gsk-3
Los inhibidores de GSK-3 son compuestos que inhiben la Glicógeno Sintasa Quinasa 3 (GSK-3), una enzima involucrada en numerosos procesos celulares, como el metabolismo del glucógeno, la transcripción génica y la proliferación celular. GSK-3 está implicada en diversas enfermedades, como la diabetes, los trastornos neurodegenerativos y el cáncer. Los inhibidores de GSK-3 son herramientas importantes para explorar estas vías y desarrollar posibles terapias. En CymitQuimica, ofrecemos inhibidores de GSK-3 para apoyar su investigación en enfermedades metabólicas, neurobiología y oncología.
Se han encontrado 110 productos de "gsk-3"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
PROTAC GSK-3β Degrader-1
PROTACGSK-3β Degrader-1 (compound 1) is a degrader targeting GSK-3β with an IC50 of 833 nM. This compound consists of SB-216763 (a GSK-3β inhibitor), a PEG linker, and CRBN (E3 ligase ligand). It reduces neurotoxicity induced by Aβ25-35 peptide and CuSO4 and is applicable in Alzheimer's disease research.Fórmula:C43H42Cl2N6O9Peso molecular:856.239032B-(SP)
CAS:Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)Fórmula:C71H123N26O29PPureza:98%Forma y color:SolidPeso molecular:1835.87GSK3-IN-1
CAS:GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.
Fórmula:C14H10ClN3OSPureza:99.66%Forma y color:SolidPeso molecular:303.77GSK-3β inhibitor 1
CAS:GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.Fórmula:C14H10N2OPureza:99.40%Forma y color:SolidPeso molecular:222.24Ref: TM-T11467
1mg64,00€5mg137,00€10mg210,00€25mg376,00€50mg567,00€100mg777,00€200mg1.026,00€1mL*10mM (DMSO)150,00€GSK-3 inhibitor 3
CAS:GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectivelyFórmula:C23H15FN6OPureza:99.89%Forma y color:SoildPeso molecular:410.4GSK-3β inhibitor 22
CAS:GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.Fórmula:C18H12F3N3O2S2Forma y color:SolidPeso molecular:423.43GSK-3β inhibitor 19
GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.Fórmula:C15H12N4O2SForma y color:SolidPeso molecular:312.35GSK-3 Inhibitor 5
CAS:4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.
Fórmula:C9H6BrNOPureza:99.58%Forma y color:Off-White To Light Yellow Crystalline PowderPeso molecular:224.05MeBIO
CAS:MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Fórmula:C17H12BrN3O2Pureza:99.64%Forma y color:SolidPeso molecular:370.2Ref: TM-T21966
1mg39,00€5mg74,00€10mg117,00€25mg220,00€50mg354,00€100mg520,00€500mg1.130,00€1mL*10mM (DMSO)86,00€CHIR-98023
CAS:CHIR-98023 is a bio-active chemical.Fórmula:C20H16Cl2N8O2Forma y color:SolidPeso molecular:471.30yGsy2p-IN-H23
CAS:yGsy2p-IN-H23 targets yeast GSY2 with IC50 of 875μM for hGYS1, for GSD research.Fórmula:C23H27N3O2Forma y color:SolidPeso molecular:377.488BIO-acetoxime
CAS:BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
Fórmula:C18H12BrN3O3Pureza:97.15%Forma y color:SolidPeso molecular:398.21Bikinin
CAS:Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.
Fórmula:C9H9BrN2O3Pureza:99.86% - >99.99%Forma y color:SolidPeso molecular:273.08SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Fórmula:C16H10ClN3O5Pureza:99.55%Forma y color:SolidPeso molecular:359.72KY19382
CAS:KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Fórmula:C17H11Cl2N3O2Pureza:98.06%Forma y color:SolidPeso molecular:360.19Ref: TM-T9025
1mg94,00€5mg187,00€10mg333,00€25mg560,00€50mg797,00€100mg1.071,00€500mg2.187,00€1mL*10mM (DMSO)230,00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Forma y color:SolidPeso molecular:528.3AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Fórmula:C19H18N4O2Pureza:97.72% - 99.75%Forma y color:SolidPeso molecular:334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€TDZD-8
CAS:TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.Fórmula:C10H10N2O2SPureza:97.13% - 99.61%Forma y color:White SolidPeso molecular:222.26Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Fórmula:C16H11N3O2Pureza:98.34%Forma y color:SolidPeso molecular:277.28GSK-3β inhibitor 10
CAS:GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.Fórmula:C12H12N2O3SPureza:98.06%Forma y color:SolidPeso molecular:264.3
