gsk-3
Los inhibidores de GSK-3 son compuestos que inhiben la Glicógeno Sintasa Quinasa 3 (GSK-3), una enzima involucrada en numerosos procesos celulares, como el metabolismo del glucógeno, la transcripción génica y la proliferación celular. GSK-3 está implicada en diversas enfermedades, como la diabetes, los trastornos neurodegenerativos y el cáncer. Los inhibidores de GSK-3 son herramientas importantes para explorar estas vías y desarrollar posibles terapias. En CymitQuimica, ofrecemos inhibidores de GSK-3 para apoyar su investigación en enfermedades metabólicas, neurobiología y oncología.
Se han encontrado 107 productos para "gsk-3".
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CHIR 98024
CAS:CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Fórmula:C20H17Cl2N9O2Pureza:99.45%Forma y color:SolidPeso molecular:486.31Ref: TM-T3074
1mg42,00€2mg52,00€5mg90,00€1mL*10mM (DMSO)92,00€10mg144,00€25mg281,00€50mg462,00€100mg668,00€1-Azakenpaullone
CAS:1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.Fórmula:C15H10BrN3OPureza:99.73%Forma y color:Yellow SolidPeso molecular:328.16Ref: TM-T6358
1mg74,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg439,00€50mg620,00€100mg888,00€200mg1.198,00€GSK3-IN-3
CAS:GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.Fórmula:C24H35N3O4Pureza:98.16%Forma y color:SolidPeso molecular:429.55GSK3-IN-2
CAS:GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.Fórmula:C17H19N3OSPureza:99.51%Forma y color:SolidPeso molecular:313.42MRT80
CAS:MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.Fórmula:C15H15N5OPureza:98%Forma y color:SolidPeso molecular:281.31TCS 2002
CAS:GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.Fórmula:C18H14N2O3SForma y color:SolidPeso molecular:338.38ZDWX-25
CAS:ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.Fórmula:C17H15N3O3Forma y color:SolidPeso molecular:309.3218BIOder
CAS:18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.Fórmula:C9H7ClN2O2Pureza:98%Forma y color:SolidPeso molecular:210.62BRD3731
CAS:BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.Fórmula:C24H31N3OForma y color:SolidPeso molecular:377.523F8
CAS:3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used inFórmula:C15H14N2O4Pureza:98.17% - 98.25%Forma y color:Yellow SolidPeso molecular:286.28GSK-3β inhibitor 23
CAS:GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.Fórmula:C18H13Cl2N5O2SForma y color:SolidPeso molecular:434.299VP3.15
CAS:VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).Fórmula:C20H22N4OSPureza:98%Forma y color:SolidPeso molecular:366.48GSK-3β inhibitor 24
GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.Fórmula:C26H18N4O3Forma y color:SolidPeso molecular:434.446Cazpaullone
CAS:Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.Fórmula:C16H10N4OForma y color:SolidPeso molecular:274.28BRD1652
CAS:BRD1652 is a highly selective and potent GSK3 inhibitor.Fórmula:C20H20F3N3OPureza:98%Forma y color:SolidPeso molecular:375.39PfGSK3/PfPK6-IN-2
CAS:PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.Fórmula:C24H25Cl2N5OSForma y color:SolidPeso molecular:502.46TWS-119 TFA
CAS:TWS-119 is a GSK-3β inhibitor; activates Wnt/β-catenin to induce differentiation; enhances T-cell antitumor activity and protects BBB.Fórmula:C22H16F6N4O6Pureza:99.65%Forma y color:White SolidPeso molecular:546.38PIMPC
CAS:PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFórmula:C21H19N5OPureza:98%Forma y color:SolidPeso molecular:357.41BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.Fórmula:C22H25N3OPureza:99.92%Forma y color:SolidPeso molecular:347.45
