PI3K
Los inhibidores de PI3K son compuestos que bloquean la actividad de las fosfoinosítido 3-quinasas (PI3Ks), una familia de enzimas involucradas en una amplia gama de procesos celulares, incluidos el crecimiento, la proliferación, la supervivencia y el metabolismo. La vía PI3K/Akt/mTOR a menudo está desregulada en el cáncer, lo que convierte a PI3K en un objetivo clave para la terapia contra el cáncer. Los inhibidores de PI3K son herramientas fundamentales para estudiar la transducción de señales, la biología del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una variedad de inhibidores de PI3K para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 231 productos de "PI3K"
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Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Fórmula:C17H17N7Pureza:98.39% - 98.43%Forma y color:SolidPeso molecular:319.36Ref: TM-T6945
1mg49,00€2mg67,00€5mg110,00€10mg192,00€25mg429,00€50mg628,00€100mg893,00€500mg1.791,00€1mL*10mM (DMSO)110,00€GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Fórmula:C21H28N8O3S2Pureza:98.88% - 99.55%Forma y color:SolidPeso molecular:504.63Ref: TM-T3692
1mg44,00€2mg57,00€5mg93,00€10mg138,00€25mg286,00€50mg447,00€100mg677,00€1mL*10mM (DMSO)92,00€TG 100713
CAS:TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.
Fórmula:C12H10N6OPureza:98.17%Forma y color:SolidPeso molecular:254.25BEBT-908
CAS:BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).Fórmula:C23H25N9O3SPureza:99.67%Forma y color:SolidPeso molecular:507.57Ref: TM-T16529
1mg94,00€5mg222,00€10mg334,00€25mg562,00€50mg802,00€100mg1.063,00€200mg1.459,00€1mL*10mM (DMSO)249,00€PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Fórmula:C31H29N5O6SPureza:97.03% - 98%Forma y color:SolidPeso molecular:599.661,3-Dicaffeoylquinic acid
CAS:1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.Fórmula:C25H24O12Pureza:98% - 98.81%Forma y color:SolidPeso molecular:516.45Ref: TM-T5736
1mg37,00€5mg71,00€10mg90,00€25mg147,00€50mg208,00€100mg309,00€200mg447,00€1mL*10mM (DMSO)103,00€Euscaphic acid
CAS:Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.Fórmula:C30H48O5Pureza:98.93%Forma y color:SolidPeso molecular:488.7AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Fórmula:C12H7N3O2SPureza:97% - 99.91%Forma y color:SolidPeso molecular:257.27GSK1059615
CAS:GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Fórmula:C18H11N3O2SPureza:99.3% - ≥95%Forma y color:SolidPeso molecular:333.36HS-173
CAS:HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).Fórmula:C21H18N4O4SPureza:99.33% - 99.64%Forma y color:SolidPeso molecular:422.46Ref: TM-T2308
2mg34,00€5mg52,00€10mg77,00€25mg128,00€50mg200,00€100mg296,00€200mg425,00€1mL*10mM (DMSO)52,00€Serabelisib
CAS:Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).Fórmula:C19H17N5O3Pureza:98.41% - 99.5%Forma y color:SolidPeso molecular:363.37TG100-115
CAS:TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.Fórmula:C18H14N6O2Pureza:99.22% - 99.26%Forma y color:SolidPeso molecular:346.34Ref: TM-T2672
1mg40,00€5mg80,00€10mg109,00€25mg200,00€50mg358,00€100mg557,00€500mg1.153,00€1mL*10mM (DMSO)87,00€Sophocarpine
CAS:Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Fórmula:C15H22N2OPureza:99.89%Forma y color:SolidPeso molecular:246.35Quercetin Dihydrate
CAS:Quercetin Dihydrate (Sophoretin) is a flavonoid natural product that activates or inhibits the activity of many proteins. It activates SIRT1 and inhibits PI3K.Fórmula:C15H10O7·2H2OPureza:97.77% - 99.79%Forma y color:Yellow SolidPeso molecular:338.2725(R,S)-Ruscogenin
CAS:25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.Fórmula:C27H42O4Pureza:99.32% - 99.40%Forma y color:SolidPeso molecular:430.62Buparlisib
CAS:Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).Fórmula:C18H21F3N6O2Pureza:95.32% - 98.45%Forma y color:SolidPeso molecular:410.39Ref: TM-T1827
5mg59,00€10mg80,00€25mg88,00€50mg109,00€100mg137,00€200mg222,00€500mg403,00€1mL*10mM (DMSO)65,00€Quercetin
CAS:Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.Fórmula:C15H10O7Pureza:96.29% - 98.13%Forma y color:Sensitive To Exposure To Air And Light Insoluble In Water Alcoholic Solutions Taste Very Bitter (Ntp 1992)Peso molecular:302.24MOMIPP
CAS:MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.Fórmula:C18H16N2O2Pureza:99.66%Forma y color:SolidPeso molecular:292.33Ref: TM-T33467
1mg108,00€5mg152,00€10mg236,00€25mg432,00€50mg595,00€100mg893,00€1mL*10mM (DMSO)233,00€(+)-Nortrachelogenin
CAS:(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.Fórmula:C20H22O7Pureza:99.88%Forma y color:SolidPeso molecular:374.38Alpelisib hydrochloride
CAS:Alpelisib hydrochloride (BYL-719 HCl) is a potent PI3Kα inhibitor (IC₅₀ = 5 nM) with selectivity and oral bioavailability. Cancer research.Fórmula:C19H23ClF3N5O2SPureza:97.64%Forma y color:SolidPeso molecular:477.93
