular:453.49

    Ref: TM-T62777

  • NVP-BBD130
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    NVP-BBD130

    CAS:
    <p>NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.</p>
    Fórmula:C28H21N5O
    Forma y color:Solid
    Peso molecular:443.5

    Ref: TM-T62603

  • eCF-309
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    eCF-309

    CAS:
    <p>eCF-309 is a potent mTOR inhibitor with IC50 value of 15 nM.</p>
    Fórmula:C18H21N7O3
    Forma y color:Solid
    Peso molecular:383.4

    Ref: TM-T27236

  • DNA-PK-IN-7
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    DNA-PK-IN-7

    CAS:
    <p>DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).</p>
    Fórmula:C19H21N9O2
    Forma y color:Solid
    Peso molecular:407.43

    Ref: TM-T62034

  • PDZ1i
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    PDZ1i

    CAS:
    <p>PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.</p>
    Fórmula:C28H26N8O4
    Forma y color:Solid
    Peso molecular:538.56

    Ref: TM-T63797

  • BIBX 1382 Dihydrochloride
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    BIBX 1382 Dihydrochloride

    CAS:
    <p>BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.</p>
    Fórmula:C18H21Cl3FN7
    Forma y color:Solid
    Peso molecular:460.76

    Ref: TM-T30443

  • EGFR-IN-31
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    EGFR-IN-31

    CAS:
    <p>EGFR-IN-31: Potent EGFR inhibitor, targets mutations &amp; overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)</p>
    Fórmula:C32H36FN7O2
    Forma y color:Solid
    Peso molecular:569.67

    Ref: TM-T64030

  • LDC0496
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    LDC0496

    CAS:
    <p>LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.</p>
    Fórmula:C32H35N5O3
    Forma y color:Solid
    Peso molecular:537.65

    Ref: TM-T63792

  • EGFR-IN-69
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    EGFR-IN-69

    CAS:
    <p>EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.</p>
    Fórmula:C31H37Cl2N7O3S
    Forma y color:Solid
    Peso molecular:658.64

    Ref: TM-T73153