AMPK
Los inhibidores de AMPK son compuestos que inhiben la Proteína Quinasa Activada por AMP (AMPK), una enzima clave en la homeostasis energética celular. La AMPK se activa en respuesta a bajos niveles de energía en las células y regula procesos como la captación de glucosa, la oxidación de ácidos grasos y la biogénesis mitocondrial. Inhibir la AMPK es fundamental para estudiar su papel en enfermedades metabólicas, cáncer y envejecimiento. En CymitQuimica, ofrecemos una variedad de inhibidores de AMPK para apoyar su investigación en metabolismo, oncología y enfermedades relacionadas con la edad.
Se han encontrado 160 productos para "AMPK".
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ASP4132
CAS:ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.Fórmula:C46H51F3N6O8S2Pureza:98.34%Forma y color:SolidPeso molecular:937.06Ref: TM-T8432
1mg50,00€5mg114,00€10mg177,00€1mL*10mM (DMSO)185,00€25mg321,00€50mg482,00€100mg677,00€200mg928,00€HTH-01-015
CAS:HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).Fórmula:C26H28N8OPureza:98.38% - 99.70%Forma y color:Yellow SolidPeso molecular:468.55Ref: TM-T2374
1mg42,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg101,00€25mg200,00€50mg286,00€100mg385,00€Buformin hydrochloride
CAS:Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Fórmula:C6H16ClN5Pureza:97.83%Forma y color:SolidPeso molecular:193.68PF-06409577
CAS:PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).Fórmula:C19H16ClNO3Pureza:95.17% - 98.21%Forma y color:SolidPeso molecular:341.79Ref: TM-T4427
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)71,00€10mg100,00€25mg200,00€50mg334,00€100mg537,00€200mg762,00€7-Methoxyisoflavone
CAS:7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).Fórmula:C16H12O3Pureza:99.93% - 99.94%Forma y color:White SolidPeso molecular:252.26Methyl cinnamate
CAS:Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.Fórmula:C10H10O2Pureza:99.88%Forma y color:White SolidPeso molecular:162.19Cimiracemoside C
CAS:Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.Fórmula:C35H56O9Pureza:99.95%Forma y color:SolidPeso molecular:620.81Karanjin
CAS:Karanjin, a flavonoid from karanja seeds, boosts GLUT4, AMPK in muscles, and triggers cancer cell apoptosis.Fórmula:C18H12O4Pureza:99.01%Forma y color:SolidPeso molecular:292.29Ref: TM-T2S0820
1mg46,00€1mL*10mM (DMSO)94,00€5mg96,00€10mg145,00€25mg259,00€50mg385,00€100mg557,00€200mg790,00€EX229
CAS:EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.Fórmula:C24H18ClN3O3Pureza:99.20% - 99.36%Forma y color:White SolidPeso molecular:431.87Ref: TM-TQ0028
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)80,00€10mg105,00€25mg210,00€50mg356,00€100mg535,00€A-769662
CAS:A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).Fórmula:C20H12N2O3SPureza:97.52% - 99.58%Forma y color:SolidPeso molecular:360.39Ref: TM-T2468
2mg37,00€5mg54,00€1mL*10mM (DMSO)56,00€10mg74,00€25mg135,00€50mg244,00€100mg440,00€500mg964,00€RGX-202
CAS:RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.Fórmula:C4H9N3O2Pureza:99.67% - 99.8%Forma y color:SolidPeso molecular:131.13Chromium(III) acetate
CAS:Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.Fórmula:C2H3O2CrPureza:99.9%Forma y color:Green SolidPeso molecular:76.37Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Fórmula:C27H29NO11Pureza:99.31% - 99.73%Forma y color:Red Crystalline Solid SolidPeso molecular:543.52Asteltoxin
CAS:Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.Fórmula:C23H30O7Forma y color:SolidPeso molecular:418.486AD1058
CAS:AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.Fórmula:C19H20N6O3SPureza:98.24%Forma y color:Yellow SolidPeso molecular:412.47Ref: TM-T200105
1mg66,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg222,00€25mg447,00€50mg685,00€100mg888,00€TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Fórmula:C21H32O6Pureza:99.21%Forma y color:Yellow SolidPeso molecular:380.48Ref: TM-T13173
1mg75,00€5mg164,00€1mL*10mM (DMSO)167,00€10mg260,00€25mg440,00€50mg620,00€100mg964,00€PF-739
CAS:PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.Fórmula:C23H23ClN2O5Pureza:98%Forma y color:SolidPeso molecular:442.89ULK1-IN-2
CAS:ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.Fórmula:C19H16BrFN4O6Pureza:99.07% - 99.97%Forma y color:SolidPeso molecular:495.26JJO-1
CAS:JJO-1 is a bi-quinoline activating all AMPK αβγ isoforms except γ3; it requires low ATP and is unaffected by γ mutations or β deletions.Fórmula:C19H13N3Forma y color:SolidPeso molecular:283.33XMD-17-51
CAS:XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.Fórmula:C21H24N8OPureza:99.04%Forma y color:SolidPeso molecular:404.47AMPK activator 1
CAS:AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).Fórmula:C32H33F3N4O3Pureza:98%Forma y color:SolidPeso molecular:578.62AMPK activator 9
CAS:AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.Fórmula:C31H28F4N4O4Forma y color:SolidPeso molecular:596.57AMPK activator 12
CAS:AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Fórmula:C23H24BrNO2Pureza:99.57%Forma y color:SolidPeso molecular:426.35SMTIN-T140
CAS:SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Fórmula:C36H34BrClFN5OPPureza:98%Forma y color:SolidPeso molecular:718.02IND 1316
CAS:IND 1316 is an activator of AMP-activated protein kinase (AMPK).Fórmula:C22H17NO3Forma y color:SolidPeso molecular:343.38AMPK activator 8
CAS:AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.Fórmula:C25H21ClN2O6Forma y color:SolidPeso molecular:480.9AMPK activator 11
CAS:AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-Fórmula:C25H20N4O2Pureza:98%Forma y color:SolidPeso molecular:408.45OSU-53
CAS:OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.Fórmula:C25H24F3N3O6S2Forma y color:SolidPeso molecular:583.6AMPK activator 4
CAS:Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.Fórmula:C24H21ClN2O3Pureza:99.97% - 99.99%Forma y color:SolidPeso molecular:420.89Ref: TM-T62238
1mg86,00€5mg173,00€1mL*10mM (DMSO)203,00€10mg334,00€25mg563,00€50mg802,00€100mg1.099,00€500mg2.187,00€LRRK2/NUAK1/TYK2-IN-1
CAS:LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.Fórmula:C20H11F3N6Forma y color:SolidPeso molecular:392.34GL-V9
CAS:GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.Fórmula:C24H27NO5Forma y color:SolidPeso molecular:409.47AMPK activator 6
CAS:AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.Fórmula:C25H28O5Forma y color:SolidPeso molecular:408.49HL271
CAS:HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Fórmula:C13H17ClF3N5OPureza:99.84%Forma y color:SolidPeso molecular:351.76ML753286
CAS:ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Fórmula:C20H25N3O3Pureza:98%Forma y color:SolidPeso molecular:355.43YM-53601 free base
CAS:YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.Fórmula:C21H21FN2OPureza:98%Forma y color:SolidPeso molecular:336.4AMDE-1
CAS:AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.Fórmula:C18H8ClF6N3Pureza:90%Forma y color:SolidPeso molecular:415.72DK419
CAS:DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Fórmula:C16H8ClF6N3OPureza:99.63%Forma y color:White SolidPeso molecular:407.7AMPK-IN-3
CAS:AMPK-IN-3: potent, selective AMPK (α2/α1) & KDR inhibitor; IC50: 60.7/107/3820 nM; anticancer in K562 cells.Fórmula:C25H33N5O3Pureza:97.25%Forma y color:SolidPeso molecular:451.56YLF-466D
CAS:YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Fórmula:C29H20ClNO3Pureza:97.74%Forma y color:SolidPeso molecular:465.93Ref: TM-T13368
1mg34,00€5mg79,00€1mL*10mM (DMSO)82,00€10mg111,00€25mg188,00€50mg269,00€100mg371,00€200mg512,00€PF-249
CAS:PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Fórmula:C17H16ClN3O3Pureza:97.01%Forma y color:SolidPeso molecular:345.78Ref: TM-T24626
1mg46,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg236,00€50mg344,00€100mg482,00€200mg662,00€AMPK-IN-1
CAS:AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Fórmula:C24H18ClN3O3Forma y color:SolidPeso molecular:431.87MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Fórmula:C22H24F2N6O2Pureza:99.47% - >99.99%Forma y color:SolidPeso molecular:442.46AMPK activator 7
CAS:AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.Fórmula:C23H22F3N3O5Forma y color:SolidPeso molecular:477.43PF-06679142
CAS:PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Fórmula:C20H17F2NO3Pureza:98%Forma y color:SolidPeso molecular:357.35MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Fórmula:C18H18ClF2N5OSPureza:98%Forma y color:SolidPeso molecular:425.88Butylate
CAS:Butylate is a herbicide of thiocarbamate.Fórmula:C11H23NOSForma y color:SolidPeso molecular:217.37MARK-IN-1
CAS:MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Fórmula:C22H23F2N7OSPureza:98%Forma y color:SolidPeso molecular:471.53MRT199665
CAS:MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.Fórmula:C28H31N5O2Forma y color:SolidPeso molecular:469.58Ampkinone
CAS:Ampkinone is an indirect AMPK activator.Fórmula:C31H23NO6Pureza:98%Forma y color:SolidPeso molecular:505.52
